Regular Articlep130Cas, an Assembling Molecule of Actin Filaments, Promotes Cell Movement, Cell Migration, and Cell Spreading in Fibroblasts
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2022, Pharmacology and TherapeuticsQuantitative assessment of glioblastoma phenotypes in vitro establishes cell migration as a robust readout of Crk and CrkL activity
2021, Journal of Biological ChemistryCitation Excerpt :Although it is unclear how the change in cell culture influenced this difference, cell adhesion and spreading after re-plating under the Crk and CrkL knockdown condition may have rendered the phospho-p130Cas level more vulnerable. p130Cas is known to be phosphorylated upon fibroblast adhesion (54), and cell spreading was delayed in the absence of p130Cas (55). In contrast, cells adhered and spread before complete suppression of CRK/CRKL gene expression in the previous experiment.
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