Abstract
Extracellular nucleotides, and ATP in particular, are cellular signal substances involved in the control of numerous (patho)physiological mechanisms. They provoke nucleotide receptor-mediated mechanisms in select target cells. But nucleotides can considerably expand their range of action. They function as primary messengers in intercellular communication by stimulating the release of other extracellular messenger substances. These in turn activate additional cellular mechanisms through their own receptors. While this applies also to other extracellular messengers, its omnipresence in the vertebrate organism is an outstanding feature of nucleotide signaling. Intercellular messenger substances released by nucleotides include neurotransmitters, hormones, growth factors, a considerable variety of other proteins including enzymes, numerous cytokines, lipid mediators, nitric oxide, and reactive oxygen species. Moreover, nucleotides activate or co-activate growth factor receptors. In the case of hormone release, the initially paracrine or autocrine nucleotide-mediated signal spreads through to the entire organism. The examples highlighted in this commentary suggest that acting as ubiquitous triggers of intercellular messenger release is one of the major functional roles of extracellular nucleotides. While initiation of messenger release by nucleotides has been unraveled in many contexts, it may have been overlooked in others. It can be anticipated that additional nucleotide-driven messenger functions will be uncovered with relevance for both understanding physiology and development of therapy.
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References
Ralevic V, Burnstock G (1998) Receptors for purines and pyrimidines. Pharmacol Rev 50(3):413–492
Burnstock G, Verkhratsky A (2009) Evolutionary origins of the purinergic signalling system. Acta Physiol (Oxf) 195(4):415–447. doi:10.1111/j.1748-1716.2009.01957.x
Verkhratsky A, Burnstock G (2014) Biology of purinergic signalling: its ancient evolutionary roots, its omnipresence and its multiple functional significance. Bioessays 36(7):697–705. doi:10.1002/bies.201400024
Burnstock G (2013) Introduction to purinergic signalling in the brain. Adv Exp Med Biol 986:1–12. doi:10.1007/978-94-007-4719-7_1
Butt AM (2011) ATP: a ubiquitous gliotransmitter integrating neuron-glial networks. Semin Cell Dev Biol 22(2):205–213. doi:10.1016/j.semcdb.2011.02.023
Zimmermann H (2011) Purinergic signaling in neural development. Semin Cell Dev Biol 22(2):194–204. doi:10.1016/j.semcdb.2011.02.007
Tsuda M, Tozaki-Saitoh H, Inoue K (2010) Pain and purinergic signaling. Brain Res Rev 63(1–2):222–232. doi:10.1016/j.brainresrev.2009.11.003
Burnstock G (2014) Purinergic signalling in endocrine organs. Purinergic Signal 10(1):189–231. doi:10.1007/s11302-013-9396-x
Nakatsuka T, Gu JG (2006) P2X purinoceptors and sensory transmission. Pflugers Arch 452(5):598–607. doi:10.1007/s00424-006-0057-6
Housley GD, Bringmann A, Reichenbach A (2009) Purinergic signaling in special senses. Trends Neurosci 32(3):128–141. doi:10.1016/j.tins.2009.01.001
Birch RE, Schwiebert EM, Peppiatt-Wildman CM et al (2013) Emerging key roles for P2X receptors in the kidney. Front Physiol 4:262. doi:10.3389/fphys.2013.00262
Burnstock G (2014) Purinergic signalling in the urinary tract in health and disease. Purinergic Signal 10(1):103–155. doi:10.1007/s11302-013-9395-y
Vaughn BP, Robson SC, Longhi MS (2014) Purinergic signaling in liver disease. Dig Dis 32(5):516–524. doi:10.1159/000360498
Gachet C (2008) P2 receptors, platelet function and pharmacological implications. Thromb Haemost 99(3):466–472. doi:10.1160/TH07-11-0673
Burnstock G (2009) Purinergic regulation of vascular tone and remodelling. Auton Autacoid Pharmacol 29(3):63–72. doi:10.1111/j.1474-8673.2009.00435.x
Burnstock G, Boeynaems J (2014) Purinergic signalling and immune cells. Purinergic Signal 10(4):529–564. doi:10.1007/s11302-014-9427-2
Idzko M, Ferrari D, Eltzschig HK (2014) Nucleotide signalling during inflammation. Nature 509(7500):310–317. doi:10.1038/nature13085
Rumney RMH, Wang N, Agrawal A et al (2012) Purinergic signalling in bone. Front Endocrinol 3:116. doi:10.3389/fendo.2012.00116
Burnstock G, Arnett TR, Orriss IR (2013) Purinergic signalling in the musculoskeletal system. Purinergic Signal 9(4):541–572. doi:10.1007/s11302-013-9381-4
Burnstock G, Brouns I, Adriaensen D et al (2012) Purinergic signaling in the airways. Pharmacol Rev 64(4):834–868. doi:10.1124/pr.111.005389
Goyal RK, Sullivan MP, Chaudhury A (2013) Progress in understanding of inhibitory purinergic neuromuscular transmission in the gut. Neurogastroenterol Motil 25(3):203–207. doi:10.1111/nmo.12090
Novak I (2011) Purinergic signalling in epithelial ion transport: regulation of secretion and absorption. Acta Physiol (Oxf) 202(3):501–522. doi:10.1111/j.1748-1716.2010.02225.x
Burnstock G (2008) Purinergic signalling and disorders of the central nervous system. Nat Rev Drug Discov 7(7):575–590. doi:10.1038/nrd2605
Erlinge D, Burnstock G (2008) P2 receptors in cardiovascular regulation and disease. Purinergic Signal 4(1):1–20. doi:10.1007/s11302-007-9078-7
Di Virgilio F (2012) Purines, purinergic receptors, and cancer. Cancer Res 72(21):5441–5447. doi:10.1158/0008-5472. CAN-12-1600
Jacob F, Pérez Novo C, Bachert C et al (2013) Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses. Purinergic Signal 9(3):285–306. doi:10.1007/s11302-013-9357-4
Burnstock G, Pelleg A (2015) Cardiac purinergic signalling in health and disease. Purinergic Signal 11(1):1–46. doi:10.1007/s11302-014-9436-1
Roberts JA, Vial C, Digby HR et al (2006) Molecular properties of P2X receptors. Pflugers Arch 452(5):486–500. doi:10.1007/s00424-006-0073-6
von Kügelgen I, Harden TK (2011) Molecular pharmacology, physiology, and structure of the P2Y receptors. Adv Pharmacol 61:373–415. doi:10.1016/B978-0-12-385526-8.00012-6
Erb L, Weisman GA (2012) Coupling of P2Y receptors to G proteins and other signaling pathways. Wiley Interdiscip Rev Membr Transp Signal 1(6):789–803. doi:10.1002/wmts.62
Jacobson KA, Balasubramanian R, Deflorian F et al (2012) G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions. Purinergic Signal 8(3):419–436. doi:10.1007/s11302-012-9294-7
Jacobson KA, Paoletta S, Katritch V et al (2015) Nucleotides acting at P2Y receptors: connecting structure and function. Mol Pharmacol 88(2):220–230. doi:10.1124/mol.114.095711
Cinkilic O, King BF, van der Giet M et al (2001) Selective agonism of group I P2X receptors by dinucleotides dependent on a single adenine moiety. J Pharmacol Exp Ther 299(1):131–136
