Summary
Corticofugal projections were examined by means of the autoradiographic tracer method in 21 macaca fascicularis. The labeled material was injected into the main body representation areas of the precentral motor cortex and into various regions of Brodmann's areas 6, 8 and 9 of the frontal lobe. The ipsilateral subthalamic nucleus receives a moderately strong and somato-topically organized projection from Woolsey's precentral motor cortex. This projection is mainly restricted to the lateral moiety. The remaining nucleus is occupied by less intensive projections from premotor and prefrontal areas. It is concluded that the subthalamic nucleus is a convergence site of pallidal and corticomotor and frontal projections. Cortical afferents may exert an influence on the pallido-subthalamic-pallidal inhibitory feedback loop.
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References
Carpenter, M.B.: Anatomical organization of the corpus striatum and related nuclei. In: The Basal Ganglia (ed. M.D. Yahr). New York: Raven Press 1976
Carpenter, M.G., Whittier, J.R., Mettler, F.A.: Analysis of choreoid hyperkinesia in the rhesus monkey. Surgical and pharmacological analysis of hyperkinesia resulting from lesions in the subthalamic nucleus of Luys. J Comp Neurol 92, 293–332 (1950)
Carpenter, M.B., Strominger, N.L.: Efferent fibers of the subthalamic nucleus in the monkey. A comparison of the efferent projections of the subthalamic nucleus, substantia nigra and globus pallidus. Am J Anat 121, 41–72 (1967)
Carpenter, M.B., Fraser, R.A.R., Shriver, J.E.: The organization of pallidosubthalamic fibers in the monkey. Brain Res 11, 522–559 (1968)
Hartmann-von Monakow, K., Akert, K., Künzle, H.: Projections of precentral and premotor cortex to the red nucleus and other midbrain areas in macaca fascicularis. Exp Brain Res (submitted, 1978)
Jones, E.G., Coulter, J.D., Burton, H., Porter, R.: Cells of origin and terminal distribution of cortico-striatal fibers arising in the sensory-motor cortex of monkeys. J Comp Neurol 173, 53–80 (1977)
Künzle, H.: Thalamic projections from the precentral motor cortex in macaca fascicularis. Brain Res 105, 253–267 (1976)
Künzle, H.: An autoradiographic analysis of the efferent connections from premotor and adjacent prefrontal regions (areas 6 and 9) in macaca fascicularis. Brain Behav Evol (in press, 1978)
Künzle, H., Akert, K.: Efferent connections of cortical area 8 (frontal eye field) in macaca fascicularis. A reinvestigation using the autoradiographic technique. J Comp Neurol 173, 147–163 (1977)
Kuypers, H.J.M., Lawrence, D.G.: Cortical projections to the red nucleus and the brain stem in the rhesus monkey. Brain Res 4, 151–188 (1967)
Levin, P.M.: The efferent fibers of the frontal lobe of the monkey, macaca mulatta. J Comp Neurol 63, 369–419 (1936)
Levin, P.M.: Efferent fibers. In: The Precentral Motor Cortex (ed. P.C. Bucy), pp. 133–148. Urbana: University of Illinois Press 1949
Mettler, F.A.: Extracortical connections of the primate frontal cerebral cortex. II. Corticofugal connections. J Comp Neurol 86, 119–165 (1947)
Nauta, H.J.W., Cole, M.: Efferent projections of the subthalamic nucleus. Trans Am Neurol Assoc 99, 170–173 (1974)
Nauta, W.J.H., Mehler, W.R.: Projections of the lentiform nucleus in the monkey. Brain Res 1, 3–42 (1966)
Nisino, Y.: Zur Faserverbindung der lateralen Fläche der Groβhirnhemisphäre beim Affen, unter besonderer Berücksichtigung der corticalen extrapyramidalen Bahnen und der sogenannten Kleinhirnpyramide. Z Mikrosk Anat Forsch 47, 401–440 (1940)
Olszewski, J.: The thalamus in the macaca mulatta. An atlas for the use with sterotaxic instrument. pp. 1–93. Basel, New York: Karger 1952
Petras, J.M.: Some efferent connections of the motor and somatosensory cortex of simian primates and felid, canid and procyonid carnivores. Ann NY Acad Sci 167, 469–505 (1969)
Ranson, S.W., Ranson, S.W., Jr., Ranson, M.: Fiber connections of the corpus striatum as seen in Marchi preparations. AMA Arch Neurol Psychiat 46, 230–249 (1941)
Schneider, H.R.: Die Regio Subthalamica einiger Cercopitheciden. J Hirnforsch 12, 161–184 (1970)
Veazey, R.B., Severin, Ch.M.: Efferent projections of the deep mesencephalic nucleus (pars lateralis). Anat Rec 190, 572 (1978)
Verhaart, W.J.C., Kennard, M.A.: Corticofugal degeneration following thermocoagulation of areas 4, 6 and 4S in macaca mulatta. J Anat 74, 239–254 (1940)
Vogt, C., Vogt, O.: Zur Lehre der Erkrankungen des striären Systems. J Psychol Neurol (Lpz) 25, 627–846 (1920)
Whittier, J.R., Mettler, F.A.: Studies in the subthalamus of the rhesus monkey. I. Anatomy and fiber connections of the subthalamic nucleus of Luys. J Comp Neurol 90, 281–372 (1949)
Whittier, J.R., Mettler, F.A.: Studies on the subthalamus of the rhesus monkey. II. Hyperkinesia and other physiologic effects of subthalamic lesions, with special reference to the subthalamic nucleus of Luys. J Comp Neurol 90, 319–372 (1949)
Wilson, S.A.K.: An experimental research into the anatomy and physiology of the corpus striatum. Brain 36, 427–492 (1914)
Woolsey, C.N., Settlage, P.H., Meyer, D.R., Sencer, W., Hamuy, T.P., Travis, A.M.: Patterns of localization in precentral and “supplementary” motor areas and their relation to the concept of a premotor area. In: Patterns of Organization in the Central Nervous System. Res Publ Assoc Res Nerv Ment Dis 30, 238–264 (1952)
Yoshida, M., Rabin, A., Anderson, M.: Two types of monosynaptic inhibition of pallidal neurons produced by stimulation of the diencephalon and substantia nigra. Brain Res 30, 235–239 (1971)
Yoshida, M.: Functional aspects of, and the role of transmitters in, the basal ganglia. Confin Neurol 36, 282–291 (1974)
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Monakow, K.Hv., Akert, K. & Künzle, H. Projections of the precentral motor cortex and other cortical areas of the frontal lobe to the subthalamic nucleus in the monkey. Exp. Brain Res. 33, 395–403 (1978). https://doi.org/10.1007/BF00235561
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DOI: https://doi.org/10.1007/BF00235561