Journal of Molecular Biology
Review ArticleStructural Aspects of the p53 Protein in Relation to Gene Evolution: A Second Look
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p53 at the crossroad between mitochondrial reactive oxygen species and necroptosis
2023, Free Radical Biology and MedicineButein inhibits cancer cell growth by rescuing the wild-type thermal stability of mutant p53
2023, Biomedicine and PharmacotherapyMolecular characterization, expression, and H<inf>2</inf>O<inf>2</inf> induction of p53 and mdm2 in the ricefield eel, Monopterus albus
2021, Aquaculture ReportsCitation Excerpt :In this study, we obtained the ORF sequences of p53 and mdm2 from the gonads of M. albus and analysed their sequence features. The results showed that M. albus p53 was highly conserved between bony fish and mammals, including species such as Homo sapiens, Mesocricetus auratus and Oryzias latipes (Albor et al., 2010; Chen et al., 2001; Krause et al., 1997; Karim and Ali, 2009; Soussi and May, 1996). The Mdm2 of M. albus was highly conserved in relation to the sequences of other vertebrates, including M. musculus and H. sapiens (Fahraeus and Olivaresillana, 2014; Okoro et al., 2012).
Identification and characterisation of Emp53, the homologue of human tumor suppressor p53, from Echinococcus multilocularis: Its role in apoptosis and the oxidative stress response
2015, International Journal for ParasitologyCitation Excerpt :The deduced protein sequence (692 amino acids) was then aligned with well-characterised members of the p53 family and human p63 and p73. As shown in Fig. 1A, significant similarity between Emp53 and the vertebrate p53 family is mostly limited to the regions involved in DNA binding (conserved regions II–V) (Soussi and May, 1996). Six out of eight amino acids implicated in DNA binding (Cho et al., 1994) are conserved in Emp53, and one is similar.
Cyclopenta[c]phenanthrenes - Chemistry and biological activity
2013, Chemico-Biological InteractionsRole of TP53 Arg72Pro polymorphism in urinary bladder cancer predisposition and predictive impact of proline related genotype in advanced tumors in an ethnic Kashmiri population
2010, Cancer Genetics and CytogeneticsCitation Excerpt :TP53, a representative tumor suppressor, gene located on chromosome 17p13, is one of the most commonly mutated genes in all types of human cancer [5,6]. It is responsible for the transcription of a site-specific DNA-binding protein and acts as a transcription factor of cell growth–regulator genes [7]. It has been revealed that TP53 somatic mutations are found primarily in high-grade and invasive bladder tumors, contributing about 35–72% of muscle-invasive bladder tumors [8,9].
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