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Hybrid Methods for B-Cell Epitope Prediction

Approaches to the Development and Utilization of Computational Tools for Practical Applications

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Immunoinformatics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1184))

Abstract

Many computational approaches to B-cell epitope prediction have been published, including combinations of previously proposed methods, which complicates the tasks of further developing such computational approaches and of selecting those most appropriate for practical applications (e.g., the design of novel immunodiagnostics and vaccines). These tasks are considered together herein to clarify their close but often overlooked interrelationship, thereby providing a guide to their performance in mutual support of one another, with emphasis on key physicochemical and biological considerations that are relevant from an applications perspective. This aims to assist investigators in performing either or both tasks, with the overall goals of successfully applying computational tools towards practical ends and of generating informative new data towards iterative improvement of the tools, particularly as regards the design of peptide-based immunogens for eliciting the production of antipeptide antibodies that modulate biological activity of protein targets via functionally relevant cross-reactivity in relation to the phenomena of protein folding and protein disorder.

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Acknowledgements

This work was supported by an Angelita T. Reyes Centennial Professorial Chair grant.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, Room 101, Medical Annex Building (Salcedo Hall), 547 Pedro Gil Street, Ermita, Manila, 1000, Philippines

    Salvador Eugenio C. Caoili

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  1. Salvador Eugenio C. Caoili
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Correspondence to Salvador Eugenio C. Caoili .

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  1. Indian Statistical Institute, Kolkata, West Bengal, India

    Rajat K. De

  2. Indian Statistical Institute, Kolkata, West Bengal, India

    Namrata Tomar

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Caoili, S.E.C. (2014). Hybrid Methods for B-Cell Epitope Prediction. In: De, R., Tomar, N. (eds) Immunoinformatics. Methods in Molecular Biology, vol 1184. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1115-8_14

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  • DOI: https://doi.org/10.1007/978-1-4939-1115-8_14

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