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The neurobiology of social environmental risk for schizophrenia: an evolving research field

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Abstract

Introduction

Schizophrenia is a severe and complex brain disorder that usually manifests in early adulthood and disturbs a wide range of human functions. More than 100 years after its initial description, the pathophysiology of the disorder is still incompletely understood. Many epidemiological studies strongly suggest a complex interaction between genetic and environmental risk factors for the development of the disorder. While there is considerable evidence for a social environmental component of this risk, the links between adverse social factors and altered brain function have just come into focus.

Methods

In the present review, we first summarize epidemiological evidence for the significance of social environmental risk factors, outline the role of altered social stress processing in mental illness, and review the latest experimental evidence for the neural correlates of social environmental risk for schizophrenia.

Conclusions

The studies we have discussed in this review provide a selection of the current work in the field. We suggest that many of the social environmental risk factors may impact on perceived social stress and engage neural circuits in the brain whose functional and structural architecture undergoes detrimental change in response to prolonged exposure. We conclude that multidisciplinary approaches involving various fields and thoroughly constructed longitudinal designs are necessary to capture complex structure of social environmental risks.

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Acknowledgments

The authors thank Leila Haddad for her valuable comments on the manuscript. Our work has received funding from the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (Project EU-GEI). EU-GEI is the acronym of the project “European Network of National Schizophrenia Networks Studying Gene Environment Interactions”. A.M.-L. further gratefully acknowledges grant support by Deutsche Forschungsgemeinschaft (SFB 636, KFO 256), German Federal Ministry of Education and Research (NGFN+ MooDs, Bernstein-Programm), and the European Union (NEWMEDS, OPTIMIZE, EU-GEI, EU-AIMS). H.T. gratefully acknowledges grant support by the German Federal Ministry of Education and Research (BMBF 01GQ1102).

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On behalf of all authors, the corresponding author states that there is no conflict of interest.

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  1. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, 68159, Mannheim, Germany

    Ceren Akdeniz, Heike Tost & Andreas Meyer-Lindenberg

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  1. Ceren Akdeniz
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  2. Heike Tost
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Correspondence to Andreas Meyer-Lindenberg.

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Akdeniz, C., Tost, H. & Meyer-Lindenberg, A. The neurobiology of social environmental risk for schizophrenia: an evolving research field. Soc Psychiatry Psychiatr Epidemiol 49, 507–517 (2014). https://doi.org/10.1007/s00127-014-0858-4

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