Abstract
The human major histocompatibility complex (MHC) region is a genomic region spanning about 4000 kilobases (kb) including the class I, class II, and class III subregion . The class I subregion is larger than the two others but with fewer genes described to date. It includes a classical human leucocyte antigen (HLA) class I genes (HLA-A, HLA-B, HLA-C) which are highly polymorphic and encode products presenting the endogenous antigenic peptides to the T-cell receptors, and b non-classical class I genes (HLA-E, HLA-F, HLA-G) whose function is still unknown. In this study, we describe the first coding sequence which is not structurally related to the class I genes, although it is localized within the MHC class I region. This novel gene, P5-1, belongs to a multiple copy family, all members of which map within the MHC. Although the P5-1 sequence showed no similarity to sequences in different databanks, its transcription, which is restricted to lymphoid tissues, argues for an immunological function of its product.
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The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession number L06 175.
Correspondence to: C. Vernet.
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Vernet, C., Ribouchon, MT., Chimini, G. et al. A novel coding sequence belonging to a new multicopy gene family mapping within the human MHC class I region. Immunogenetics 38, 47–53 (1993). https://doi.org/10.1007/BF00216390
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DOI: https://doi.org/10.1007/BF00216390