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S-adenosylmethionine and its products

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Summary.

S-adenosylmethionine is involved in many processes, mainly methylation, polyamine synthesis and radical-based catalysis. It is synthesised through the catalysis of differently regulated enzyme forms. When it is used, the compounds formed are reutilized in different ways: in case of methylation, its end product is homocysteine, which can be remethylated to methionine, give rise to cysteine in the so-called transsulphuration pathway, or be released; in the case of polyamine synthesis, the methylthioadenosine formed is cleaved and gives rise to compounds which can be reutilized; during radical-based catalysis, 5-deoxyadenosine is formed and this, too, is cleaved and reutilized.

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  1. Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Biochimica, Università di Torino, Torino, Italy

    M. A. Grillo & S. Colombatto

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  1. M. A. Grillo
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  2. S. Colombatto
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Authors’ address: Prof. M. A. Grillo Dipartimento di Medicina e Oncologia Sperimentale, Biochimica, Università di Torino, Torino, Italy

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Grillo, M., Colombatto, S. S-adenosylmethionine and its products. Amino Acids 34, 187–193 (2008). https://doi.org/10.1007/s00726-007-0500-9

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  • DOI: https://doi.org/10.1007/s00726-007-0500-9

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