Erb L, Liao Z, Seye CI et al (2006) P2 receptors: intracellular signaling. Pflugers Arch 452(5):552–562. doi:10.1007/s00424-006-0069-2
Bartlett R, Stokes L, Sluyter R (2014) The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease. Pharmacol Rev 66(3):638–675. doi:10.1124/pr.113.008003
Alves LA, de Melo Reis RA, de Souza CAM et al (2014) The P2X7 receptor: shifting from a low- to a high-conductance channel—an enigmatic phenomenon? Biochim Biophys Acta 1838(10):2578–2587. doi:10.1016/j.bbamem.2014.05.015
Browne LE, Compan V, Bragg L et al (2013) P2X7 receptor channels allow direct permeation of nanometer-sized dyes. J Neurosci 33(8):3557–3566. doi:10.1523/JNEUROSCI.2235-12.2013
Costa-Junior HM, Sarmento Vieira F, Coutinho-Silva R (2011) C terminus of the P2X7 receptor: treasure hunting. Purinergic Signal 7(1):7–19. doi:10.1007/s11302-011-9215-1
Zimmermann H, Zebisch M, Sträter N (2012) Cellular function and molecular structure of ecto-nucleotidases. Purinergic Signal 8(3):437–502. doi:10.1007/s11302-012-9309-4
Corriden R, Insel PA (2010) Basal release of ATP: an autocrine-paracrine mechanism for cell regulation. Sci Signal 3(104):re1. doi:10.1126/scisignal.3104re1
Lazarowski ER, Sesma JI, Seminario-Vidal L et al (2011) Molecular mechanisms of purine and pyrimidine nucleotide release. Adv Pharmacol 61:221–261. doi:10.1016/B978-0-12-385526-8.00008-4
Lazarowski ER (2012) Vesicular and conductive mechanisms of nucleotide release. Purinergic Signal 8(3):359–373. doi:10.1007/s11302-012-9304-9
Cisneros-Mejorado A, Pérez-Samartín A, Gottlieb M et al (2015) ATP signaling in brain: release, excitotoxicity and potential therapeutic targets. Cell Mol Neurobiol 35(1):1–6. doi:10.1007/s10571-014-0092-3
Orellana JA, Stehberg J (2014) Hemichannels: new roles in astroglial function. Front Physiol 5:193. doi:10.3389/fphys.2014.00193
Takano T, He W, Han X et al (2014) Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices. Glia 62(1):78–95. doi:10.1002/glia.22588
Khakh BS, Gittermann D, Cockayne DA et al (2003) ATP modulation of excitatory synapses onto interneurons. J Neurosci 23(19):7426–7437
Cho J, Choi I, Jang I (2010) P2X7 receptors enhance glutamate release in hippocampal hilar neurons. Neuroreport 21(13):865–870. doi:10.1097/WNR.0b013e32833d9142
Khakh BS, Henderson G (1998) ATP receptor-mediated enhancement of fast excitatory neurotransmitter release in the brain. Mol Pharmacol 54(2):372–378
Shigetomi E, Kato F (2004) Action potential-independent release of glutamate by Ca2+ entry through presynaptic P2X receptors elicits postsynaptic firing in the brainstem autonomic network. J Neurosci 24(12):3125–3135. doi:10.1523/JNEUROSCI.0090-04.2004
Gu JG, MacDermott AB (1997) Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature 389(6652):749–753. doi:10.1038/39639
León D, Sánchez-Nogueiro J, Marín-García P et al (2008) Glutamate release and synapsin-I phosphorylation induced by P2X7 receptors activation in cerebellar granule neurons. Neurochem Int 52(6):1148–1159. doi:10.1016/j.neuint.2007.12.004
Marcoli M, Cervetto C, Paluzzi P et al (2008) P2X7 pre-synaptic receptors in adult rat cerebrocortical nerve terminals: a role in ATP-induced glutamate release. J Neurochem 105(6):2330–2342. doi:10.1111/j.1471-4159.2008.05322.x
Miras-Portugal MT, Díaz-Hernández M, Giráldez L et al (2003) P2X7 receptors in rat brain: presence in synaptic terminals and granule cells. Neurochem Res 28(10):1597–1605
Jeremic A, Jeftinija K, Stevanovic J et al (2001) ATP stimulates calcium-dependent glutamate release from cultured astrocytes. J Neurochem 77(2):664–675. doi:10.1046/j.1471-4159.2001.00272.x
Zhang Q, Pangrsic T, Kreft M et al (2004) Fusion-related release of glutamate from astrocytes. J Biol Chem 279(13):12724–12733. doi:10.1074/jbc.M312845200
Domercq M, Brambilla L, Pilati E et al (2006) P2Y1 receptor-evoked glutamate exocytosis from astrocytes: control by tumor necrosis factor-alpha and prostaglandins. J Biol Chem 281(41):30684–30696. doi:10.1074/jbc.M606429200
Zeng J, Liu X, Zhang J et al (2008) P2Y1 receptor-mediated glutamate release from cultured dorsal spinal cord astrocytes. J Neurochem 106(5):2106–2118. doi:10.1111/j.1471-4159.2008.05560.x
Duan S, Anderson CM, Keung EC et al (2003) P2X7 receptor-mediated release of excitatory amino acids from astrocytes. J Neurosci 23(4):1320–1328
Fellin T, Pozzan T, Carmignoto G (2006) Purinergic receptors mediate two distinct glutamate release pathways in hippocampal astrocytes. J Biol Chem 281(7):4274–4284. doi:10.1074/jbc.M510679200
Jeftinija SD, Jeftinija KV (1998) ATP stimulates release of excitatory amino acids from cultured Schwann cells. Neuroscience 82(3):927–934
Stigliani S, Zappettini S, Raiteri L et al (2006) Glia re-sealed particles freshly prepared from adult rat brain are competent for exocytotic release of glutamate. J Neurochem 96(3):656–668. doi:10.1111/j.1471-4159.2005.03631.x
Pan H, Chou Y, Sun SH (2015) P2X7 R-mediated Ca2+-independent D-serine release via pannexin-1 of the P2X7 R-pannexin-1 complex in astrocytes. Glia 63(5):877–893. doi:10.1002/glia.22790
Rhee JS, Wang ZM, Nabekura J et al (2000) ATP facilitates spontaneous glycinergic IPSC frequency at dissociated rat dorsal horn interneuron synapses. J Physiol 524(2):471–483. doi:10.1111/j.1469-7793.2000.t01-1-00471.x
Wang ZM, Katsurabayashi S, Rhee JS et al (2001) Substance P abolishes the facilitatory effect of ATP on spontaneous glycine release in neurons of the trigeminal nucleus pars caudalis. J Neurosci 21(9):2983–2991
Jameson HS, Pinol RA, Mendelowitz D (2008) Purinergic P2X receptors facilitate inhibitory GABAergic and glycinergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Brain Res 1224:53–62. doi:10.1016/j.brainres.2008.06.012
Gómez-Villafuertes R, Gualix J, Miras-Portugal MT (2001) Single GABAergic synaptic terminals from rat midbrain exhibit functional P2X and dinucleotide receptors, able to induce GABA secretion. J Neurochem 77(1):84–93
Hugel S, Schlichter R (2000) Presynaptic P2X receptors facilitate inhibitory GABAergic transmission between cultured rat spinal cord dorsal horn neurons. J Neurosci 20(6):2121–2130
Bhattacharya A, Vavra V, Svobodova I et al (2013) Potentiation of inhibitory synaptic transmission by extracellular ATP in rat suprachiasmatic nuclei. J Neurosci 33(18):8035–8044. doi:10.1523/JNEUROSCI.4682-12.2013
Wirkner K, Köfalvi A, Fischer W et al (2005) Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia. J Neurochem 95(5):1421–1437. doi:10.1111/j.1471-4159.2005.03465.x
Sperlágh B, Köfalvi A, Deuchars J et al (2002) Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus. J Neurochem 81(6):1196–1211
