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The regulation of endothelial nitric oxide synthase by caveolin: a paradigm validated in vivo and shared by the ‘endothelium-derived hyperpolarizing factor’

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Abstract

The endothelium plays a crucial role in the regulation of cardiovascular homeostasis through the release of vasoactive autacoids such as nitric oxide, prostacyclin, and a third factor or pathway termed ‘endothelium-derived hyperpolarizing factor’ (EDHF). Although the functional influence of NO and EDHF is sometimes reciprocal (i.e., their effects decrease or increase with the reduction in vessel diameter, respectively), recent insights led to the identification of caveolae and caveolin as common regulators of their production. In this review, we will first focus on the current understanding of the caveolin/eNOS paradigm and will then detail the most recent findings on the role of caveolae in driving EDHF-signaling pathways.

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Acknowledgments

This work was supported by grants from the Fonds de la Recherche Scientifique Medicale (FRSM) and the Fonds National de la Recherche Scientifique (FNRS), Actions de Recherche Concertée (ARC 09-14-020, ARC 06-11-338) from the Communauté Française de Belgique, The Fondation Jean Leducq (Transatlantic Network for Excellence in Cardiovascular Research), the FP6 funded IP “EUGeneHeart” and the Politique Scientifique Fédérale (IAP P6-30). OF is FNRS Research Director and CD is FNRS Senior Research Associate.

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  1. Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, Université catholique de Louvain, UCL-FATH 5349, 52 Avenue E. Mounier, B-1200, Brussels, Belgium

    Chantal Dessy, Olivier Feron & Jean-Luc Balligand

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  1. Chantal Dessy
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  2. Olivier Feron
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  3. Jean-Luc Balligand
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Correspondence to Chantal Dessy.

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Chantal Dessy, Olivier Feron and Jean-Luc Balligand contributed equally to this work.

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Dessy, C., Feron, O. & Balligand, JL. The regulation of endothelial nitric oxide synthase by caveolin: a paradigm validated in vivo and shared by the ‘endothelium-derived hyperpolarizing factor’. Pflugers Arch - Eur J Physiol 459, 817–827 (2010). https://doi.org/10.1007/s00424-010-0815-3

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