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Polyomaviruses and Human Diseases pp 85–95Cite as

Molecular Genetics of the BK Virus

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 577))

Abstract

The BK Virus (BKV) genome is a double-stranded, circular DNA molecule with genetic organization similar to other polyomaviruses, and high homology to JC Virus (JCV) and SV40. The archetypal form of BKV noncoding regulatory region (NCRR) is the infectious form of BKV that replicates in the urothelium and is excreted in the urine. Rearranged forms of the NCRR are found in kidney and other tissues often in association with disease. BKV strains can be assigned to genotype/serotype groups based on sequence variation in the VP1 gene. Sequencing of the complete genomes from patient samples will enhance BKV phylogenetic studies and identify genotypic differences and naturally occurring mutations in BKV that may correlate with incidence and/or severity of a disease. This chapter is a review of the molecular genetics of the BK virus in respect to BKV disease.

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References

  1. Gardner SD, Field AM, Coleman DV et al. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet 1971; i:1253–1257.

    Article  Google Scholar 

  2. Hashida Y, Gaffney PC, Yunis EJ. Acute hemorrhagic cystitis of childhood and papova-like particles. J Pediatr 1976; 89:85–87.

    Article  PubMed  CAS  Google Scholar 

  3. Chatterjee M, Weyandt TB, Frisque RJ. Identification of archetype and rearranged forms of BK virus in leukocytes from healthy individuals. J Med Virol 2000; 60:353–362.

    Article  PubMed  CAS  Google Scholar 

  4. Yang RC, Wu R. BK virus DNA: Complete nucleotide sequence of a human tumor virus. Science 1979; 206:456–462.

    Article  PubMed  CAS  Google Scholar 

  5. Greenlee JE, Becker LE, Narayan O et al. Failure to demonstrate papovavirus tumor antigen in human cerebral neoplasms. Ann Neurol 1978; 3:479–481.

    Article  PubMed  CAS  Google Scholar 

  6. Monaco MCG, Jensen PN, Hou J et al. Detection of JC virus DNA in human tonsil tissue: Evidence for site of initial viral infection. J Virol 1998; 72:9918–9923.

    PubMed  CAS  Google Scholar 

  7. Goudsmit J, Wertheim-van Dillen P, Van Strien A et al. The role of BK virus in acute respiratory tract disease and the presence of BKV DNA in tonsils. J Med Virol 1982; 10:91–99.

    Article  PubMed  CAS  Google Scholar 

  8. Bendiksen S, Rekvig OP, Van Ghelue M et al. VP1 DNA sequences of JC and BK viruses detected in urine of systemic lupus erythematosus patients reveal no differences from strains expressed in normal individuals. J Gen Virol 2000; 81:2625–2633.

    PubMed  CAS  Google Scholar 

  9. Coleman DV, Wolfendale MR, Daniel RA et al. A prospective study of human polyomavirus infection in pregnancy. J Infect Dis 1980; 142:1–8.

    PubMed  CAS  Google Scholar 

  10. Drachenberg CB, Papadimitriou JC, Wali R et al. BK polyoma virus allograft nephropathy: Ultra-structural features from viral cell entry to lysis. Am J Transplant 2003; 3:1383–1392.

    Article  PubMed  Google Scholar 

  11. Keppler OT, Stehling P, Herrmann M et al. Biosynthetic modulation of sialic acid-dependent virus-receptor interactions of two primate polyoma viruses. J Biol Chem 1995; 270:1308–1314.

    Article  PubMed  CAS  Google Scholar 

  12. Norkin LC, Anderson HA, Wolfrom SA et al. Caveolar endocytosis of simian virus 40 is followed by brefeldin A-sensitive transport to the endoplasmic reticulum, where the virus disassembles. J Virol 2002; 76:5156–5166.

    Article  PubMed  CAS  Google Scholar 

  13. Beth E, Giraldo G, Schmidt-Ullrich R et al. BK virus-transformed inbred hamster brain cells. I. Status of the viral DNA and the association of BK virus early antigens with purified plasma membranes. J Virol 1981; 40:276–284.

    PubMed  CAS  Google Scholar 

  14. Chenciner N, Meneguzzi G, Corallini A et al. Integrated and free viral DNA in hamster tumors induced by BK virus. Proc Natl Acad Sci USA 1980; 77:975–979.