Vavra V, Bhattacharya A, Zemkova H (2011) Facilitation of glutamate and GABA release by P2X receptor activation in supraoptic neurons from freshly isolated rat brain slices. Neuroscience 188:1–12. doi:10.1016/j.neuroscience.2011.04.067
Wang C, Chang Y, Kuo J et al (2002) Activation of P2X7 receptors induced [3H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl−/HCO3 −-dependent mechanism. Glia 37(1):8–18
Allgaier C, Pullmann F, Schobert A et al (1994) P2 purinoceptors modulating noradrenaline release from sympathetic neurons in culture. Eur J Pharmacol 252(2):R7–R8
Boehm S (1994) Noradrenaline release from rat sympathetic neurons evoked by P2-purinoceptor activation. Naunyn Schmiedeberg's Arch Pharmacol 350(5):454–458
von Kügelgen I, Nörenberg W, Meyer A et al (1999) Role of action potentials and calcium influx in ATP- and UDP-induced noradrenaline release from rat cultured sympathetic neurones. Naunyn Schmiedeberg's Arch Pharmacol 359(5):360–369
Sesti C, Broekman MJ, Drosopoulos JHF et al (2002) Ecto-nucleotidase in cardiac sympathetic nerve endings modulates ATP-mediated feedback of norepinephrine release. J Pharmacol Exp Ther 300(2):605–611
Machida T, Heerdt PM, Reid AC et al (2005) Ectonucleoside triphosphate diphosphohydrolase 1/CD39, localized in neurons of human and porcine heart, modulates ATP-induced norepinephrine exocytosis. J Pharmacol Exp Ther 313(2):570–577. doi:10.1124/jpet.104.081240
Queiroz G, Talaia C, Gonçalves J (2003) ATP modulates noradrenaline release by activation of inhibitory P2Y receptors and facilitatory P2X receptors in the rat vas deferens. J Pharmacol Exp Ther 307(2):809–815. doi:10.1124/jpet.103.054809
Sperlágh B, Erdélyi F, Szabó G et al (2000) Local regulation of [3H]-noradrenaline release from the isolated guinea-pig right atrium by P2X-receptors located on axon terminals. Br J Pharmacol 131(8):1775–1783. doi:10.1038/sj.bjp.0703757
Papp L, Balázsa T, Köfalvi A et al (2004) P2X receptor activation elicits transporter-mediated noradrenaline release from rat hippocampal slices. J Pharmacol Exp Ther 310(3):973–980. doi:10.1124/jpet.104.066712
Inoue K, Nakazawa K, Fujimori K et al (1989) Extracellular adenosine 5’-triphosphate-evoked norepinephrine secretion not relating to voltage-gated Ca channels in pheochromocytoma PC12 cells. Neurosci Lett 106(3):294–299
Majid MA, Okajima F, Kondo Y (1992) Characterization of ATP receptor which mediates norepinephrine release in PC12 cells. Biochim Biophys Acta 1136(3):283–289
Rhoads AR, Parui R, Vu ND et al (1993) ATP-induced secretion in PC12 cells and photoaffinity labeling of receptors. J Neurochem 61(5):1657–1666
Oda H, Murayama T, Nomura Y (1995) Effects of protein kinase C and A activation on ATP-stimulated release of [3H]noradrenaline from PC12 cells. J Biochem 118(2):325–331
Nakazawa K, Inoue K (1992) Roles of Ca2+ influx through ATP-activated channels in catecholamine release from pheochromocytoma PC12 cells. J Neurophysiol 68(6):2026–2032
Zhang YX, Yamashita H, Ohshita T et al (1995) ATP increases extracellular dopamine level through stimulation of P2Y purinoceptors in the rat striatum. Brain Res 691(1–2):205–212
Krügel U, Kittner H, Illes P (1999) Adenosine 5’-triphosphate-induced dopamine release in the rat nucleus accumbens in vivo. Neurosci Lett 265(1):49–52
Krügel U, Kittner H, Illes P (2001) Mechanisms of adenosine 5’-triphosphate-induced dopamine release in the rat nucleus accumbens in vivo. Synapse 39(3):222–232. doi:10.1002/1098-2396(20010301)39:3<222:AID-SYN1003>3.0.CO;2-R
Koizumi S, Ikeda M, Inoue K et al (1995) Enhancement by zinc of ATP-evoked dopamine release from rat pheochromocytoma PC12 cells. Brain Res 673(1):75–82
Kinnamon SC, Finger TE (2013) A taste for ATP: neurotransmission in taste buds. Front Cell Neurosci 7:264. doi:10.3389/fncel.2013.00264
Huang YA, Dando R, Roper SD (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. J Neurosci 29(44):13909–13918. doi:10.1523/JNEUROSCI.2351-09.2009
Guthrie PB, Knappenberger J, Segal M et al (1999) ATP released from astrocytes mediates glial calcium waves. J Neurosci 19(2):520–528
Anderson CM, Bergher JP, Swanson RA (2004) ATP-induced ATP release from astrocytes. J Neurochem 88(1):246–256
Wang Z, Haydon PG, Yeung ES (2000) Direct observation of calcium-independent intercellular ATP signaling in astrocytes. Anal Chem 72(9):2001–2007. doi:10.1021/ac9912146
Fam SR, Gallagher CJ, Salter MW (2000) P2Y1 purinoceptor-mediated Ca2+ signaling and Ca2+ wave propagation in dorsal spinal cord astrocytes. J Neurosci 20(8):2800–2808
John GR, Scemes E, Suadicani SO et al (1999) IL-1beta differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels. Proc Natl Acad Sci U S A 96(20):11613–11618
Gallagher CJ, Salter MW (2003) Differential properties of astrocyte calcium waves mediated by P2Y1 and P2Y2 receptors. J Neurosci 23(17):6728–6739
Choo AM, Miller WJ, Chen Y et al (2013) Antagonism of purinergic signalling improves recovery from traumatic brain injury. Brain 136(Pt 1):65–80. doi:10.1093/brain/aws286
Kuga N, Sasaki T, Takahara Y et al (2011) Large-scale calcium waves traveling through astrocytic networks in vivo. J Neurosci 31(7):2607–2614. doi:10.1523/JNEUROSCI.5319-10.2011
Lemos JR, Ortiz-Miranda SI, Cuadra AE et al (2012) Modulation/physiology of calcium channel sub-types in neurosecretory terminals. Cell Calcium 51(3–4):284–292. doi:10.1016/j.ceca.2012.01.008
Troadec JD, Thirion S, Nicaise G et al (1998) ATP-evoked increases in [Ca2+]i and peptide release from rat isolated neurohypophysial terminals via a P2X2 purinoceptor. J Physiol 511(Pt 1):89–103
Lemos JR, Wang G (2000) Excitatory versus inhibitory modulation by ATP of neurohypophysial terminal activity in the rat. Exp Physiol 85:67S–74S
Knott TK, Marrero HG, Custer EE et al (2008) Endogenous ATP potentiates only vasopressin secretion from neurohypophysial terminals. J Cell Physiol 217(1):155–161. doi:10.1002/jcp.21485
Custer EE, Knott TK, Cuadra AE et al (2012) P2X purinergic receptor knockout mice reveal endogenous ATP modulation of both vasopressin and oxytocin release from the intact neurohypophysis. J Neuroendocrinol 24(4):674–680. doi:10.1111/j.1365-2826.2012.02299.x
Kapoor JR, Sladek CD (2000) Purinergic and adrenergic agonists synergize in stimulating vasopressin and oxytocin release. J Neurosci 20(23):8868–8875
Song Z, Gomes DA, Stevens W (2009) Role of purinergic P2Y1 receptors in regulation of vasopressin and oxytocin secretion. Am J Physiol Regul Integr Comp Physiol 297(2):R478–R484. doi:10.1152/ajpregu.00163.2009
