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Sigma Receptors: Their Role in Disease and as Therapeutic Targets pp 201–211Cite as

Stimulation of the Sigma-1 Receptor and the Effects on Neurogenesis and Depressive Behaviors in Mice

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 964))

Abstract

Sigma-1 receptor (Sig-1R) is molecular chaperone regulating calcium efflux from the neuronal endoplasmic reticulum to mitochondria. Recent studies show that Sig-1R stimulation antagonizes depressive-like behaviors in animal models, but molecular mechanisms underlying this effect remain unclear. Here, we focus on the effects of Sig-1R ligands on hippocampal neurogenesis and depressive-like behaviors. Sig-1R stimulation also enhances CaMKII /CaMKIV and protein kinase B (Akt) activities in hippocampus. Therefore, we discuss the fundamental roles of Sig-1R, CaMKII /CaMKIV and protein kinase B (Akt) signaling in amelioration of depressive-like behaviors following Sig-1R stimulation.

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Abbreviations

Akt:

protein kinase B

BDNF :

brain-derived neurotrophic factor

BrdU:

bromodeoxyuridine

CaMKII :

calcium/calmodulin-dependent protein kinase II

CaMKIV :

calcium/calmodulin-dependent protein kinase IV

CREB:

cAMP-responsive element binding protein

DG:

dentate gyrus

DHEA:

dehydroepiandrosterone

ER/SR:

endoplasmic/sacroplasmic reticulum

ERK:

extracellular signal-regulated kinase

LTP:

long-term potentiation

NMDAR:

N-methyl-D-aspartate receptor

SERCA:

sarcoplasmic/endoplasmic Ca2+-ATPase

Sig-1R:

sigma-1 receptor

SSRIs:

selective serotonin reuptake inhibitors

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Authors and Affiliations

  1. Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan

    Kohji Fukunaga & Shigeki Moriguchi

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  1. Kohji Fukunaga
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  2. Shigeki Moriguchi
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Correspondence to Kohji Fukunaga .

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Editors and Affiliations

  1. Departments of Cellular Biology and Anatomy and Ophthalmology and the James and Jean Culver Vision Discovery Institute, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

    Sylvia B. Smith

  2. Cellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland, USA

    Tsung-Ping Su

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Fukunaga, K., Moriguchi, S. (2017). Stimulation of the Sigma-1 Receptor and the Effects on Neurogenesis and Depressive Behaviors in Mice. In: Smith, S., Su, TP. (eds) Sigma Receptors: Their Role in Disease and as Therapeutic Targets. Advances in Experimental Medicine and Biology, vol 964. Springer, Cham. https://doi.org/10.1007/978-3-319-50174-1_14

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