    Article  PubMed  CAS  Google Scholar 

  15. Meneguzzi G, Chenciner N, Corallini A et al. The arrangement of integrated viral DNA is different in BK virus-transformed mouse and hamster cells. Virology 1981; 111:139–153.

    Article  PubMed  CAS  Google Scholar 

  16. Moens U, Rekvig OP. Molecular biology of BK virus and clinical and basic aspects of BK virus renal infection. In: Khalili K, Stoner GL, eds. Human Polyomaviruses: Molecular and Clinical Perspectives 2001:359–408.

    Google Scholar 

  17. Deyerle KL, Subramani S. Human papovavirus BK early gene regulation in nonpermissive cells. Virology 1989; 169:385–396.

    Article  PubMed  CAS  Google Scholar 

  18. Corallini A, Tognon M, Negrini M et al. Evidence for BK virus as a human tumor virus. In: Khalili K, Stoner GL, eds. Human Polyomaviruses: Molecular and Clinical Perspectives 2001:431–60.

    Google Scholar 

  19. Harris KF, Christensen JB, Imperiale MJ. BK virus large T antigen: Interactions with the retinoblastoma family of tumor suppressor proteins and on cellular growth control. J Virol 1996; 70:2378–2386.

    PubMed  CAS  Google Scholar 

  20. Shivakumar CV, Das GC. Interaction of human polyomavirus BK with the tumor-suppressor protein p53. Oncogene 1996; 13:323–332.

    PubMed  CAS  Google Scholar 

  21. Dyson N, Bernards R, Friend SH et al. Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol 1990; 64:1353–1356.

    PubMed  CAS  Google Scholar 

  22. Kang S, Folk WR. Lymphotropic papovavirus transforms hamster cells without altering the amount or stability of p53. Virology 1992; 191:754–764.

    Article  PubMed  CAS  Google Scholar 

  23. Beckmann AM, Shah KV. Propagation and primary isolation of JCV and BKV in urinary epithelial cell cultures. Prog Clin Biol Res 1983; 105:3–14.

    PubMed  CAS  Google Scholar 

  24. Takemoto KK, Mullarkey MF. Human papovavirus, BK strain: Biological studies including antigenic relationship to simian virus 40. J Virol 1973; 12:625–631.

    PubMed  CAS  Google Scholar 

  25. Marshall WF, Telenti A, Proper J et al. Rapid detection of polyomavirus BK by a shell vial cell culture assay. J Clin Microbiol 1990; 28:1613–1615.

    PubMed  CAS  Google Scholar 

  26. Seehafer J, Carpenter P, Downer DN et al. Observations on the growth and plaque assay of BK virus in cultured human and monkey cells. J Gen Virol 1978; 38:383–387.

    Article  PubMed  CAS  Google Scholar 

  27. Seif I, Khoury G, Dhar R. The genome of human papovavirus BKV. Cell 1979; 18:963–977.

    Article  PubMed  CAS  Google Scholar 

  28. Rubinstein R, Harley EH. BK virus DNA cloned directly from human urine confirms an archetypal structure for the transcriptional control region. Virus Genes 1988; 2:157–165.

    Article  Google Scholar 

  29. Sundsfjord A, Johansen T, Flaegstad T et al. At least two types of control regions can be found among naturally occurring BK virus strains. J Virol 1990; 64:3864–3871.

    PubMed  CAS  Google Scholar 

  30. Flaegstad T, Sundsfjord A, Arthur RR et al. Amplification and sequencing of the control regions of BK and JC virus from human urine by polymerase chain reaction. Virology 1991; 180:553–560.

    Article  PubMed  CAS  Google Scholar 

  31. Markowitz RB, Eaton BA, Kubik MF et al. BK virus and JC virus shed during pregnancy have predominantly archetypal regulatory regions. J Virol 1991; 65:4515–4519.

    PubMed  CAS  Google Scholar 

  32. Rubinstein R, Pare N, Harley EH. Structure and function of the transcriptional control region of nonpassaged BK virus. J Virol 1987; 61:1747–1750.

    PubMed  CAS  Google Scholar 

  33. Sundsfjord A, Flaegstad T, Flo R et al. BK and JC viruses in human immunodeficiency virus type 1-infected persons: Prevalence, excretion, viremia, and viral regulatory region. J Infect Dis 1994; 169:485–490.

