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Molecular characterization of a rare, human-porcine reassortant rotavirus strain, G11P[6], from Ecuador

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An Erratum to this article was published on 15 December 2009

Abstract

The Pan-American Health Organization established a rotavirus pre-vaccination disease burden and strain surveillance network in Latin America and the Caribbean in 2004. During strain surveillance in Ecuador in 2005–2006, a rare rotavirus genotype, G11P[6], was detected among common strains. Sequencing and phylogenetic analysis of this strain identified a novel lineage of the G11 VP7 gene, most closely related to A253 (91.8% nt identity), a porcine rotavirus strain identified in Venezuela. Most genes of this strain clustered with porcine, human-porcine or bovine-porcine reassortant strains; only VP6 and perhaps NSP2 genes were more closely related to cognate genes of human rotaviruses. Thus, this strain was likely generated by gene reassortment between porcine and human parental strains. Our study provides further evidence that animal rotaviruses play an important role in genetic and antigenic diversity of rotaviruses pathogenic for humans.

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Authors and Affiliations

  1. Association of Public Health Laboratories, Silver Spring, MD, USA

    Krisztián Bányai

  2. Veterinary Medical Research Insititute, Hungarian Academy of Sciences, Budapest, Hungary

    Krisztián Bányai

  3. Gastroenteritis and Respiratory Viruses Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA

    Mathew D. Esona, Tara K. Kerin, Jennifer J. Hull, Slavica Mijatovic & Jon R. Gentsch

  4. Coordinadora Nacional del PAI, Quito, Ecuador

    Nancy Vásconez

  5. Funcionario del Proceso de Ciencia y Tecnología, MSP, Quito, Ecuador

    Carlos Torres

  6. Pan American Health Organization, Immunization Unit, Washington, DC, USA

    Ana M. B. de Filippis

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  1. Krisztián Bányai
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  2. Mathew D. Esona
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  9. Jon R. Gentsch
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Correspondence to Jon R. Gentsch.

Additional information

K. Bányai and M. D. Esona have equally contributed to this work.

An erratum to this article can be found at http://dx.doi.org/10.1007/s00705-009-0531-5

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Bányai, K., Esona, M.D., Kerin, T.K. et al. Molecular characterization of a rare, human-porcine reassortant rotavirus strain, G11P[6], from Ecuador. Arch Virol 154, 1823–1829 (2009). https://doi.org/10.1007/s00705-009-0499-1

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