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Centromere pp 33–52Cite as

The Centromere-Drive Hypothesis: A Simple Basis for Centromere Complexity

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Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 48))

Abstract

Centromeres are far more complex and evolutionarily labile than expected based on their conserved, essential function. The rapid evolution of both centromeric DNA and proteins strongly argue that centromeres are locked in an evolutionary conflict to increase their odds of transmission during asymmetric (female) meiosis. Evolutionary success for “cheating” centromeres can result in highly deleterious consequences for the species, either in terms of skewed sex ratios or male sterility. Centromeric proteins evolve rapidly to suppress the deleterious effects of “centromere-drive.” This chapter summarizes the mounting evidence in favor of the centromere-drive model, and its implications for centromere evolution in taxa with variations in meiosis.

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Acknowledgements

The author’s lab is supported for its studies on centromeres by a grant from the National Institutes of Health (R01-GM74108). The author is grateful to Josh Bayes and Danielle Vermaak for their comments and help with figures.

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  1. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA, 98109

    Harmit S. Malik

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    Malik, H.S. (2009). The Centromere-Drive Hypothesis: A Simple Basis for Centromere Complexity. In: Ugarkovic, D. (eds) Centromere. Progress in Molecular and Subcellular Biology, vol 48. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00182-6_2

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