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VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016 pp 698–701Cite as

Computer models for ions under electric and magnetic fields: random walks and relocation of calcium in dendrites depends on timing and population type

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Part of the book series: IFMBE Proceedings ((IFMBE,volume 60))

Abstract

In this computational study we analyze segregated population of ions in biological tissues and how electric or magnetic fields can relocate them. The appropriate definition of a segregated population of ions is justified for its physiological relevance, algorithmic simplicity and biophysical realism. Although this study can be valid for several ions and cell compartments, we focus on calcium ions in parallel dendrites of neurons. Computer simulations are presented as calcium flux visualizations showing the final position of each ion in different conditions in neurons: in the absence of an electric field and in the presence of it at different timings in relation to the initial release event of calcium into the dendrites. The simulation suggests that it is possible to relocate (probabilistically) aggregations of calcium ions in the spaces of the dendrites, allowing neuromodulation of synaptic connections. In conclusion, the maximal response to endogenous electric fields and the efficient way to design “friendly” devices for electrical field stimulation of neurons for relocating calcium ions close to their targets (e.g. vesicle sensors, proteins in membranes, or cytosol) depends on the geometry of dendrites, the duration and timing of the field (respect to ongoing activity), and the selection of the appropriate subpopulation we want to relocate.

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Authors and Affiliations

  1. International Group of Neuroscience, IGN (Colombia, USA, Europe, India), Cra 64c #48-94 (603), Medellin, Colombia

    J. F. Gomez-Molina

  2. Genetics and Biochemistry of Microorganisms group (GEBIOMIC), Biology Institute, FCEN, University of Antioquia, calle 67 no. 53 – 108, block 7, office: 318, Medellín, Colombia

    M. Corredor

  3. Informática y Sistemas, EAFIT University, Carrera 49 N° 7 Sur-50, Medellín, Colombia

    A. A. Restrepo-Velasquez

  4. Department of Biology, Chemistry and Environmental Science, Northern New Mexico College, 921 N. Paseo de Oñate Española, Española, NM, NM 87532, USA

    U. M. Ricoy

Authors
  1. J. F. Gomez-Molina
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  2. M. Corredor
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  3. A. A. Restrepo-Velasquez
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  4. U. M. Ricoy
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Corresponding author

Correspondence to J. F. Gomez-Molina .

Editor information

Editors and Affiliations

  1. Asociación Colombiana de Bioingeniería y Electrónica Médica - ABIOIN, Bucamaranga, Colombia

    Isnardo Torres

  2. Universidad Pontificia Bolivariana - UPB, Centro de Bioingeniería, Medellín, Colombia

    John Bustamante

  3. Universidad Industrial de Santander, Escuela de Ing. Eléctrica, Electrónica, Bucaramanga, Colombia

    Daniel A. Sierra

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Gomez-Molina, J.F., Corredor, M., Restrepo-Velasquez, A.A., Ricoy, U.M. (2017). Computer models for ions under electric and magnetic fields: random walks and relocation of calcium in dendrites depends on timing and population type. In: Torres, I., Bustamante, J., Sierra, D. (eds) VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016. IFMBE Proceedings, vol 60. Springer, Singapore. https://doi.org/10.1007/978-981-10-4086-3_175

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  • DOI: https://doi.org/10.1007/978-981-10-4086-3_175

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-4085-6

  • Online ISBN: 978-981-10-4086-3

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