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Review of Ets1 structure, function, and roles in immunity

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Abstract

The Ets1 transcription factor is a member of the Ets gene family and is highly conserved throughout evolution. Ets1 is known to regulate a number of important biological processes in normal cells and in tumors. In particular, Ets1 has been associated with regulation of immune cell function and with an aggressive behavior in tumors that express it at high levels. Here we review and summarize the general features of Ets1 and describe its roles in immunity and autoimmunity, with a focus on its roles in B lymphocytes. We also review evidence that suggests that Ets1 may play a role in malignant transformation of hematopoietic malignancies including B cell malignancies.

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Acknowledgments

This work was supported by grants from the National Institutes of Health (AI085127 and AI099422) and the Alliance for Lupus Research.

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  1. Department of Biochemistry, State University of New York at Buffalo, Center of Excellence in Bioinformatics and Life Sciences, Room B3-306, 701 Ellicott Street, Buffalo, NY, 14203, USA

    Lee Ann Garrett-Sinha

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Correspondence to Lee Ann Garrett-Sinha.

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Garrett-Sinha, L.A. Review of Ets1 structure, function, and roles in immunity. Cell. Mol. Life Sci. 70, 3375–3390 (2013). https://doi.org/10.1007/s00018-012-1243-7

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  • DOI: https://doi.org/10.1007/s00018-012-1243-7

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