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Host genetic control of mosquito-borne Flavivirus infections

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Abstract

Flaviviruses are arthropod-borne viruses, several of which represent emerging or re-emerging pathogens responsible for widespread infections with consequences ranging from asymptomatic seroconversion to severe clinical diseases and congenital developmental deficits. This variability is due to multiple factors including host genetic determinants, the role of which has been investigated in mouse models and human genetic studies. In this review, we provide an overview of the host genes and variants which modify susceptibility or resistance to major mosquito-borne flaviviruses infections in mice and humans.

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Acknowledgements

C.M. was supported by a fellowship from the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence “Integrative Biology of Emerging Infectious Diseases” (grant n°ANR-10-LABX-62-IBEID). T.C. was supported by a HHMI-Wellcome International Research Scholarship and Institut Pasteur International Network G4 grant.

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  1. Anavaj Sakuntabhai and Xavier Montagutelli have contributed equally to this work.

Authors and Affiliations

  1. Mouse Genetics Laboratory, Department of Genomes and Genetics, Institut Pasteur, Paris, France

    Caroline Manet & Xavier Montagutelli

  2. Functional Genetics of Infectious Diseases Unit, Department of Genomes and Genetics, Institut Pasteur, Paris, France

    Claude Roth, Ahmed Tawfik & Anavaj Sakuntabhai

  3. CNRS, UMR 2000-Génomique Evolutive, Modélisation et Santé, Institut Pasteur, 75015, Paris, France

    Claude Roth, Ahmed Tawfik & Anavaj Sakuntabhai

  4. Immunology Group, Institut Pasteur du Cambodge, International Network of Pasteur Institutes, Phnom Penh, 12201, Cambodia

    Tineke Cantaert

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Manet, C., Roth, C., Tawfik, A. et al. Host genetic control of mosquito-borne Flavivirus infections. Mamm Genome 29, 384–407 (2018). https://doi.org/10.1007/s00335-018-9775-2

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