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Unconventional Protein Secretion pp 3–29Cite as

ER to Golgi-Dependent Protein Secretion: The Conventional Pathway

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1459))

Abstract

Secretion is the cellular process present in every organism that delivers soluble proteins and cargoes to the extracellular space. In eukaryotes, conventional protein secretion (CPS) is the trafficking route that secretory proteins undertake when are transported from the endoplasmic reticulum (ER) to the Golgi apparatus (GA), and subsequently to the plasma membrane (PM) via secretory vesicles or secretory granules. This book chapter recalls the fundamental steps in cell biology research contributing to the elucidation of CPS; it describes the most prominent examples of conventionally secreted proteins in eukaryotic cells and the molecular mechanisms necessary to regulate each step of this process.

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  1. Institute of Biochemistry and Biology, Plant Physiology, University of Potsdam, Karl-Liebknecht-Str. 24-25, Building 20, 14476, Potsdam, Germany

    Corrado Viotti

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  1. Instituto di Bioscienze e Biorisorse, Perugia, Italy

    Andrea Pompa

  2. Instituto di Bioscienze e Biorisorse, Perugia, Italy

    Francesca De Marchis

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Viotti, C. (2016). ER to Golgi-Dependent Protein Secretion: The Conventional Pathway. In: Pompa, A., De Marchis, F. (eds) Unconventional Protein Secretion. Methods in Molecular Biology, vol 1459. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3804-9_1

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