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Building the Machines: Scaffolding Protein Functions During Bacteriophage Morphogenesis

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Viral Molecular Machines

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 726))

Abstract

For a machine to function, it must first be assembled. The morphogenesis of the simplest icosahedral virus would require only 60 copies of a single capsid protein to coalesce. If the capsid protein’s structure could be entirely dedicated to this endeavor, the morphogenetic mechanism would be relatively uncomplicated. However, capsid proteins have had to evolve other functions, such as receptor recognition, immune system evasion, and the incorporation of other structure proteins, which can detract from efficient assembly. Moreover, evolution has mandated that viruses obtain additional proteins that allow them to adapt to their hosts or to more effectively compete in their respective niches. Consequently, genomes have increased in size, which has required capsids to do likewise. This, in turn, has lead to more complex icosahedral geometries. These challenges have driven the evolution of scaffolding proteins, which mediate, catalyze, and promote proper virus assembly. The mechanisms by which these proteins perform their functions are discussed in this review.

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Authors and Affiliations

  1. Department of Microbiology, University of Alabama at Birmingham, BBRB 416/6, 845 19th St. South, Birmingham, AL, 35294-2170, USA

    Peter E. Prevelige

  2. Department of Plant Sciences, The BIO5 Institute, University of Arizona, Keating Building, 1657 E. Helen Street, Tucson, AZ, 85721, USA

    Bentley A. Fane

Authors
  1. Peter E. Prevelige
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  2. Bentley A. Fane
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Correspondence to Peter E. Prevelige .

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Editors and Affiliations

  1. Dept. Biological Sciences, Purdue University, W. State St. 915, West Lafayette, 47907-2054, Indiana, USA

    Michael G. Rossmann

  2. Dept. Biology, Catholic University of America, Washington, 20064, District of Columbia, USA

    Venigalla B. Rao

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Prevelige, P.E., Fane, B.A. (2012). Building the Machines: Scaffolding Protein Functions During Bacteriophage Morphogenesis. In: Rossmann, M., Rao, V. (eds) Viral Molecular Machines. Advances in Experimental Medicine and Biology, vol 726. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0980-9_14

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