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3D Bioprinting for Tissue and Organ Fabrication

  • Additive Manufacturing of Biomaterials, Tissues, and Organs
  • Published:
Annals of Biomedical Engineering Aims and scope Submit manuscript

Abstract

The field of regenerative medicine has progressed tremendously over the past few decades in its ability to fabricate functional tissue substitutes. Conventional approaches based on scaffolding and microengineering are limited in their capacity of producing tissue constructs with precise biomimetic properties. Three-dimensional (3D) bioprinting technology, on the other hand, promises to bridge the divergence between artificially engineered tissue constructs and native tissues. In a sense, 3D bioprinting offers unprecedented versatility to co-deliver cells and biomaterials with precise control over their compositions, spatial distributions, and architectural accuracy, therefore achieving detailed or even personalized recapitulation of the fine shape, structure, and architecture of target tissues and organs. Here we briefly describe recent progresses of 3D bioprinting technology and associated bioinks suitable for the printing process. We then focus on the applications of this technology in fabrication of biomimetic constructs of several representative tissues and organs, including blood vessel, heart, liver, and cartilage. We finally conclude with future challenges in 3D bioprinting as well as potential solutions for further development.

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Acknowledgments

The authors gratefully acknowledge funding from the Office of Naval Research Young National Investigator Award, the National Institutes of Health (EB012597, AR057837, DE021468, HL099073, R56AI105024), and the Presidential Early Career Award for Scientists and Engineers (PECASE).

Conflict of interest

The authors declare no conflict of interest.

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    Authors and Affiliations

    1. Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA

      Yu Shrike Zhang, Kan Yue, Julio Aleman, Kamyar Mollazadeh-Moghaddam, Syeda Mahwish Bakht, Jingzhou Yang, Weitao Jia, Valeria Dell’Erba, Pribpandao Assawes, Su Ryon Shin, Mehmet Remzi Dokmeci & Ali Khademhosseini

    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

      Yu Shrike Zhang, Kan Yue, Julio Aleman, Kamyar Mollazadeh-Moghaddam, Syeda Mahwish Bakht, Jingzhou Yang, Weitao Jia, Valeria Dell’Erba, Pribpandao Assawes, Su Ryon Shin, Mehmet Remzi Dokmeci & Ali Khademhosseini

    3. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA

      Yu Shrike Zhang, Su Ryon Shin, Mehmet Remzi Dokmeci & Ali Khademhosseini

    4. Comsats Institute of Information and Technology, Islamabad, 45550, Pakistan

      Syeda Mahwish Bakht

    5. School of Mechanical and Chemical Engineering, University of Western Australia, Perth, WA, 6009, Australia

      Jingzhou Yang

    6. Department of Orthopedic Surgery, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai, 200233, People’s Republic of China

      Weitao Jia

    7. Department of Biomedical Engineering, Politecnico di Torino, 10129, Turin, Italy

      Valeria Dell’Erba

    8. Division of Vascular & Interventional Radiology, Mayo Clinic, Scottsdale, AZ, 85259, USA

      Rahmi Oklu

    9. Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul, 143-701, Republic of Korea

      Ali Khademhosseini

    10. Department of Physics, King Abdulaziz University, Jeddah, 21569, Saudi Arabia

      Ali Khademhosseini

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    1. Yu Shrike Zhang
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    Correspondence to Ali Khademhosseini.

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    Associate Editor Jos Malda oversaw the review of this article.

    Kan Yue, Julio Aleman, Kamyar Mollazadeh-Moghaddam, Syeda Mahwish Bakht authors contributed equally to this work.

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    Zhang, Y.S., Yue, K., Aleman, J. et al. 3D Bioprinting for Tissue and Organ Fabrication. Ann Biomed Eng 45, 148–163 (2017). https://doi.org/10.1007/s10439-016-1612-8

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