Regular ArticleMT1-MMP Initiates Activation of pro-MMP-2 and Integrin αvβ3 Promotes Maturation of MMP-2 in Breast Carcinoma Cells
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Inhibition of β1 integrin induces its association with MT1-MMP and decreases MT1-MMP internalization and cellular invasiveness
2021, Cellular SignallingCitation Excerpt :Consistent with these observations, microscopic analyses revealed increased levels of both β1 integrin and MT1-MMP on the cell surface of non-permeabilized, β1-integrin-inhibited cells, at both 3 h and 16 h timepoints (Fig. 3E). It is well recognized that clustering of integrin receptors plays a role in modulating downstream signaling events, and that integrin clustering occurs at invadopodia [9,30,43]. Previous studies have also revealed that clustering of β1 integrin receptors with MT1-MMP functions to stabilize their interaction and leads to a subsequent increase in their surface expression [11].
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