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Influence of deficiency of the histone gene-containing 38B-40 region on X-chromosome template activity and the White gene position effect variegation in Drosophila melanogaster

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Summary

The deficiency of the 38B-40 region containing histone genes in one of the 2nd chromosomes of D. melanogaster triploid intersexes increases the template activity of X-chromosomes both in vivo and in vitro without noticeably affecting autosome activity. This deficiency in the heterozygous state inhibits the variegated position effect of the white gene in the T(1;3)w vcotranslocation in diploid females and males, but not affect their rate of development. The variegation suppressor Su(var)hg-1 not only suppress the gene position effect in diploid flies, but also increases the template activity of X-chromosomes in triploid intersexes.

The results are discussed with respect to the dependence of gene activity on the structure of chromosomes (density of DNP packing).

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  1. Institute of Molecular Genetics, USSR Academy of Sciences, 123182, Moscow D-182, USSR

    R. B. Khesin & B. A. Leibovitch

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  1. R. B. Khesin
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  2. B. A. Leibovitch
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Communicated by D.M. Goldfarb

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Khesin, R.B., Leibovitch, B.A. Influence of deficiency of the histone gene-containing 38B-40 region on X-chromosome template activity and the White gene position effect variegation in Drosophila melanogaster . Molec. Gen. Genet. 162, 323–328 (1978). https://doi.org/10.1007/BF00268858

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  • DOI: https://doi.org/10.1007/BF00268858

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