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Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2

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Abstract.

Presenilins play prominent roles in the molecular pathogenesis of Alzheimer's disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes.

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Authors and Affiliations

  1. Department of Molecular Biosciences, The University of Adelaide, SA 5005, Australia, , , , ,

    Casper Groth, Svanhild Nornes, Rosa McCarty, Richard Tamme & Michael Lardelli

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  1. Casper Groth
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  2. Svanhild Nornes
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  3. Rosa McCarty
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  4. Richard Tamme
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  5. Michael Lardelli
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Groth, C., Nornes, S., McCarty, R. et al. Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2 . Dev Genes Evol 212, 486–490 (2002). https://doi.org/10.1007/s00427-002-0269-5

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  • DOI: https://doi.org/10.1007/s00427-002-0269-5

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