Song Z, Sladek CD (2006) Site of ATP and phenylephrine synergistic stimulation of vasopressin release from the hypothalamo-neurohypophyseal system. J Neuroendocrinol 18(4):266–272. doi:10.1111/j.1365-2826.2006.01411.x
Gomes DA, Song Z, Stevens W et al (2009) Sustained stimulation of vasopressin and oxytocin release by ATP and phenylephrine requires recruitment of desensitization-resistant P2X purinergic receptors. Am J Physiol Regul Integr Comp Physiol 297(4):R940–R949. doi:10.1152/ajpregu.00358.2009
Chen ZP, Kratzmeier M, Levy A et al (1995) Evidence for a role of pituitary ATP receptors in the regulation of pituitary function. Proc Natl Acad Sci U S A 92(11):5219–5223
Tomić M, Jobin RM, Vergara LA et al (1996) Expression of purinergic receptor channels and their role in calcium signaling and hormone release in pituitary gonadotrophs. Integration of P2 channels in plasma membrane- and endoplasmic reticulum-derived calcium oscillations. J Biol Chem 271(35):21200–21208
Zemkova H, Balik A, Jiang Y et al (2006) Roles of purinergic P2X receptors as pacemaking channels and modulators of calcium-mobilizing pathway in pituitary gonadotrophs. Mol Endocrinol 20(6):1423–1436. doi:10.1210/me.2005-0508
Barnea A, Cho G, Katz BM (1991) A putative role for extracellular ATP: facilitation of 67copper uptake and of copper stimulation of the release of luteinizing hormone-releasing hormone from median eminence explants. Brain Res 541(1):93–97
Terasawa E, Keen KL, Grendell RL et al (2005) Possible role of 5’-adenosine triphosphate in synchronization of Ca2+ oscillations in primate luteinizing hormone-releasing hormone neurons. Mol Endocrinol 19(11):2736–2747. doi:10.1210/me.2005-0034
Nuñez L, Villalobos C, Frawley LS (1997) Extracellular ATP as an autocrine/paracrine regulator of prolactin release. Am J Physiol 272(6 Pt 1):E1117–E1123
He M, Gonzalez-Iglesias AE, Stojilkovic SS (2003) Role of nucleotide P2 receptors in calcium signaling and prolactin release in pituitary lactotrophs. J Biol Chem 278(47):46270–46277. doi:10.1074/jbc.M309005200
Zemkova H, Kucka M, Li S et al (2010) Characterization of purinergic P2X4 receptor channels expressed in anterior pituitary cells. Am J Physiol Endocrinol Metab 298(3):E644–E651. doi:10.1152/ajpendo.00558.2009
Jia C, Hegg CC (2010) NPY mediates ATP-induced neuroproliferation in adult mouse olfactory epithelium. Neurobiol Dis 38(3):405–413. doi:10.1016/j.nbd.2010.02.013
Kanekar S, Jia C, Hegg CC (2009) Purinergic receptor activation evokes neurotrophic factor neuropeptide Y release from neonatal mouse olfactory epithelial slices. J Neurosci Res 87(6):1424–1434. doi:10.1002/jnr.21954
Jia C, Hayoz S, Hutch CR et al (2013) An IP3R3- and NPY-expressing microvillous cell mediates tissue homeostasis and regeneration in the mouse olfactory epithelium. PLoS ONE 8(3), e58668. doi:10.1371/journal.pone.0058668
Nishi H (1999) Two different P2Y receptors linked to steroidogenesis in bovine adrenocortical cells. Jpn J Pharmacol 81(2):194–199
Hoey DE, Nicol M, Williams BC et al (1994) Primary cultures of bovine inner zone adrenocortical cells secrete cortisol in response to adenosine 5’-triphosphate, adenosine 5’-diphosphate, and uridine 5’-triphosphate via a nucleotide receptor that may be coupled to two signal generation systems. Endocrinology 135(4):1553–1560. doi:10.1210/endo.135.4.7925117
Kawamura M, Matsui T, Niitsu A et al (1991) Extracellular ATP stimulates steroidogenesis in bovine adrenocortical fasciculata cells via P2 purinoceptors. Jpn J Pharmacol 56(4):543–545
Kawamura M, Niitsu A, Nishi H et al (2001) Extracellular ATP potentiates steroidogenic effect of adrenocorticotropic hormone in bovine adrenocortical fasciculata cells. Jpn J Pharmacol 85(4):376–381
Xu L, Enyeart JJ (1999) Purine and pyrimidine nucleotides inhibit a noninactivating K+ current and depolarize adrenal cortical cells through a G protein-coupled receptor. Mol Pharmacol 55(2):364–376
Nishi H, Arai H, Momiyama T (2013) NCI-H295R, a human adrenal cortex-derived cell line, expresses purinergic receptors linked to Ca2+-mobilization/influx and cortisol secretion. PLoS ONE 8(8), e71022. doi:10.1371/journal.pone.0071022
Foresta C, Rossato M, Nogara A et al (1996) Role of P2-purinergic receptors in rat Leydig cell steroidogenesis. Biochem J 320(Pt 2):499–504
Rossato M, Merico M, Bettella A et al (2001) Extracellular ATP stimulates estradiol secretion in rat Sertoli cells in vitro: modulation by external sodium. Mol Cell Endocrinol 178(1–2):181–187
Jia C, Cussen AR, Hegg CC (2011) ATP differentially upregulates fibroblast growth factor 2 and transforming growth factor α in neonatal and adult mice: effect on neuroproliferation. Neuroscience 177:335–346. doi:10.1016/j.neuroscience.2010.12.039
Jin H, Eun SY, Lee JS et al (2014) P2Y2 receptor activation by nucleotides released from highly metastatic breast cancer cells increases tumor growth and invasion via crosstalk with endothelial cells. Breast Cancer Res 16(5):R77. doi:10.1186/bcr3694
Klein K, Aeschlimann A, Jordan S et al (2012) ATP induced brain-derived neurotrophic factor expression and release from osteoarthritis synovial fibroblasts is mediated by purinergic receptor P2X4. PLoS ONE 7(5), e36693. doi:10.1371/journal.pone.0036693
Beggs S, Trang T, Salter MW (2012) P2X4R+ microglia drive neuropathic pain. Nat Neurosci 15(8):1068–1073. doi:10.1038/nn.3155
Trang T, Beggs S, Salter MW (2011) Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain. Neuron Glia Biol 7(1):99–108. doi:10.1017/S1740925X12000087
Trang T, Beggs S, Wan X et al (2009) P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation. J Neurosci 29(11):3518–3528. doi:10.1523/JNEUROSCI.5714-08.2009
Ulmann L, Hatcher JP, Hughes JP et al (2008) Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain. J Neurosci 28(44):11263–11268. doi:10.1523/JNEUROSCI.2308-08.2008
Verderio C, Bianco F, Blanchard MP et al (2006) Cross talk between vestibular neurons and Schwann cells mediates BDNF release and neuronal regeneration. Brain Cell Biol 35(2–3):187–201. doi:10.1007/s11068-007-9011-6
Lopez-Castejon G, Theaker J, Pelegrin P et al (2010) P2X7 receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases. J Immunol 185(4):2611–2619. doi:10.4049/jimmunol.1000436
Clark AK, Wodarski R, Guida F et al (2010) Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor. Glia 58(14):1710–1726. doi:10.1002/glia.21042
Murphy N, Lynch MA (2012) Activation of the P2X7 receptor induces migration of glial cells by inducing cathepsin B degradation of tissue inhibitor of metalloproteinase 1. J Neurochem 123(5):761–770. doi:10.1111/jnc.12031
