Skip to main content
Log in

Is β-APP a marker of axonal damage in short-surviving head injury?

  • Regular paper
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Abstract

β-Amyloid precursor protein (β-APP), a normal constituent of neurons which is conveyed by fast axonal transport, has been found to be a useful marker for axonal damage in cases of fatal head injury. Immunocytochemistry for β-APP is a more sensitive technique for identifying axonal injury than conventional silver impregnation. This study was designed to determine how quickly evidenc of axonal damage and bulb formation appears. Using this method a variety of brain areas were studied from 55 patients who died within 24 h of a head injury. Immunocytochemical evidence of axonal injury was first detected after 2 h survival, axonal bulbs were first identified after 3 h survival, and the amount of axonal damage and axonal bulb formation increased the longer the survival time.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: 8 February 1996 / Revised, accepted: 13 May 1996

Rights and permissions

Reprints and permissions

About this article

Cite this article

McKenzie, K., McLellan, D., Gentleman, S. et al. Is β-APP a marker of axonal damage in short-surviving head injury?. Acta Neuropathol 92, 608–613 (1996). https://doi.org/10.1007/s004010050568

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004010050568

Navigation