    PubMed  CAS  Google Scholar 

  34. Markowitz RB, Dynan WS. Binding of cellular proteins to the regulatory region of BK virus DNA. J Virol 1988; 62:3388–3398.

    PubMed  CAS  Google Scholar 

  35. Moens U, Subramaniam N, Johansen B et al. A steroid hormone response unit in the late leader of the noncoding control region of the human polyomavirus BK confers enhanced host cell permissivity. J Virol 1994; 68:2398–2408.

    PubMed  CAS  Google Scholar 

  36. Yoshiike K, Takemoto KK. Studies with BK virus and monkey lymphotropic papovavirus. In: Salzman NP, ed. The Papovaviridae, The Polyomaviruses. New York: Plenum Press, 1986; 1:295–326.

    Google Scholar 

  37. Kraus RJ, Shadley L, Mertz JE. Nuclear factor 1 family members mediate repression of the BK virus late promoter. Virology 2001; 287:89–104.

    Article  PubMed  CAS  Google Scholar 

  38. Boldorini R, Omodeo-Zorini E, Suno A et al. Molecular characterization and sequence analysis of polyomavirus strains isolated from needle biopsy specimens of kidney allograft recipients. Am J Clin Pathol 2001; 116:489–494.

    Article  PubMed  CAS  Google Scholar 

  39. Stoner GL, Alappan R, Jobes DV et al. BK virus regulatory region rearrangements in brain and cerebrospinal fluid from a leukemia patient with tubulointerstitial nephritis and meningoencephali-tis. Am J Kidney Dis 2002; 39:1102–1112.

    Article  PubMed  CAS  Google Scholar 

  40. Knowles WA. The epidemiology of BK virus and the occurrence of antigenic and genomic subtypes. In: Khalili K, Stoner GL, eds. Human Polyomaviruses: Molecular and Clinical Perspectives. New York: Wiley-Liss, 2001:527–59.

    Google Scholar 

  41. Jin L. Molecular methods for identification and genotyping of BK virus. Methods Mol Biol 2001; 165:33–48.

    PubMed  CAS  Google Scholar 

  42. Agostini HT, Jobes DV, Stoner GL. Molecular evolution and epidemiology of JC virus. In: Khalili K, Stoner GL, eds. Human Polyomaviruses: Molecular and Clinical Perspectives. New York: Wiley-Liss, 2001:491–526.

    Google Scholar 

  43. Tavis JE, Walker DL, Gardner SD et al. Nucleotide sequence of the human polyomavirus AS virus, an antigenic variant of BK virus. J Virol 1989; 63:901–911.

    PubMed  CAS  Google Scholar 

  44. Jin L, Gibson PE, Knowles WA et al. BK virus antigenic variants: Sequence analysis within the capsid VP1 epitope. J Med Virol 1993; 39:50–56.

    Article  PubMed  CAS  Google Scholar 

  45. Baksh FK, Finkelstein SD, Swalsky PA et al. Molecular genotyping of BK and JC viruses in human polyomavirus-associated interstitial nephritis after renal transplantation. Am J Kidney Dis 2001; 38:354–365.

    Article  PubMed  CAS  Google Scholar 

  46. Bauer PH, Bronson RT, Fung SC et al. Genetic and structural analysis of a virulence determinant in polyomavirus VP1. J Virol 1995; 69:7925–7931.

    PubMed  CAS  Google Scholar 

  47. Koralnik IJ, Du Pasquier RA, Kuroda MJ et al. Association of prolonged survival in HLA-A2+ progressive multifocal leukoencephalopathy patients with a CTL response specific for a commonly recognized JC virus epitope. J Immunol 2002; 168:499–504.

    PubMed  CAS  Google Scholar 

  48. Agostini HT, Ryschkewitsch CF, Singer EJ et al. JC Virus type 2B is found more frequently in brain tissue of progressive mulitifocal leukoencephalopathy patients than in urine from controls. J Hum Virol 1998; 1:200–206.

    PubMed  CAS  Google Scholar 

  49. Smith RD, Galla JH, Skahan K et al. Tubulointerstitial nephritis due to a mutant polyomavirus BK strain, BKV (Cin), causing end-stage renal disease. J Clin Microbiol 1998; 36:1660–1665.

