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Strategies for cancer gene therapy using adenoviral vectors

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Abstract

Modification of tumor cells using gene transfer either to enhance host immunity or to act directly on tumor cells is being intensively studied in animal models. Remarkable results have yielded to approved clinical protocols in the treatment of cancer patients using this approach. Several methods of gene delivery have been developed. This article is particularly devoted to the interest of the use of adenoviral vectors in the different strategies of cancer gene therapy.

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Abbreviations

CSF :

Colony-stimulating factor

IL :

Interleukin

pfu :

plaque forming units

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Authors and Affiliations

  1. Génétique des virus oncogènes, Institut Gustave Roussy, PR2, F-94805, Villejuif, France

    V. Descamps, M. -T. Duffour, M. -C. Mathieu, N. Fernandez, L. Cordier, M. A. Abina, E. Kremer, M. Perricaudet & H. Haddada

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  1. V. Descamps
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  2. M. -T. Duffour
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  3. M. -C. Mathieu
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  4. N. Fernandez
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  5. L. Cordier
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  6. M. A. Abina
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  7. E. Kremer
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  8. M. Perricaudet
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  9. H. Haddada
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Descamps, V., Duffour, M.T., Mathieu, M.C. et al. Strategies for cancer gene therapy using adenoviral vectors. J Mol Med 74, 183–189 (1996). https://doi.org/10.1007/BF00204748

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  • DOI: https://doi.org/10.1007/BF00204748

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