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The hyperaemic response to a transient reduction in cerebral perfusion pressure

A modelling study

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Summary

A mathematical model of cerebral blood flow and the cerebrospinal fluid circulation is described which permits the study of phenomena caused by dynamic changes in cerebrovascular autoregulatory or cerebrospinal fluid compensatory reserves.

A transient decrease in cerebral perfusion pressure was produced by carotid artery compression. Comparison of the computer simulations with clinical and experimental data, reported elsewhere, suggests that the transient hyperaemic response (THR) is proportional to the strength of the autoregulatory response. The relationships between the magnitude and time course of the THR, and the period and level of reduction in CPP were studied.

This model suggests that simple clinical tests based on the examination of THR using transcranial Doppler velocity measurements are of potential value for the non-invasive assessment of the autoregulatory reserve.

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References

  1. Czosnyka M, Piechnik S, Koszewski W,et al (in press) The dynamics of cerebral blood flow, perfusion pressure and CSF circulation — a modelling study. In: Intracranial pressure VIII, Springer, Berlin Heidelberg New York

  2. Giller CA (1991) A bedside test for cerebral autoregulation using transcranial Doppler ultrasound. Acta Neurochir (Wien) 108: 7–14

    Google Scholar 

  3. Jakobsen M, Envoldsen E, Dalager T (1990): Spasm index in subarachnoid haemorrhage: consequences of vasospasm upon cerebral blood flow and oxygen extraction. Acta Neurol Scand 82(5): 311–320

    PubMed  Google Scholar 

  4. Kelley RE, Namon RA, Juang SH,et al (1990) Transcranial Doppler ultrasonography of the middle cerebral artery in the hemodynamic assessment of internal carotid artery stenosis. Arch Neurol 47(9): 960–964

    PubMed  Google Scholar 

  5. Lindegaard KF, Aaslid R, Nornes N (1986) Cerebral arteriovenous malformations. In: Aaslid R (ed) Transcranial Doppler sonography. Springer, Wien New York, pp 86–105

    Google Scholar 

  6. Nelson RJ, Perry S, Hames T, Pickard JD (1990) Transcranial Doppler ultrasound studies of cerebral autoregulation and subarachnoid haemorrhage in the rabbit. J Neurosurg 73: 601–610

    PubMed  Google Scholar 

  7. Paulson OB, Strandgaard S, Edvinsson L (1990) Cerebral autoregulation. Cerebrovascular and Brain Metabolism Reviews 2: 161–192

    PubMed  Google Scholar 

  8. Pickard JD, Matheson M, Patterson J, Wyper D (1980) Prediction of late ischaemic complication after cerebral aneurysm surgery by the intraoperative measurement of cerebral blood flow. J Neurosurg 53: 305–308

    PubMed  Google Scholar 

  9. Pickard JD, Read DH, Lovick AJH, (1985) Correlation between preoperative cerebrospinal reactivity and delayed postoperative cerebral ischaemia following aneurysmal SAH. In: Hoffmann A, Hayer S (eds) Cerebral Blood Flow and Metabolism Measurement. Springer New York, pp 149–152

    Google Scholar 

  10. Pilato MA, Bissonnette B, Lerman J (1991) Transcranial Doppler response of cerebral blood flow velocity to carbon dioxide in anaesthetized children. Can J Anaesth 38(1): 37–42

    PubMed  Google Scholar 

  11. Portnoy HD, Chopp M, Branch C,et al (1982) Cerebrospinal pulse waveform as an indicator of cerebral autoregulation. J Neurosurg 56: 666–678

    PubMed  Google Scholar 

  12. Ratnaturga C, Adiseshiah M (1990) Increase in middle cerebral artery velocity on breath holding: a simplified test of cerebral perfusion reserve. Eur J Vasc Surgery 4(5): 519–523

    Google Scholar 

  13. Romner B, Brandt L, Berntman L,et al (1991) Simultaneous transcranial Doppler sonography and cerebral blood flow measurements of cerebrovascular C02 reactivity in patients with aneurysmal subarachnoid haemorrhage. Br J Neurosurg 5: 31–37

    PubMed  Google Scholar 

  14. Seiler RW, Aaslid R (1986) Transcranial Doppler for evaluation of cerebral vasospasm. In: Aaslid R (ed) Transcranial Doppler Sonography. Springer, Wien New York pp 118–131

    Google Scholar 

  15. Seylaz G, Florence G (1991) Rapid autoregulatory changes in CBF using laser-Doppler velocimetry. J Cereb Blood Flow Metab [Suppl 2] 11: 57

    Google Scholar 

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Authors and Affiliations

  1. Warsaw University of Technology, Warsaw, Poland

    St. Piechnik

  2. Academic Neurosurgical Unit, University of Cambridge, Addenbrooke's Hospital, CB2 2QQ, Cambridge, UK

    M. Czosnyka, J. Pickard, H. Whitehouse & St. Piechnik

Authors
  1. M. Czosnyka
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  2. J. Pickard
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  3. H. Whitehouse
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  4. St. Piechnik
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Czosnyka, M., Pickard, J., Whitehouse, H. et al. The hyperaemic response to a transient reduction in cerebral perfusion pressure. Acta neurochir 115, 90–97 (1992). https://doi.org/10.1007/BF01406364

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  • DOI: https://doi.org/10.1007/BF01406364

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