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From Cytoskeleton to Gene Expression: Actin in the Nucleus

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Book cover The Actin Cytoskeleton

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 235))

Abstract

Although most people still associate actin mainly with the cytoskeleton, several lines of evidence, with the earliest studies dating back to decades ago, have emphasized the importance of actin also inside the cell nucleus. Actin has been linked to many gene expression processes from gene activation to chromatin remodeling, but also to maintenance of genomic integrity and intranuclear movement of chromosomes and chromosomal loci. Recent advances in visualizing different forms and dynamic properties of nuclear actin have clearly advanced our understanding of the basic concepts by which actin operates in the nucleus. In this chapter we address the different breakthroughs in nuclear actin studies, as well as discuss the regulation nuclear actin and the importance of nuclear actin dynamics in relation to its different nuclear functions. Our aim is to highlight the fact that actin should be considered as an essential component of the cell nucleus, and its nuclear actions should be taken into account also in experiments on cytoplasmic actin networks.

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  1. Program in Cell and Molecular Biology, Institute of Biotechnology, University of Helsinki, 56, Helsinki, Finland

    Tiina Viita & Maria K. Vartiainen

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  1. Cell Biology, Life Sciences, BRICS, TU Braunschweig, Braunschweig, Germany

    Brigitte M. Jockusch

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Viita, T., Vartiainen, M.K. (2016). From Cytoskeleton to Gene Expression: Actin in the Nucleus. In: Jockusch, B. (eds) The Actin Cytoskeleton. Handbook of Experimental Pharmacology, vol 235. Springer, Cham. https://doi.org/10.1007/164_2016_27

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