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Reviews of Physiology, Biochemistry and Pharmacology pp 1–22Cite as

Rho-modifying C3-like ADP-ribosyltransferases

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Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 152))

Abstract

C3-like exoenzymes comprise a family of seven bacterial ADP-ribosyltransferases, which selectively modify RhoA, B, and C at asparagine-41. Crystal structures of C3 exoenzymes are available, allowing novel insights into the structure-function relationships of these exoenzymes. Because ADP-ribosylation specifically inhibits the biological functions of the low-molecular mass GTPases, C3 exoenzymes are established pharmacological tools to study the cellular functions of Rho GTPases. Recent studies, however, indicate that the functional consequences of C3-induced ADP-ribosylation are more complex than previously suggested. In the present review the basic properties of C3 exoenzymes are briefly summarized and new findings are reviewed.

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  1. Institute of Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs University Freiburg, Otto-Krayer-Haus, Albertstr. 25, Freiburg, Germany

    K. Aktories, C. Wilde & M. Vogelsgesang

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Aktories, K., Wilde, C., Vogelsgesang, M. (2004). Rho-modifying C3-like ADP-ribosyltransferases. In: Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/s10254-004-0034-4

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