Abstract
Background
Small-bowel capsule endoscopy (SBCE) is an invaluable imaging method for the small bowel. The Lewis score (LS) and the Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI) have been developed to standardize the reporting of small-bowel inflammation. Fecal calprotectin (FC) represents a highly reliable biomarker of intestinal inflammation.
Aim
To assess the performance of the two SBCE inflammation scoring systems by correlating them with FC. Furthermore, to define threshold levels for CECDAI.
Methods
Retrospective study; patients who underwent SBCE and had FC measurement shortly before or after SBCE. LS and CECDAI were calculated by a single reviewer and correlated [Spearman’s (r s )] with the FC results. Linear regression analysis was used to identify threshold levels for CECDAI.
Results
Forty-nine patients; three subgroups A, B and C (based on FC levels <100, 100–200, and ≥200 μg/g, respectively). LS appears to correlate with FC (r s = 0.448, p = 0.0014), unlike CECDAI, which does not demonstrate significant correlation (r s = 0.245, p = 0.089). Strongly positive correlation between FC and LS was observed in subgroup A (r s = 0.68, p = 0.0047), while in subgroups B and C, neither LS nor CECDAI showed correlation with FC. Significant correlation between LS and CECDAI was demonstrated (r s = 0. 6324, p < 0.0001). Linear regression analysis demonstrates that LS thresholds of 135 and 790 correspond with CECDAI levels of 3.8 and 5.8, respectively.
Conclusions
LS performs better than CECDAI in describing small-bowel inflammation, especially at FC levels of <100 μg/g. Furthermore, CECDAI levels of 3.8 and 5.8 seem to correspond to LS thresholds of 135 and 790, respectively.
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References
Triester SL, Leighton JA, Leontiadis GI, et al. A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with nonstricturing small bowel Crohn’s disease. Am J Gastroenterol. 2006;101:954–964.
Kornbluth A, Colombel JF, Leighton JA, et al. ICCE. ICCE consensus for inflammatory bowel disease. Endoscopy. 2005;37:1051–1054.
Lewis BS. Expanding role of capsule endoscopy in inflammatory bowel disease. World J Gastroenterol. 2008;14:4137–4141.
Lewis BS, Eisen GM, Friedman S. A pooled analysis to evaluate results of capsule endoscopy trials. Endoscopy. 2005;37:960–965.
Doherty GA, Moss AC, Cheifetz AS. Capsule endoscopy in suspected Crohn’s disease: “yield” does not equal “diagnosis”. Am J Gastroenterol. 2010;105:2111.
Røseth AG, Fagerhol MK, Aadland E, et al. Assessment of the neutrophil dominating protein calprotectin in feces. A methodologic study. Scand J Gastroenterol. 1992;27:793–798.
Logan R. Faecal calprotectin for the diagnosis of inflammatory bowel disease. BMJ. 2010;341:c3636. doi:10.1136/bmj.c3636.
Langhorst J, Elsenbruch S, Koelzer J, et al. Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices. Am J Gastroenterol. 2008;103:162–169.
Sipponen T, Björkesten CG, Färkkilä M, et al. Faecal calprotectin and lactoferrin are reliable surrogate markers of endoscopic response during Crohn’s disease treatment. Scand J Gastroenterol. 2010;45:325–331.
van Rheenen PF, Van de Vijver E, Fidler V. Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis. BMJ. 2010;341:c3369. doi:10.1136/bmj.c3369.
Summerton CB, Longlands MG, Wiener K, et al. Faecal calprotectin: a marker of inflammation throughout the intestinal tract. Eur J Gastroenterol Hepatol. 2002;14:841–845.
Lucendo AJ, Guagnozzi D. Small bowel video capsule endoscopy in Crohn’s disease: what have we learned in the last ten years? World J Gastrointest Endosc. 2011;3:23–29.
Gal E, Geller A, Fraser G, et al. Assessment and validation of the new capsule endoscopy Crohn’s disease activity index (CECDAI). Dig Dis Sci. 2008;53:1933–1937.
Gralnek IM, Defranchis R, Seidman E, et al. Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change. Aliment Pharmacol Ther. 2008;27:146–154.
Koulaouzidis A, Douglas S, Rogers MA, et al. Fecal calprotectin: a selection tool for small bowel capsule endoscopy in suspected IBD with prior negative bidirectional endoscopy. Scand J Gastroenterol. 2011;46:561–566.
Jensen MD, Kjeldsen J, Nathan T. Fecal calprotectin is equally sensitive in Crohn’s disease affecting the small bowel and colon. Scand J Gastroenterol. 2011;46:694–700.
Zippi M, Al Ansari N, Siliquini F, et al. Correlation between faecal calprotectin and magnetic resonance imaging (MRI) in the evaluation of inflammatory pattern in Crohn’s disease. Clin Ter. 2010;161:e53–e56.
Konikoff MR, Denson LA. Role of fecal calprotectin as a biomarker of intestinal inflammation in inflammatory bowel disease. Inflamm Bowel Dis. 2006;12:524–534.
Bourreille A, Ignjatovic A, Aabakken L, World Organisation of Digestive Endoscopy (OMED) and the European Crohn’s and Colitis Organisation (ECCO), et al. Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensus. Endoscopy. 2009;41:618–637.
Sidhu R, Sanders DS, Wilson P, et al. Faecal lactoferrin, capsule endoscopy and Crohn’s disease. Is there a three way relationship? A pilot study. J Gastrointestin Liver Dis. 2010;19:257–260.
van Langenberg DR, Gearry RB, Wong HL, et al. The potential value of faecal lactoferrin as a screening test in hospitalized patients with diarrhoea. Intern Med J. 2010;40:819–827.
Schoepfer AM, Beglinger C, Straumann A, et al. Non-invasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices. Am J Gastroenterol. 2008;103:162–169.
Røseth AG, Schmidt PN, Fagerhol MK. Correlation between faecal excretion of indium-111-labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease. Scand J Gastroenterol. 1999;34:50–54.
Tibble J, Teahon K, Thjodleifsson B, et al. A simple method for assessing intestinal inflammation in Crohn’s disease. Gut. 2000;47:506–513.
Dolwani S, Metzner M, Wassell JJ, et al. Diagnostic accuracy of faecal calprotectin estimation in prediction of abnormal small bowel radiology. Aliment Pharmacol Ther. 2004;20:615–621.
Sprakes MB, Hamlin PJ, Ford AC. Utility of fecal calprotectin in differentiating active inflammatory bowel disease from coexistent irritable bowel syndrome. Am J Gastroenterol. 2011;106:166.
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The authors report no conflicts of interest in relevance to this work. The authors alone are responsible for the content and writing of the paper.
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Koulaouzidis, A., Douglas, S. & Plevris, J.N. Lewis Score Correlates More Closely with Fecal Calprotectin Than Capsule Endoscopy Crohn’s Disease Activity Index. Dig Dis Sci 57, 987–993 (2012). https://doi.org/10.1007/s10620-011-1956-8
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DOI: https://doi.org/10.1007/s10620-011-1956-8