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Stress and the Etiopathogenesis of Alzheimer’s Disease and Depression

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Tau Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1184))

Abstract

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with a complex physiopathology whose initiators are poorly defined. Accumulating clinical and experimental evidence suggests a causal role of lifetime stress in AD. This chapter summarizes current knowledge about how chronic stress and its accompanying high levels of glucocorticoid (GC) secretion, trigger the two main pathomechanisms of AD: (i) misprocessing of amyloid precursor protein (APP) and the generation of amyloid beta (Aβ) and (ii) Tau hyperphosphorylation and aggregation. Given that depression is a well-known stress-related illness, and the evidence that depression may precede AD, this chapter also explores neurobiological mechanisms that may be common to depressive and AD pathologies. This review also discusses emerging insights into the role of Tau and its malfunction in disrupting neuronal cascades and neuroplasticity and, thus triggering brain pathology.

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Authors and Affiliations

  1. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho – Campus de Gualtar, Braga, Portugal

    Ioannis Sotiropoulos, Joana M. Silva, Patricia Gomes & Nuno Sousa

  2. ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal

    Ioannis Sotiropoulos, Joana M. Silva, Patricia Gomes & Nuno Sousa

  3. Max Planck Institute of Psychiatry, Munich, Germany

    Osborne F. X. Almeida

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  1. Ioannis Sotiropoulos
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  2. Joana M. Silva
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  3. Patricia Gomes
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  4. Nuno Sousa
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  5. Osborne F. X. Almeida
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Correspondence to Ioannis Sotiropoulos .

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Editors and Affiliations

  1. Department of Life Sciences, Gakushuin University, Tokyo, Japan

    Akihiko Takashima

  2. Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA

    Benjamin Wolozin

  3. University of Lille, INSERM, CHU-Lille, Alzheimer & Tauopathies, LabEx DISTALZ, Lille, France

    Luc Buee

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Sotiropoulos, I., Silva, J.M., Gomes, P., Sousa, N., Almeida, O.F.X. (2019). Stress and the Etiopathogenesis of Alzheimer’s Disease and Depression. In: Takashima, A., Wolozin, B., Buee, L. (eds) Tau Biology. Advances in Experimental Medicine and Biology, vol 1184. Springer, Singapore. https://doi.org/10.1007/978-981-32-9358-8_20

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