Idzko M, Panther E, Bremer HC et al (2003) Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils. Br J Pharmacol 138(7):1244–1250. doi:10.1038/sj.bjp.0705145
Joo YN, Jin H, Eun SY et al (2014) P2Y2R activation by nucleotides released from the highly metastatic breast cancer cell MDA-MB-231 contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment. Oncotarget 5(19):9322–9334
Khine AA, Del Sorbo L, Vaschetto R et al (2006) Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway. Blood 107(7):2936–2942. doi:10.1182/blood-2005-06-2314
Warny M, Aboudola S, Robson SC et al (2001) P2Y6 nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide. J Biol Chem 276(28):26051–26056. doi:10.1074/jbc.M102568200
Grbic DM, Degagné É, Larrivée J et al (2012) P2Y6 receptor contributes to neutrophil recruitment to inflamed intestinal mucosa by increasing CXC chemokine ligand 8 expression in an AP-1-dependent manner in epithelial cells. Inflamm Bowel Dis 18(8):1456–1469. doi:10.1002/ibd.21931
Grbic DM, Degagne E, Langlois C et al (2008) Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP. J Immunol 180(4):2659–2668. doi:10.4049/jimmunol.180.4.2659
Relvas LJM, Bouffioux C, Marcet B et al (2009) Extracellular nucleotides and interleukin-8 production by ARPE cells: potential role of danger signals in blood-retinal barrier activation. Invest Ophthalmol Vis Sci 50(3):1241–1246. doi:10.1167/iovs.08-1902
Braganhol E, Kukulski F, Lévesque SA et al (2015) Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells. Biochim Biophys Acta 1852(1):120–130. doi:10.1016/j.bbadis.2014.10.014
Trubiani O, Horenstein AL, Caciagli F et al (2014) Expression of P2X7 ATP receptor mediating the IL8 and CCL20 release in human periodontal ligament stem cells. J Cell Biochem 115(6):1138–1146. doi:10.1002/jcb.24756
Kukulski F, Bahrami F, Ben Yebdri F et al (2011) NTPDase1 controls IL-8 production by human neutrophils. J Immunol 187(2):644–653. doi:10.4049/jimmunol.1002680
Kruse R, Säve S, Persson K (2012) Adenosine triphosphate induced P2Y2 receptor activation induces proinflammatory cytokine release in uroepithelial cells. J Urol 188(6):2419–2425. doi:10.1016/j.juro.2012.07.095
Müller T, Bayer H, Myrtek D et al (2005) The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion. Am J Respir Cell Mol Biol 33(6):601–609. doi:10.1165/rcmb.2005-0181OC
Shieh C, Heinrich A, Serchov T et al (2014) P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia. Glia 62(4):592–607. doi:10.1002/glia.22628
Shiratori M, Tozaki-Saitoh H, Yoshitake M et al (2010) P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways. J Neurochem 114(3):810–819. doi:10.1111/j.1471-4159.2010.06809.x
Kataoka A, Tozaki-Saitoh H, Koga Y et al (2009) Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT. J Neurochem 108(1):115–125. doi:10.1111/j.1471-4159.2008.05744.x
Solini A, Chiozzi P, Morelli A et al (1999) Human primary fibroblasts in vitro express a purinergic P2X7 receptor coupled to ion fluxes, microvesicle formation and IL-6 release. J Cell Sci 112(Pt 3):297–305
Solle M, Labasi J, Perregaux DG et al (2001) Altered cytokine production in mice lacking P2X7 receptors. J Biol Chem 276(1):125–132. doi:10.1074/jbc.M006781200
Shigemoto-Mogami Y, Koizumi S, Tsuda M et al (2001) Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. J Neurochem 78(6):1339–1349. doi:10.1046/j.1471-4159.2001.00514.x
Bergamin LS, Braganhol E, Figueiró F et al (2015) Involvement of purinergic system in the release of cytokines by macrophages exposed to glioma-conditioned medium. J Cell Biochem 116(5):721–729. doi:10.1002/jcb.25018
Xu H, Wu B, Jiang F et al (2013) High fatty acids modulate P2X7 expression and IL-6 release via the p38 MAPK pathway in PC12 cells. Brain Res Bull 94:63–70. doi:10.1016/j.brainresbull.2013.02.002
Inoue K, Hosoi J, Denda M (2007) Extracellular ATP has stimulatory effects on the expression and release of IL-6 via purinergic receptors in normal human epidermal keratinocytes. J Invest Dermatol 127(2):362–371. doi:10.1038/sj.jid.5700526
Yoshida H, Kobayashi D, Ohkubo S et al (2006) ATP stimulates interleukin-6 production via P2Y receptors in human HaCaT keratinocytes. Eur J Pharmacol 540(1–3):1–9. doi:10.1016/j.ejphar.2006.04.008
Fujita T, Tozaki-Saitoh H, Inoue K (2009) P2Y1 receptor signaling enhances neuroprotection by astrocytes against oxidative stress via IL-6 release in hippocampal cultures. Glia 57(3):244–257. doi:10.1002/glia.20749
Uratsuji H, Tada Y, Kawashima T et al (2012) P2Y6 receptor signaling pathway mediates inflammatory responses induced by monosodium urate crystals. J Immunol 188(1):436–444. doi:10.4049/jimmunol.1003746
Sakaki H, Fujiwaki T, Tsukimoto M et al (2013) P2X4 receptor regulates P2X7 receptor-dependent IL-1β and IL-18 release in mouse bone marrow-derived dendritic cells. Biochem Biophys Res Commun 432(3):406–411. doi:10.1016/j.bbrc.2013.01.135
Nagakura C, Negishi Y, Tsukimoto M et al (2014) Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6 production by human keratinocytes. Toxicology 322:61–68. doi:10.1016/j.tox.2014.03.010
Ishimaru M, Yusuke N, Tsukimoto M et al (2014) Purinergic signaling via P2Y receptors up-mediates IL-6 production by liver macrophages/Kupffer cells. J Toxicol Sci 39(3):413–423
Marriott I, Inscho EW, Bost KL (1999) Extracellular uridine nucleotides initiate cytokine production by murine dendritic cells. Cell Immunol 195(2):147–156. doi:10.1006/cimm.1999.1531
Seo DR, Kim SY, Kim KY et al (2008) Cross talk between P2 purinergic receptors modulates extracellular ATP-mediated interleukin-10 production in rat microglial cells. Exp Mol Med 40(1):19–26. doi:10.3858/emm.2008.40.1.19
Seo DR, Kim KY, Lee YB (2004) Interleukin-10 expression in lipopolysaccharide-activated microglia is mediated by extracellular ATP in an autocrine fashion. Neuroreport 15(7):1157–1161
Ishibashi T, Dakin KA, Stevens B et al (2006) Astrocytes promote myelination in response to electrical impulses. Neuron 49(6):823–832. doi:10.1016/j.neuron.2006.02.006
Cohen JE, Fields RD (2009) Activity-dependent neuron–glial signaling by ATP and leukemia-inhibitory factor promotes hippocampal glial cell development. Neuron Glia Biol 4:43–55. doi:10.1017/S1740925X09000076
Tonetti M, Sturla L, Giovine M et al (1995) Extracellular ATP enhances mRNA levels of nitric oxide synthase and TNF-alpha in lipopolysaccharide-treated RAW 264.7 murine macrophages. Biochem Biophys Res Commun 214(1):125–130
Xia M, Zhu Y (2013) FOXO3a involvement in the release of TNF-α stimulated by ATP in spinal cord astrocytes. J Mol Neurosci 51(3):792–804. doi:10.1007/s12031-013-0067-8
Suzuki T (2004) Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia. J Neurosci 24(1):1–7. doi:10.1523/JNEUROSCI.3792-03.2004
