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Stereotactic model of the electrical distribution within the internal globus pallidus during deep brain stimulation

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Abstract

Deep brain stimulation (DBS) of the internal globus pallidus (GPi) is an established surgical technique for the treatment of movement disorders. The objective of this study was to propose a computational stereotactic model of the electrical distribution around the electrode within the targeted GPi in order to optimize parameter adjustment in clinical practice. The outline of the GPi can be defined precisely by using stereotactic magnetic resonance imaging (MRI) and from this it is possible to model its three-dimensional structure. The electrode and the distribution of the patient-specific parameters can then be co-registered with the GPi volume. By using this methodology, it is possible to visualize and measure the relationship between the electrical distribution of patient-specific parameters and the morphology of the GPi. The model could be applied in clinical practice to help determine the threshold for achieving a therapeutic effect and consequently may aid in optimizing parameter settings for individual patients.

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Acknowledgement

This work was supported by grants from IBM France, Products and Solutions Support Center department (PSSC).

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Authors and Affiliations

  1. CHRU Montpellier, Service de Neurochirurgie, Hôpital Gui de Chauliac, Unité de Recherche sur les Mouvements Anormaux, 80 Avenue Augustin Fliche, 34295, Montpellier Cedex 05, France

    Xavier Vasques, Laura Cif, Sophie Gavarini & Philippe Coubes

  2. IGF, Montpellier, 34094, France

    Xavier Vasques, Laura Cif, Sophie Gavarini & Philippe Coubes

  3. CNRS UMR5203, Montpellier, 34094, France

    Xavier Vasques, Laura Cif, Sophie Gavarini & Philippe Coubes

  4. INSERM, U661, Montpellier, 34094, France

    Xavier Vasques, Laura Cif, Sophie Gavarini & Philippe Coubes

  5. Université Montpellier I, Montpellier, 34094, France

    Xavier Vasques, Laura Cif, Sophie Gavarini & Philippe Coubes

  6. Laboratoire de Physique Théorique et Astroparticules, UMR CNRS 5207, Université Montpellier II, Montpellier, France

    Gerard Mennessier

  7. Deep Computing Europe, IBM Montpellier, Montpellier, France

    Olivier Hess

Authors
  1. Xavier Vasques
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  2. Laura Cif
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  3. Olivier Hess
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  4. Sophie Gavarini
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  5. Gerard Mennessier
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  6. Philippe Coubes
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Correspondence to Philippe Coubes.

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Action Editor: Charles Wilson

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Vasques, X., Cif, L., Hess, O. et al. Stereotactic model of the electrical distribution within the internal globus pallidus during deep brain stimulation. J Comput Neurosci 26, 109–118 (2009). https://doi.org/10.1007/s10827-008-0101-y

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  • DOI: https://doi.org/10.1007/s10827-008-0101-y

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