Summary
Two chemists exposed to about 3 months to a mixture of dimethyl and trimethyltinchloride developed abruptly a status of mental confusion with generalized epileptic seizures. Before the acute accident they already complained of headache, episodes of violent pain sine materia in various organs and psychic disturbances (memory defects, loss of vigilance, insomnia, anorexia, disorientation). The clinical picture is rather similar to that caused by triethyltin and it is likely that the substance responsible for the patients symptomatology is trimethyltincloride. Both patients recovered completely following removal from exposure.
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References
Alajouanine, Th., Derobert, L., Thieffry, S.: Etude clinique d'ensemble de 210 cas d'intoxication par les sels organiques d'étain. Rev. Neurol. 98, 85–96 (1958)
Aldridge, W. N.: The biochemistry of organo-tin compounds. Trialkytins and oxidative phosphorylations. Biochem. J. 69, 367–376 (1958)
Barnes, J. M. Stoner, H. B.: Toxic properties of some dialkyl and trialkyl tin salts. Brit. J. Industr. Med. 15, 12–22 (1958)
Barnes, J. M., Stoner, H. B.: The toxicology of tin compounds. Pharmacol Rev. 11, 211–231 (1959)
Cahen, R., Boucard, M., Lalaurie, M., Lacour, C.: Production expérimentale d'oedème cérébral par le sulfate de triéthyl-étain. Compte-Rendu de l' Académie des Sciences, Paris 217, 1816–1819 (1970)
Cossa, P., Duplay, Fishgold, Arfel-Capdevielle, Lafon, Passouan, Minvielle, Radermecker, J.: Encéphalopathies toxiques au Stalinon. Rev. Neurol 98, 97–108 (1958)
Cremer, J. E.: The metabolism in vitro of tissue slices from rats given triethyl tin compounds. Biochem. J. 67, 87–96 (1957)
Cremer, J. E.: The biochemistry of organotin compounds: the conversion of tetraethyltin into triethyltin in mammals. Biochem. J. 68, 685–692 (1958)
Gastaut, H.: Combined photic and Metrazol activation of the brain. Electroenceph. Clin. Neurophysiol. 2, 249–261 (1950)
Gruner, J. E.: Lésions du névraxe secondaire à l'ingestion d'éthylétain (Stalinon). Rev. Neurol. 98, 109–116 (1958)
Jasper, H., Courtois, G.: A practical method for uniform activation with intravenous Metrazol. Electroenceph. Clin. Neurophysiol. 5, 443–444 (1953)
Jolyet, F., Cahours, A.: Recherches sur l'action physiologique des stanéthyles et des stanméthyles. Compte-rendu de l'Académie des Sciences, Paris 68, 1276–1280 (1869)
Lauwerys, R.: Précis de Toxicologie Industrielle et des Intoxications Professionnelles. Duculot, Belgium 1972
Lybert, G., Fast, S. L.: The use of Chlorpromazine as an activating agent. Electroenceph. Clin. Neurophysiol. 8, 711–712 (1956)
Sherwin, I., Hooge, J. P.: Comparative effectiveness of natural sleep and Methohexital. Neurology 23, 973–976 (1973)
Silverman, D.: Sleep as a general activation procedure in electroencephalography. Electroenceph. Clin. Neurophysiol. 8, 317–324 (1956)
Stewart, L. F.: Chloropromazine: use to activate electroencephalographic seizure patterns. Electroenceph. Clin. Neurophysiol. 9, 427–440 (1957)
Stoner, H. B., Barnes, J. M., Duff, J. I.: Studies on the toxicity of alkyl tin compounds. Brit. J. Pharmacol. 19, 16–25 (1955)
Ziskind, E., Sjaardema, H., Bercel, N. A.: Minimal electroencephalographic response to metrazol as a method for measuring the convulsive threshold for use in human beings. Science 104, 462–463 (1946)
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Fortemps, E., Amand, G., Bomboir, A. et al. Trimethyltin poisoning · report of two cases. Int. Arch Occup Environ Heath 41, 1–6 (1978). https://doi.org/10.1007/BF00377794
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DOI: https://doi.org/10.1007/BF00377794