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Modeling neurological diseases using iPSC-derived neural cells

iPSC modeling of neurological diseases

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Abstract

Developing efficient models for neurological diseases enables us to uncover disease mechanisms and develop therapeutic strategies to treat them. Discovery of reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the way of modeling human diseases, especially neurological diseases. Currently almost all types of neural cells, including but not limited to neural stem cells, neurons, astrocytes, oligodendrocytes and microglia, can be derived from iPSCs following developmental principles. These iPSC-derived neural cells provide valuable tools for studying neurological disease mechanisms, developing potential therapies, and deepening our understanding of the nervous system.

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Acknowledgements

This work was supported by the Herbert Horvitz Family, Sidell Kagan Foundation, California Institute for Regenerative Medicine TRAN1-08525, and the National Institute of Aging of the National Institutes of Health R01AG056305. J.C is a Herbert Horvitz Fellow. Research reported in this publication was also supported by the National Cancer Institute of the National Institutes of Health under award number P30CA33572. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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  1. Division of Stem Cell Biology, Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA

    Li Li, Jianfei Chao & Yanhong Shi

  2. Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA

    Li Li & Yanhong Shi

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Li, L., Chao, J. & Shi, Y. Modeling neurological diseases using iPSC-derived neural cells. Cell Tissue Res 371, 143–151 (2018). https://doi.org/10.1007/s00441-017-2713-x

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