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Regulation of myelopoiesis by proinflammatory cytokines in infectious diseases

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Abstract

Hematopoiesis is hierarchically orchestrated by a very small population of hematopoietic stem cells (HSCs) that reside in the bone-marrow niche and are tightly regulated to maintain homeostatic blood production. HSCs are predominantly quiescent, but they enter the cell cycle in response to inflammatory signals evoked by severe systemic infection or injury. Thus, hematopoietic stem and progenitor cells (HSPCs) can be activated by pathogen recognition receptors and proinflammatory cytokines to induce emergency myelopoiesis during infection. This emergency myelopoiesis counterbalances the loss of cells and generates lineage-restricted hematopoietic progenitors, eventually replenishing mature myeloid cells to control the infection. Controlled generation of such signals effectively augments host defense, but dysregulated stimulation by these signals is harmful to HSPCs. Such hematopoietic failure often results in blood disorders including chronic inflammatory diseases and hematological malignancies. Recently, we found that interleukin (IL)-27, one of the IL-6/IL-12 family cytokines, has a unique ability to directly act on HSCs and promote their expansion and differentiation into myeloid progenitors. This process resulted in enhanced production of neutrophils by emergency myelopoiesis during the blood-stage mouse malaria infection. In this review, we summarize recent advances in the regulation of myelopoiesis by proinflammatory cytokines including type I and II interferons, IL-6, IL-27, granulocyte colony-stimulating factor, macrophage colony-stimulating factor, and IL-1 in infectious diseases.

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Abbreviations

BM:

Bone marrow

CAR:

C-X-C motif ligand 12-abundant reticular

CTL:

Cytotoxic CD8+ T cell

CXCL:

C-X-C motif ligand

DC:

Dendritic cell

EC:

Endothelial cell

G-CSF:

Granulocyte colony-stimulating factor

gp130:

β-Receptor glycoprotein 130

GM-CSF:

Granulocyte macrophage colony-stimulating factor

HSC:

Hematopoietic stem cell

HSPC:

Hematopoietic stem and progenitor cell

IFN:

Interferon

IFNAR:

IFN-α receptor

IL:

Interleukin

JAK:

Janus kinase

LCMV:

Lymphocytic choriomeningitis virus

LSK:

Lineage−Sca-1+c-Kit+

LT-HSC:

Long-term repopulating hematopoietic stem cell

M-CSF:

Macrophage colony-stimulating factor

MDSC:

Myeloid-derived suppressor cell

MPP:

Multipotent progenitor

MYD88:

Myeloid differentiation primary response gene 88

MyRP:

Myeloid-restricted progenitor cell

MSC:

Mesenchymal stem/stromal cell

NK:

Natural killer

P. :

Plasmodium

R:

Receptor

RBC:

Red blood cell

Sca-1:

Stem cell antigen-1

SCF:

Stem cell factor

STAT:

Signal transducer and activator of transcription

Th:

Helper T

TLR:

Toll-like receptor

Treg:

Regulatory T

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Acknowledgements

This study was supported in part by a Grant-in-aid and the Private University Strategic Research Based Support Project from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

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Authors and Affiliations

  1. Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan

    Yukino Chiba, Izuru Mizoguchi, Hideaki Hasegawa, Mio Ohashi, Naoko Orii, Miyaka Sugahara, Mingli Xu, Toshiyuki Owaki & Takayuki Yoshimoto

  2. Department of Immunology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan

    Taro Nagai

  3. Institute for Human Life Innovation, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo, 112-8610, Japan

    Miyaka Sugahara & Yasunori Miyamoto

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  1. Yukino Chiba
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Correspondence to Takayuki Yoshimoto.

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Chiba, Y., Mizoguchi, I., Hasegawa, H. et al. Regulation of myelopoiesis by proinflammatory cytokines in infectious diseases. Cell. Mol. Life Sci. 75, 1363–1376 (2018). https://doi.org/10.1007/s00018-017-2724-5

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