Skip to main content
SpringerLink
Log in

The Drosophila Tumorous lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus

  • Original Articles
  • Published:
Molecular and General Genetics MGG Aims and scope Submit manuscript

Abstract

The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Baker BS, Smith DA (1979) The effects of mutagen-sensitive mutants of Drosophila melanogaster in non-mutagenized cells. Genetics 92:833–847

    Google Scholar 

  • Corwin HO, Hanratty WP (1976) Characterization of a unique lethal tumorous mutation in Drosophila. Mol Gen Genet 14:345–347

    Google Scholar 

  • Craymer L, Roy E (1980) New mutants. Dros Inf Serv 55:200–204

    Google Scholar 

  • Gateff EA, Mechler BM (1989) Tumor-suppressor gene of Drosophila melanogaster. CRC Crit Rev Oncogenesis 1:221–245

    Google Scholar 

  • Geer BW, Lischwe TD, Murphy KG (1983) Male fertility in Drosophila melanogaster: Genetics of the vermilion region. J Exp Zool 225:107–118

    Google Scholar 

  • Hanratty WP, Ryerse JS (1981) A genetic melanotic neoplasm of Drosophila melanogaster. Dev Biol 83:238–249

    Google Scholar 

  • Lefevre G (1971) Salivary chromosome bands and frequency of crossing-over in Drosophila melanogaster. Genetics 67:497–513

    Google Scholar 

  • Lefevre G (1981) The distribution of randomly recovered X-ray induced sex-linked genetic effects in Drosophila melanogaster. Genetics 99:461–480

    Google Scholar 

  • Lefevre G, Watkins W (1986) The question of the total gene number in Drosophila melanogaster. Genetics 113:869–895

    Google Scholar 

  • Lindsley DL, Zimm GG (1992) The genome of Drosophila melanogaster. Academic Press, San Diego

    Google Scholar 

  • Nappi AS, Kmiecik J, Silvers M (1984) Cellular immune competence of a Drosophila mutant with neoplastie hematopoietic organs. J Invert Pathol 44:220–227

    Google Scholar 

  • Nappi AJ, Silvers M (1984) Cell surface changes associated with cellular immune reactions in Drosophila. Science 225: 1166–1168

    Google Scholar 

  • Perrimon N, Mahowald AP (1986) l(l)hopscotch, a larval-pupal zygotic lethal with a specific maternal effect_ on segmentation in Drosophila. Dev Biol 118:28–41

    Google Scholar 

  • Rizki TM (1978) The circulatory system and associated cells and tissues. In: Ashburner M, Wright TRF (eds) The genetics and biology of Drosophila, Vol 2B. Academic Press, New York, pp 398–452

    Google Scholar 

  • Rosengard AM, Krutzsch HC, Shearn A, Biggs JR, Barker E, Margulies IM, King CR, Liotta LA, Steeg PS (1989) Reduced Nm23/awd protein in tumour metastasis and aberrant Drosophila development. Nature 342:177–180

    Google Scholar 

  • Shilo B-Z (1987) Proto-oncogenes in Drosophila melanogaster. Trends Genet 3:69–72

    Google Scholar 

  • Silvers M, Hanratty WP (1984) Alterations in the production of hemocytes due to a neoplastic mutation of Drosophila melanogaster. J Invert Pat. 44:324–328

    Google Scholar 

  • Sparrow JC (1978) Melanotic tumours. In: Ashburner M, Wright TRF (eds) The genetics and biology of Drosophila, Vol 2B. Academic Press, New York, pp 277–313

    Google Scholar 

  • Stewart M, Murphy C, Fristrom J (1972) The recovery and preliminary characterization of X chromosome mutants affecting imaginal discs of Drosophila melanogaster. Dev Biol 27:71–83

    Google Scholar 

  • Watson KL, Johnson TK, Denell RE (1991) Lethal(l) aberrant immune response mutations leading to melanotic tumor formation in Drosophila melanogaster. Dev Genetics 12:173–187

    Google Scholar 

  • Zhimulev IF, Semeshin VF, Belyaeva ES (1981a) Fine cytological analysis of the band 10A1-2 and the adjoining regions in the Drosophila melanogaster X chromosome. I. Cytology of the region and mapping of chromosome rearrangements. Chromosoma 82:9–23

    Google Scholar 

  • Zhimulev IF, Pokholkova GV, Bgatov AV, Semeshin VF, Belyaeve ES (1981b) Fine cytological analysis of the band 10A1-2 and the adjoining regions in the Drosophila melanogaster X chromosome. II. Genetical analysis. Chromosoma 82:25–40

    Google Scholar 

Download references

Author information

Author notes

  1. Charles R. Dearolf

    Present address: Dana Farber Cancer Institute, Room JF 209, 44 Binney Street, 02115, Boston, MA, USA

Authors and Affiliations

  1. Department of Biological Sciences, University of Southern Mississippi, 39406, Hattiesburg, MS, USA

    William P. Hanratty

  2. Department of Radiation Oncology, Harvard Medical School, Dana Farber Cancer Institute, 02115, Boston, MA, USA

    Charles R. Dearolf

Authors
  1. William P. Hanratty
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Charles R. Dearolf
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Communicated by B.H. Judd

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hanratty, W.P., Dearolf, C.R. The Drosophila Tumorous lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus. Molec. Gen. Genet. 238, 33–37 (1993). https://doi.org/10.1007/BF00279527

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00279527

Key words

Search

Navigation