Hide I, Tanaka M, Inoue A et al (2000) Extracellular ATP triggers tumor necrosis factor-α release from rat microglia. J Neurochem 75(3):965–972. doi:10.1046/j.1471-4159.2000.0750965.x
Ikeda M, Tsuno S, Sugiyama T et al (2013) Ca2+ spiking activity caused by the activation of store-operated Ca2+ channels mediates TNF-α release from microglial cells under chronic purinergic stimulation. Biochim Biophys Acta 1833(12):2573–2585. doi:10.1016/j.bbamcr.2013.06.022
Pupovac A, Foster CM, Sluyter R (2013) Human P2X7 receptor activation induces the rapid shedding of CXCL16. Biochem Biophys Res Commun 432(4):626–631. doi:10.1016/j.bbrc.2013.01.134
Sengstake S (2006) CD21 and CD62L shedding are both inducible via P2X7Rs. Int Immunol 18(7):1171–1178. doi:10.1093/intimm/dxl051
Elliott JI, Surprenant A, Marelli-Berg FM et al (2005) Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes. Nat Cell Biol 7(8):808–816. doi:10.1038/ncb1279
Gu B, Bendall LJ, Wiley JS (1998) Adenosine triphosphate-induced shedding of CD23 and L-selectin (CD62L) from lymphocytes is mediated by the same receptor but different metalloproteases. Blood 92(3):946–951
Jamieson GP, Snook MB, Thurlow PJ et al (1996) Extracellular ATP causes of loss of L-selectin from human lymphocytes via occupancy of P2Z purinocepters. J Cell Physiol 166(3):637–642. doi:10.1002/(SICI)1097-4652(199603)166:3<637:AID-JCP19>3.0.CO;2-3
Schleiffenbaum B, Spertini O, Tedder TF (1992) Soluble L-selectin is present in human plasma at high levels and retains functional activity. J Cell Biol 119(1):229–238
Sluyter R, Wiley JS (2002) Extracellular adenosine 5’-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors. Int Immunol 14(12):1415–1421
Pupovac A, Geraghty NJ, Watson D et al (2015) Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells. Immunol Cell Biol 93(1):77–85. doi:10.1038/icb.2014.69
Gu BJ (2006) Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor. Blood 107(12):4946–4953. doi:10.1182/blood-2005-07-2994
Camden JM, Schrader AM, Camden RE et al (2005) P2Y2 nucleotide receptors enhance secretase-dependent amyloid precursor protein processing. J Biol Chem 280(19):18696–18702. doi:10.1074/jbc.M500219200
Suzuki A, Kotoyori J, Oiso Y et al (1993) Prostaglandin E2 is a potential mediator of extracellular ATP action in osteoblast-like cells. Cell Adhes Commun 1(2):113–118
Lazarowski ER, Boucher RC, Harden TK (1994) Calcium-dependent release of arachidonic acid in response to purinergic receptor activation in airway epithelium. Am J Physiol 266(2 Pt 1):C406–C415
Chen WC, Chen CC (1998) ATP-induced arachidonic acid release in cultured astrocytes is mediated by Gi protein coupled P2Y1 and P2Y2 receptors. Glia 22(4):360–370
Strokin M, Sergeeva M, Reiser G (2003) Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP and Ca2+. Br J Pharmacol 139(5):1014–1022. doi:10.1038/sj.bjp.0705326
Cheng S, Lee I, Lin C et al (2013) ATP mediates NADPH oxidase/ROS generation and COX-2/PGE2 expression in A549 cells: role of P2 receptor-dependent STAT3 activation. PLoS ONE 8(1), e54125. doi:10.1371/journal.pone.0054125
Lin C, Lin W, Cheng S et al (2012) Transactivation of EGFR/PI3K/Akt involved in ATP-induced inflammatory protein expression and cell motility. J Cell Physiol 227(4):1628–1638. doi:10.1002/jcp.22880
Berenbaum F, Humbert L, Bereziat G et al (2003) Concomitant recruitment of ERK1/2 and p38 MAPK signalling pathway is required for activation of cytoplasmic phospholipase A2 via ATP in articular chondrocytes. J Biol Chem 278(16):13680–13687. doi:10.1074/jbc.M211570200
Xia M, Zhu Y (2011) Signaling pathways of ATP-induced PGE2 release in spinal cord astrocytes are EGFR transactivation-dependent. Glia 59(4):664–674. doi:10.1002/glia.21138
Ruan YC, Wang Z, Du JY et al (2008) Regulation of smooth muscle contractility by the epithelium in rat vas deferens: role of ATP-induced release of PGE 2. J Physiol 586(20):4843–4857. doi:10.1113/jphysiol.2008.154096
Hammer LW, Overstreet CR, Choi J et al (2003) ATP stimulates the release of prostacyclin from perfused veins isolated from the hamster hindlimb. Am J Physiol Regul Integr Comp Physiol 285(1):R193–R199. doi:10.1152/ajpregu.00468.2002
Lustig KD, Erb L, Landis DM et al (1992) Mechanisms by which extracellular ATP and UTP stimulate the release of prostacyclin from bovine pulmonary artery endothelial cells. Biochim Biophys Acta 1134(1):61–72
Forsberg EJ, Feuerstein G, Shohami E et al (1987) Adenosine triphosphate stimulates inositol phospholipid metabolism and prostacyclin formation in adrenal medullary endothelial cells by means of P2-purinergic receptors. Proc Natl Acad Sci U S A 84(16):5630–5634
Carter TD, Hallam TJ, Cusack NJ et al (1988) Regulation of P2Y-purinoceptor-mediated prostacyclin release from human endothelial cells by cytoplasmic calcium concentration. Br J Pharmacol 95(4):1181–1190
Armstrong PCJ, Leadbeater PD, Chan MV et al (2011) In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation. J Thromb Haemost 9(3):552–561. doi:10.1111/j.1538-7836.2010.04160.x
Kahner BN, Shankar H, Murugappan S et al (2006) Nucleotide receptor signaling in platelets. J Thromb Haemost 4(11):2317–2326. doi:10.1111/j.1538-7836.2006.02192.x
Pearce B, Murphy S, Jeremy J et al (1989) ATP-evoked Ca2+ mobilisation and prostanoid release from astrocytes: P2-purinergic receptors linked to phosphoinositide hydrolysis. J Neurochem 52(3):971–977
Barberà-Cremades M, Baroja-Mazo A, Gomez AI et al (2012) P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release. FASEB J 26(7):2951–2962. doi:10.1096/fj.12-205765
Kobayashi N, Nishi T, Hirata T et al (2006) Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner. J Lipid Res 47(3):614–621. doi:10.1194/jlr.M500468-JLR200
Cossenza M, Socodato R, Portugal CC et al (2014) Nitric oxide in the nervous system: biochemical, developmental, and neurobiological aspects. Vitam Horm 96:79–125. doi:10.1016/B978-0-12-800254-4.00005-2
Codocedo JF, Godoy JA, Poblete MI et al (2013) ATP induces NO production in hippocampal neurons by P2X7 receptor activation independent of glutamate signaling. PLoS ONE 8(3), e57626. doi:10.1371/journal.pone.0057626
Lowe M, Park SJ, Nurse CA et al (2013) Purinergic stimulation of carotid body efferent glossopharyngeal neurones increases intracellular Ca2+ and nitric oxide production. Exp Physiol 98(7):1199–1212. doi:10.1113/expphysiol.2013.072058
Yukawa H, Shen J, Harada N et al (2005) Acute effects of glucocorticoids on ATP-induced Ca2+ mobilization and nitric oxide production in cochlear spiral ganglion neurons. Neuroscience 130(2):485–496. doi:10.1016/j.neuroscience.2004.09.037
