Journal of Molecular Biology
Regular articleWeak and Strong States of Kinesin and ncd
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Backstepping Mechanism of Kinesin-1
2020, Biophysical JournalCitation Excerpt :Our new model (Fig. 6) is conventional in that ATP binding directly or indirectly gates forward stepping, with gating involving a combination of ATP-dependent unparking of the leading (tethered) head (4,5,35,36) and ATP-dependent stabilization of neck linker docking on the MT-attached trail head (37–40). Assigning K⋅ADP as the weakest binding state in the cycle is also conventional (27,28), and our assignment of the K⋅ADP-K⋅ADP state as the detaching state is also consistent with earlier models (10,15,41). The idea that some backward events are slips is also not novel; 16-, 24-nm, and larger backward displacements have previously been assigned as slips on the basis that they are too fast to represent a sequence of 8-nm steps that are each coupled to a full cycle of ATP turnover (15).
Non-tight and tight chemomechanical couplings of biomolecular motors under hindering loads
2020, Journal of Theoretical BiologyForce dependence of unbinding rate of kinesin motor during its processive movement on microtubule
2019, Biophysical Chemistry
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