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Biosynthesis and function of bacterial dialkylresorcinol compounds

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Abstract

This review summarizes the research of bacterially produced dialkylresorcinols (DARs). We will give an overview about the DAR-related research during the last 40 years. Furthermore, a brief introduction into the class of ketosynthases (KS) and examples of these enzymes which show a deviation to the usual catalytic activity is given. One of these is DarB, which is involved in the DAR biosynthesis. The clustering and distribution of the DAR biosynthesis gene clusters (BGC), that has been identified in more than 100 genomes from taxonomically distinct bacteria, is discussed regarding the structures of the biosynthetic products from these BGCs. Finally, the biological activities of described DARs are summarized and possible methods for the detection and structure elucidation of DARs are given.

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Ethical statement

This work was supported by an ERC starting grant to HBB under grant agreement number 311477 and the LOEWE priority program SynChemBio.

Conflict of interest

The authors declare that they have no competing interests.

Human and animal rights and informed consent

This article does not contain any studies with human participants or animals performed by any of the authors.

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Authors and Affiliations

  1. Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany

    Tim A. Schöner, Darko Kresovic & Helge B. Bode

  2. Buchmann Institute for Molecular Life Sciences (BMLS), Goethe Universität Frankfurt, Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany

    Helge B. Bode

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  1. Tim A. Schöner
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  2. Darko Kresovic
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  3. Helge B. Bode
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Correspondence to Helge B. Bode.

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Tim A. Schöner and Darko Kresovic contributed equally to this work.

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Schöner, T.A., Kresovic, D. & Bode, H.B. Biosynthesis and function of bacterial dialkylresorcinol compounds. Appl Microbiol Biotechnol 99, 8323–8328 (2015). https://doi.org/10.1007/s00253-015-6905-6

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