Busnardo C, Ferreira-Junior NC, Cruz JC et al (2013) Cardiovascular responses to ATP microinjected into the paraventricular nucleus are mediated by nitric oxide and NMDA glutamate receptors in awake rats. Exp Physiol 98(10):1411–1421. doi:10.1113/expphysiol.2013.073619
Hung Y, Leung Y, Lin N et al (2015) P2 purinergic receptor activation of neuronal nitric oxide synthase and guanylyl cyclase in the dorsal facial area of the medulla increases blood flow in the common carotid arteries of cats. Neuroscience 286:231–241. doi:10.1016/j.neuroscience.2014.11.043
Murakami K, Nakamura Y, Yoneda Y (2003) Potentiation by ATP of lipopolysaccharide-stimulated nitric oxide production in cultured astrocytes. Neuroscience 117(1):37–42. doi:10.1016/S0306-4522(02)00804-7
Li N, Sul J, Haydon PG (2003) A calcium-induced calcium influx factor, nitric oxide, modulates the refilling of calcium stores in astrocytes. J Neurosci 23(32):10302–10310
Mehta B, Begum G, Joshi NB et al (2008) Nitric oxide-mediated modulation of synaptic activity by astrocytic P2Y receptors. J Gen Physiol 132(3):339–349. doi:10.1085/jgp.200810043
Ohtani Y, Minami M, Satoh M (2000) Expression of inducible nitric oxide synthase mRNA and production of nitric oxide are induced by adenosine triphosphate in cultured rat microglia. Neurosci Lett 293(1):72–74. doi:10.1016/S0304-3940(00)01478-6
Dibaj P, Nadrigny F, Steffens H et al (2010) NO mediates microglial response to acute spinal cord injury under ATP control in vivo. Glia 58(9):1133–1144. doi:10.1002/glia.20993
Harada N (2010) Role of nitric oxide on purinergic signalling in the cochlea. Purinergic Signal 6(2):211–220. doi:10.1007/s11302-010-9186-7
Burnstock G (2002) Purinergic signaling and vascular cell proliferation and death. Arterioscler Thromb Vasc Biol 22(3):364–373. doi:10.1161/hq0302.105360
Pfeiffer ZA, Guerra AN, Hill LM et al (2007) Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation. Free Radic Biol Med 42(10):1506–1516. doi:10.1016/j.freeradbiomed.2007.02.010
Zhu S, Wang Y, Wang X et al (2014) Emodin inhibits ATP-induced IL-1β secretion, ROS production and phagocytosis attenuation in rat peritoneal macrophages via antagonizing P2X7 receptor. Pharm Biol 52(1):51–57. doi:10.3109/13880209.2013.810648
Cruz CM, Rinna A, Forman HJ et al (2007) ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem 282(5):2871–2879. doi:10.1074/jbc.M608083200
Díaz-Vegas A, Campos CA, Contreras-Ferrat A et al (2015) ROS production via P2Y1-PKC-NOX2 is triggered by extracellular ATP after electrical stimulation of skeletal muscle cells. PLoS ONE 10(6), e0129882. doi:10.1371/journal.pone.0129882
Abbracchio MP, Burnstock G, Verkhratsky A et al (2009) Purinergic signalling in the nervous system: an overview. Trends Neurosci 32(1):19–29. doi:10.1016/j.tins.2008.10.001
Khakh BS, North RA (2012) Neuromodulation by extracellular ATP and P2X receptors in the CNS. Neuron 76(1):51–69. doi:10.1016/j.neuron.2012.09.024
Papp L, Vizi ES, Sperlágh B (2004) Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor−/− mice. Neuroreport 15(15):2387–2391
Mongin AA, Kimelberg HK (2002) ATP potently modulates anion channel-mediated excitatory amino acid release from cultured astrocytes. Am J Physiol Cell Physiol 283(2):C569–C578. doi:10.1152/ajpcell.00438.2001
Kimelberg HK (2004) Increased release of excitatory amino acids by the actions of ATP and peroxynitrite on volume-regulated anion channels (VRACs) in astrocytes. Neurochem Int 45(4):511–519. doi:10.1016/j.neuint.2003.11.002
Rudkouskaya A, Chernoguz A, Haskew-Layton RE et al (2008) Two conventional protein kinase C isoforms, alpha and beta I, are involved in the ATP-induced activation of volume-regulated anion channel and glutamate release in cultured astrocytes. J Neurochem 105(6):2260–2270. doi:10.1111/j.1471-4159.2008.05312.x
Haydon PG (2001) GLIA: listening and talking to the synapse. Nat Rev Neurosci 2(3):185–193. doi:10.1038/35058528
Newman EA (2003) New roles for astrocytes: regulation of synaptic transmission. Trends Neurosci 26(10):536–542. doi:10.1016/S0166-2236(03)00237-6
Rodrigues RJ, Tomé AR, Cunha RA (2015) ATP as a multi-target danger signal in the brain. Front Neurosci 9:148. doi:10.3389/fnins.2015.00148
Calabrese F, Rossetti AC, Racagni G et al (2014) Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity. Front Cell Neurosci 8:430. doi:10.3389/fncel.2014.00430
Leal G, Afonso PM, Salazar IL et al (2015) Regulation of hippocampal synaptic plasticity by BDNF. Brain Res 1621:82–101. doi:10.1016/j.brainres.2014.10.019
Vasiljeva O, Reinheckel T, Peters C et al (2007) Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Curr Pharm Des 13(4):387–403
Wagner JG, Roth RA (2000) Neutrophil migration mechanisms, with an emphasis on the pulmonary vasculature. Pharmacol Rev 52(3):349–374
Mahalingam S, Karupiah G (1999) Chemokines and chemokine receptors in infectious diseases. Immunol Cell Biol 77(6):469–475. doi:10.1046/j.1440-1711.1999.00858.x
Akdis M, Burgler S, Crameri R et al (2011) Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases. J Allergy Clin Immunol 127(3):701–721. doi:10.1016/j.jaci.2010.11.050, e1-70
Gabel CA (2007) P2 purinergic receptor modulation of cytokine production. Purinergic Signal 3(1–2):27–38. doi:10.1007/s11302-006-9034-y
Izquierdo MC, Martin-Cleary C, Fernandez-Fernandez B et al (2014) CXCL16 in kidney and cardiovascular injury. Cytokine Growth Factor Rev 25(3):317–325. doi:10.1016/j.cytogfr.2014.04.002
Cooper AM, Hobson PS, Jutton MR et al (2012) Soluble CD23 controls IgE synthesis and homeostasis in human B cells. J Immunol 188(7):3199–3207. doi:10.4049/jimmunol.1102689
Frémeaux-Bacchi V, Aubry JP, Bonnefoy JY et al (1998) Soluble CD21 induces activation and differentiation of human monocytes through binding to membrane CD23. Eur J Immunol 28(12):4268–4274. doi:10.1002/(SICI)1521-4141(199812)28:12<4268:AID-IMMU4268>3.0.CO;2-9
Lazarov O, Demars MP (2012) All in the family: how the APPs regulate neurogenesis. Front Neurosci 6:81. doi:10.3389/fnins.2012.00081
Sakata D, Yao C, Narumiya S (2010) Prostaglandin E2, an immunoactivator. J Pharmacol Sci 112(1):1–5. doi:10.1254/jphs.09R03CP
Pyne NJ, Long JS, Lee SC et al (2009) New aspects of sphingosine 1-phosphate signaling in mammalian cells. Adv Enzyme Regul 49(1):214–221. doi:10.1016/j.advenzreg.2009.01.011
Florenzano F, Viscomi MT, Amadio S et al (2008) Do ATP and NO interact in the CNS? Prog Neurobiol 84(1):40–56. doi:10.1016/j.pneurobio.2007.10.004
Culotta E, Koshland DE (1992) NO news is good news. Science 258(5090):1862–1865
