Abstract
The morphogenic factor sonic hedgehog (Shh) actively orchestrates many aspects of cerebellar development and maturation. During embryogenesis, Shh signaling is active in the ventricular germinal zone (VZ) and represents an essential signal for proliferation of VZ-derived progenitors. Later, Shh secreted by Purkinje cells sustains the amplification of postnatal neurogenic niches: the external granular layer and the prospective white matter, where excitatory granule cells and inhibitory interneurons are produced, respectively. Moreover, Shh signaling affects Bergmann glial differentiation and promotes cerebellar foliation during development. Here we review the most relevant functions of Shh during cerebellar ontogenesis, underlying its role in physiological and pathological conditions.
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Acknowledgments
We dedicate this work to the memory of Prof. F. Rossi for his continuous support and encouragement. This work was supported by the University of Turin and Research Fund for the Promotion of Basic Research Grant RBFR10A01S (K.L.). We thank Professor Richard Hawkes, Dr. Daniela Carulli, and Dr. Ishira Nanavaty for critical reading of this manuscript and helpful suggestions.
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Annarita De Luca and Valentina Cerrato contributed equally to this work.
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De Luca, A., Cerrato, V., Fucà, E. et al. Sonic hedgehog patterning during cerebellar development. Cell. Mol. Life Sci. 73, 291–303 (2016). https://doi.org/10.1007/s00018-015-2065-1
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DOI: https://doi.org/10.1007/s00018-015-2065-1