Biochemical and Biophysical Research Communications
Volume 227, Issue 1, 3 October 1996, Pages 200-204
Regular ArticleDopamine D2 Receptor Dimers and Receptor-Blocking Peptides
References (0)
Cited by (248)
The World of GPCR dimers – Mapping dopamine receptor D<inf>2</inf> homodimers in different activation states and configuration arrangements
2023, Computational and Structural Biotechnology JournalReceptor density influences ligand-induced dopamine D<inf>2L</inf> receptor homodimerization
2021, European Journal of PharmacologyDesign of bivalent ligands targeting putative GPCR dimers
2021, Drug Discovery TodayDecreased number of striatal cholinergic interneurons and motor deficits in dopamine receptor 2-expressing-cell-specific Dyt1 conditional knockout mice
2020, Neurobiology of DiseaseCitation Excerpt :Moreover, Dyt1 d2KO mice showed a trend of reduction of the D2R band migrated at ~59.1 kDa [D2R/β-tubulin; CT (n = 6): 100 ± 7.8%; Dyt1 d2KO (n = 8): 82.5 ± 4.9%; p = 0.077; Fig. 2B]. The striatal D2Rs migrated at ~105 and 96.1 KDa correspond to the manure form of D2R dimers, whereas the D2Rs migrated at ~59.1 KDa correspond to D2R monomers (Ng et al., 1996; Zawarynski et al., 1998). The results suggest that a loss of torsinA in the D2-expressing cells causes the reductions of D2Rs, especially the mature form of D2R dimers.
Membrane receptor activation mechanisms and transmembrane peptide tools to elucidate them
2020, Journal of Biological Chemistry
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