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Retromer and Its Role in Regulating Signaling at Endosomes

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Endocytosis and Signaling

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 57))

Abstract

The retromer complex is a key element of the endosomal protein sorting machinery being involved in trafficking of proteins from endosomes to the Golgi and also endosomes to the cell surface. There is now accumulating evidence that retromer also has a prominent role in regulating the activity of many diverse signaling proteins that traffic through endosomes and this activity has profound implications for the functioning of many different cell and tissue types from neuronal cells to cells of the immune system to specialized polarized epithelial cells of the retina. In this review, the protein composition of the retromer complex will be described along with many of the accessory factors that facilitate retromer-mediated endosomal protein sorting to detail how retromer activity contributes to the regulation of several distinct signaling pathways.

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Acknowledgements

I would like to thank Aamir Mukadam for critical reading of the manuscript. MNJS is funded by the Medical Research Council.

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Authors and Affiliations

  1. Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrookes Hospital, Cambridge, CB2 0XY, UK

    Matthew N. J. Seaman

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Correspondence to Matthew N. J. Seaman .

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Editors and Affiliations

  1. Membrane Dynamics and Mechanics of Intracellular Signaling Laboratory, CNRS UMR3666, INSERM U1143, Institut Curie—Centre de Recherche, PSL Research University, Paris, France

    Christophe Lamaze

  2. Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

    Ian Prior

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Seaman, M.N.J. (2018). Retromer and Its Role in Regulating Signaling at Endosomes. In: Lamaze, C., Prior, I. (eds) Endocytosis and Signaling. Progress in Molecular and Subcellular Biology, vol 57. Springer, Cham. https://doi.org/10.1007/978-3-319-96704-2_5

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