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Studies of threespine stickleback developmental evolution: progress and promise

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Abstract

A promising route for understanding the origin and diversification of organismal form is through studies at the intersection of evolution and development (evo-devo). While much has been learned over the last two decades concerning macroevolutionary patterns of developmental change, a fundamental gap in the evo-devo synthesis is the integration of mathematical population and quantitative genetics with studies of how genetic variation in natural populations affects developmental processes. This micro-evo-devo synthesis requires model organisms with which to ask empirical questions. Threespine stickleback fish (Gasterosteus aculeatus), long a model for studying behavior, ecology and evolution, is emerging as a prominent model micro-evo-devo system. Research on stickleback over the last decade has begun to address the genetic basis of morphological variation and sex determination, and much of this work has important implications for understanding the genetics of speciation. In this paper we review recent threespine stickleback micro-evo-devo results, and outline the resources that have been developed to make this synthesis possible. The prospects for stickleback research to speed the micro-(and macro-) evo-devo syntheses are great, and this workhorse model system is well situated to continue contributing to our understanding of the generation of diversity in organismal form for many more decades.

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Acknowledgements

We thank A. Amores, S. Bassham, M. Bell, M. Currey, A. Force, S. Foster, C. Kimmel, C. Hulslander, J. Thornton, and F. von Hippel for discussions that enhanced this review. We also thank Norman Johnson and an anonymous reviewer for helpful comments on this manuscript. We are grateful to Yasuko Honjo for translating the Ikeda (1934) paper from its original Japanese into English. Support for our work is provided by NSF grants IBN 0236239 and IBN 9728587, and NIH grants R01RR10715 and 5 F32 GM020892. The University of Oregon’s program in Evolution, Development and Genomics is supported by NSF Integrative Graduate Education and Research Traineeship (IGERT) grant DGE 9972830. Funding from this IGERT has nurtured our and our student’s explorations into evo-devo questions.

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  1. Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR, 97403-5289, USA

    William A. Cresko, Katrina L. McGuigan & Patrick C. Phillips

  2. Institute of Neuroscience, University of Oregon, Eugene, OR, 97403-1254, USA

    William A. Cresko, Katrina L. McGuigan & John H. Postlethwait

  3. School of Integrative Biology, University of Queensland, St. Lucia, Queensland, 4072, Australia

    Katrina L. McGuigan

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  1. William A. Cresko
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Correspondence to William A. Cresko.

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Cresko, W.A., McGuigan, K.L., Phillips, P.C. et al. Studies of threespine stickleback developmental evolution: progress and promise. Genetica 129, 105–126 (2007). https://doi.org/10.1007/s10709-006-0036-z

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