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In vivo basal ganglia volumetry through application of NURBS models to MR images

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Abstract

Volumetry of basal ganglia (BG) based on magnetic resonance imaging (MRI) provides a sensitive marker in differential diagnosis of BG disorders. The non-uniform rational B-spline (NURBS) surfaces are mathematical representations of three-dimensional structures which have recently been applied in volumetric studies. In this study, a volumetric evaluation of BG based on NURBS was performed in 35 right-handed volunteers. We aimed to compare and validate this technique with respect to manual MRI volumetry and evaluate possible side differences between these structures. Intra- and interobserver biases less than 1.5% demonstrated the method’s stability. The mean percentage differences between NURBS and manual methods were less than 1% for all the structures considered; however, the internal segments of the globus pallidus showed a mean percentage difference of about 1.7%. Rightward asymmetry was found for the caudate nucleus (mean±SD 3.20±0.20 cm3 vs. 3.10±0.19 cm3, P<0.001) for both its head (1.44±0.10 cm3 vs. 1.41±0.09 cm3, P<0.01) and its body/tail (1.73±0.11 cm3 and 1.68±0.12 cm3, P<0.01), and for the globus pallidus (1.23±0.08 cm3 and 1.18±0.09 cm3, P<0.001) for both the internal (0.33±0.05 cm3 vs. 0.31±0.05 cm3, P<0.01) and external (0.90±0.05 cm3 vs. 0.86±0.05 cm3, P<0.001) segments. No volumetric side differences were found for the putamen (3.43±0.14 cm3 vs. 3.39±0.17 cm3, P>0.05). The rightward asymmetry of the BG may be ascribed to the predominant use of the right hand. In conclusion, NURBS is an accurate and reliable method for quantitative volumetry of nervous structures. It offers the advantage of giving a three-dimensional representation of the structures examined.

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Acknowledgement

The authors are grateful to Giuliano Carlesso for skillful technical assistance.

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Authors and Affiliations

  1. Department of Biomorphology and Biotechnologies, University of Messina, Messina, Italy

    Giuseppe Anastasi, Giuseppina Cutroneo & AntonGiulio Vitetta

  2. Department of Neurosurgery, University of Messina, Messina, Italy

    Francesco Tomasello & Sebastiano Lucerna

  3. Study and Treatment Centre for Long-Stay Neurological Patients, Section of Neuroradiology, University of Messina, Messina, Italy

    Placido Bramanti & Paolo Di Bella

  4. Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Via A Gabelli 65, 35127, Padua, Italy

    Andrea Porzionato, Veronica Macchi & Raffaele De Caro

  5. Department of Diagnostic Sciences and Special Therapy, Section of Neuroradiology, University of Padua, Padua, Italy

    Anna Parenti & Veronica Macchi

Authors
  1. Giuseppe Anastasi
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  2. Giuseppina Cutroneo
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  3. Francesco Tomasello
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  4. Sebastiano Lucerna
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  11. Raffaele De Caro
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Correspondence to Raffaele De Caro.

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Anastasi, G., Cutroneo, G., Tomasello, F. et al. In vivo basal ganglia volumetry through application of NURBS models to MR images. Neuroradiology 48, 338–345 (2006). https://doi.org/10.1007/s00234-005-0041-4

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  • DOI: https://doi.org/10.1007/s00234-005-0041-4

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