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Regulation of KSHV Lytic Gene Expression

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Kaposi Sarcoma Herpesvirus: New Perspectives

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 312))

Abstract

The life cycle of KSHV, latency versus lytic replication, is mainly determined at the transcriptional regulation level. A viral immediate-early gene product, replication and transcription activator (RTA), has been identified as the molecular switch for initiation of the lytic gene expression program from latency. Here we review progress on two key questions: how RTA gene expression is controlled by viral proteins and cellular signals and how RTA regulates the expression of downstream viral genes. We summarize the interactions of RTA with cellular and other viral proteins. We also discuss critical issues that must be addressed in the near future.

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Authors and Affiliations

  1. Center for Infection and Immunity, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, P.R. China

    H. Deng

  2. School of Dentistry, University of California at Los Angeles, Los Angeles, CA, 90095, USA

    H. Deng

  3. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, 30322, USA

    Y. Liang

  4. Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA, 90095, USA

    R. Sun

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  1. H. Deng
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  2. Y. Liang
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  3. R. Sun
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Editor information

Editors and Affiliations

  1. Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK

    Chris Boshoff MRCP, Ph.D.

  2. Wohl Virion Centre, Division of Infection and Immunity, University College London, 46 Cleveland Street, London, W1T 4JF, UK

    Robin A. Weiss Ph.D.

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Deng, H., Liang, Y., Sun, R. (2007). Regulation of KSHV Lytic Gene Expression. In: Boshoff, C., Weiss, R.A. (eds) Kaposi Sarcoma Herpesvirus: New Perspectives. Current Topics in Microbiology and Immunology, vol 312. Springer, Berlin, Heidelberg . https://doi.org/10.1007/978-3-540-34344-8_6

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