    PubMed  CAS  Google Scholar 

  50. Simmons DT, Loeber G, Tegtmeyer P. Four major sequence elements of simian virus 40 large T antigen coordinate its specific and nonspecific DNA binding. J Virol 1990; 64:1973–1983.

    PubMed  CAS  Google Scholar 

  51. Yogo Y, Kitamura T, Sugimoto C et al. Isolation of a possible archetypal JC virus DNA sequence from nonimmunocompromised individuals. J Virol 1990; 64:3139–3143.

    PubMed  CAS  Google Scholar 

  52. Agostini HT, Ryschkewitsch CF, Singer EJ et al. JC virus regulatory region rearrangements and genotypes in progressive multifocal leukoencephalopathy: Two independent aspects of virus variation. J Gen Virol 1997; 78:659–664.

    PubMed  CAS  Google Scholar 

  53. Ault GS, Stoner GL. Human polyomavirus JC promoter/enhancer rearrangement patterns from progressive multifocal leukoencephalopathy brain are unique derivatives of a single archetypal structure. J Gen Virol 1993; 74:1499–1507.

    Article  PubMed  CAS  Google Scholar 

  54. Pfister LA, Letvin NL, Koralnik IJ. JC virus regulatory region tandem repeats in plasma and central nervous system isolates correlate with poor clinical outcome in patients with progressive multifocal leukoencephalopathy. J Virol 2001; 75:5672–5676.

    Article  PubMed  CAS  Google Scholar 

  55. Vaz B, Cinque P, Pickhardt M et al. Analysis of the transcriptional control region in progressive multifocal leukoencephalopathy. J Neurovirol 2000; 6:398–409.

    Article  PubMed  CAS  Google Scholar 

  56. Yogo Y, Guo J, Iida T et al. Occurrence of multiple JC virus variants with distinctive regulatory sequences in the brain of a single patient with progressive multifocal leukoencephalopathy. Virus Genes 1994; 8:99–105.

    Article  PubMed  CAS  Google Scholar 

  57. Iida T, Kitamura T, Guo J et al. Origin of JC polyomavirus variants associated with progressive multifocal leukoencephalopathy. Proc Natl Acad Sci USA 1993; 90:5062–5065.

    Article  PubMed  CAS  Google Scholar 

  58. Yogo Y, Sugimoto C. The archetype concept and regulatory region rearrangement. In: Khalili K, Stoner GL, eds. Human Polyomaviruses: Molecular and Clinical Perspectives 2001:89–119.

    Google Scholar 

  59. Padgett BL, Walker DL, ZuRhein GM et al. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet 1971; 1:1257–1260.

    Article  PubMed  CAS  Google Scholar 

  60. Frisque RJ, Bream GL, Cannella MT. Human polyomavirus JC virus genome. J Virol 1984; 51:458–469.

    PubMed  CAS  Google Scholar 

  61. Stoner GL, Hübner R. The human polyomaviruses: Past, present, and future. In: Khalili K, Stoner GL, eds. Human Polyomaviruses: Molecular and Clinical Perspectives. New York: Wiley-Liss, 2001:611–63.

    Google Scholar 

  62. Knowles WA. Serendipity — the fortuitous discovery of BK virus. In: Khalili K, Stoner GL, eds. Human Polyomaviruses: Molecular and Clinical Perspectives. New York: Wiley-Liss, 2001:45–71.

    Google Scholar 

  63. Randhawa P, Baksh F, Aoki N et al. JC virus infection in allograft kidneys-Analysis by polymerase chain reaction and immunohistochemistry. Transplantation 2001; 71:1300–1303.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Translational Research Laboratory, H. Lee Moffitt Cancer and Research Institute, Tampa, Florida, USA

    Christopher L. Cubitt Ph.D.

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  1. Christopher L. Cubitt Ph.D.
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Editors and Affiliations

  1. Mayo Clinic Transplant Center, Mayo Clinic - College of Medicine, Jacksonville, Florida, USA

    Nasimul Ahsan M.D., FACP

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Cubitt, C.L. (2006). Molecular Genetics of the BK Virus. In: Ahsan, N. (eds) Polyomaviruses and Human Diseases. Advances in Experimental Medicine and Biology, vol 577. Springer, New York, NY. https://doi.org/10.1007/0-387-32957-9_6

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