Gundersen V, Storm-Mathisen J, Bergersen LH (2015) Neuroglial transmission. Physiol Rev 95(3):695–726. doi:10.1152/physrev.00024.2014
D’Autréaux B, Toledano MB (2007) ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol 8(10):813–824. doi:10.1038/nrm2256
Li W, Qiu Y, Zhang H et al (2015) P2Y2 receptor and EGFR cooperate to promote prostate cancer cell invasion via ERK1/2 pathway. PLoS ONE 10(7), e0133165. doi:10.1371/journal.pone.0133165
Liu J, Liao Z, Camden J et al (2004) Src homology 3 binding sites in the P2Y2 nucleotide receptor interact with Src and regulate activities of Src, proline-rich tyrosine kinase 2, and growth factor receptors. J Biol Chem 279(9):8212–8218. doi:10.1074/jbc.M312230200
Ratchford AM, Baker OJ, Camden JM et al (2010) P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells. J Biol Chem 285(10):7545–7555. doi:10.1074/jbc.M109.078170
Luke TM, Hexum TD (2008) UTP and ATP increase extracellular signal-regulated kinase 1/2 phosphorylation in bovine chromaffin cells through epidermal growth factor receptor transactivation. Purinergic Signal 4(4):323–330. doi:10.1007/s11302-008-9098-y
Sham D, Wesley UV, Hristova M et al (2013) ATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17. PLoS ONE 8(1), e54391. doi:10.1371/journal.pone.0054391
Yin J, Xu K, Zhang J et al (2007) Wound-induced ATP release and EGF receptor activation in epithelial cells. J Cell Sci 120(Pt 5):815–825. doi:10.1242/jcs.03389
Buvinic S, Bravo-Zehnder M, Boyer JL et al (2007) Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells. J Cell Sci 120(24):4289–4301. doi:10.1242/jcs.03490
Weisman GA, Ajit D, Garrad R et al (2012) Neuroprotective roles of the P2Y2 receptor. Purinergic Signal 8(3):559–578. doi:10.1007/s11302-012-9307-6
Seye CI, Yu N, Gonzalez FA et al (2004) The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 (KDR/Flk-1). J Biol Chem 279(34):35679–35686. doi:10.1074/jbc.M401799200
Peterson TS, Camden JM, Wang Y et al (2010) P2Y2 nucleotide receptor-mediated responses in brain cells. Mol Neurobiol 41(2–3):356–366. doi:10.1007/s12035-010-8115-7
Liao Z, Cao C, Wang J et al (2014) The P2Y2 receptor interacts with VE-Cadherin and VEGF receptor-2 to regulate Rac1 activity in endothelial cells. J Biomed Sci Eng 7(14):1105–1121. doi:10.4236/jbise.2014.714109
Rumjahn SM, Yokdang N, Baldwin KA et al (2009) Purinergic regulation of vascular endothelial growth factor signaling in angiogenesis. Br J Cancer 100(9):1465–1470. doi:10.1038/sj.bjc.6604998
Arthur DB, Akassoglou K, Insel PA (2006) P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation. Biochem Biophys Res Commun 347(3):678–682. doi:10.1016/j.bbrc.2006.06.141
van Kolen K, Gilany K, Moens L et al (2006) P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1. Cell Signal 18(8):1169–1181. doi:10.1016/j.cellsig.2005.09.005
Rodriguez-Candela JL, Martin-Hernandez D, Castilla-Cortazar T (1963) Stimulation of insulin secretion in vitro by adenosine triphosphate. Nature 197:1304
Levine RA, Oyama S, Kagan A et al (1970) Stimulation of insulin and growth hormone secretion by adenine nucleotides in primates. J Lab Clin Med 75(1):30–36
Cieślak M, Roszek K (2014) Purinergic signaling in the pancreas and the therapeutic potential of ecto-nucleotidases in diabetes. Acta Biochim Pol 61(4):655–662
Öhman J, Erlinge D (2013) At the center of the circle: purinergic signaling in the autocrine loops of pancreatic islets. WIREs Membr Transport Signaling 2(3):107–119. doi:10.1002/wmts.82
Petit P, Lajoix A, Gross R (2009) P2 purinergic signalling in the pancreatic β-cell: control of insulin secretion and pharmacology. Eur J Pharm Sci 37(2):67–75. doi:10.1016/j.ejps.2009.01.007
Hazama A, Hayashi S, Okada Y (1998) Cell surface measurements of ATP release from single pancreatic beta cells using a novel biosensor technique. Pflugers Arch 437(1):31–35
Leitner JW, Sussman KE, Vatter AE et al (1975) Adenine nucleotides in the secretory granule fraction of rat islets. Endocrinology 96(3):662–677. doi:10.1210/endo-96-3-662
Chapal J, Hillaire-Buys D, Bertrand G et al (1997) Comparative effects of adenosine-5’-triphosphate and related analogues on insulin secretion from the rat pancreas. Fundam Clin Pharmacol 11(6):537–545
Bertrand G, Gross R, Chapal J et al (1989) Difference in the potentiating effect of adenosine triphosphate and alpha, beta-methylene ATP on the biphasic insulin response to glucose. Br J Pharmacol 98(3):998–1004
Loubatieres-Mariani MM, Chapal J, Lignon F et al (1979) Structural specificity of nucleotides for insulin secretory action from the isolated perfused rat pancreas. Eur J Pharmacol 59(3–4):277–286
Petit P, Manteghetti M, Puech R et al (1987) ATP and phosphate-modified adenine nucleotide analogues. Effects on insulin secretion and calcium uptake. Biochem Pharmacol 36(3):377–380
Xie L, Zhang M, Zhou W et al (2006) Extracellular ATP stimulates exocytosis via localized Ca2+ release from acidic stores in rat pancreatic β cells. Traffic 7(4):429–439. doi:10.1111/j.1600-0854.2006.00401.x
Gylfe E, Hellman B (1987) External ATP mimics carbachol in initiating calcium mobilization from pancreatic beta-cells conditioned by previous exposure to glucose. Br J Pharmacol 92(2):281–289
Chevassus H, Roig A, Belloc C et al (2002) P2Y receptor activation enhances insulin release from pancreatic beta-cells by triggering the cyclic AMP/protein kinase A pathway. Naunyn Schmiedeberg's Arch Pharmacol 366(5):464–469. doi:10.1007/s00210-002-0620-4
Amisten S, Meidute-Abaraviciene S, Tan C et al (2010) ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice. Diabetologia 53(9):1927–1934. doi:10.1007/s00125-010-1807-8
Parandeh F, Abaraviciene SM, Amisten S et al (2008) Uridine diphosphate (UDP) stimulates insulin secretion by activation of P2Y6 receptors. Biochem Biophys Res Commun 370(3):499–503. doi:10.1016/j.bbrc.2008.03.119
Fernandez-Alvarez J, Hillaire-Buys D, Loubatières-Mariani MM et al (2001) P2 receptor agonists stimulate insulin release from human pancreatic islets. Pancreas 22(1):69–71
Jacques-Silva MC, Correa-Medina M, Cabrera O et al (2010) ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell. Proc Natl Acad Sci U S A 107(14):6465–6470. doi:10.1073/pnas.0908935107
Khan S, Yan-Do R, Duong E et al (2014) Autocrine activation of P2Y1 receptors couples Ca2+ influx to Ca2+ release in human pancreatic beta cells. Diabetologia 57(12):2535–2545. doi:10.1007/s00125-014-3368-8
Silvestre RA, Rodríguez-Gallardo J, Egido EM et al (1999) Stimulatory effect of exogenous diadenosine tetraphosphate on insulin and glucagon secretion in the perfused rat pancreas. Br J Pharmacol 128(3):795–801. doi:10.1038/sj.bjp.0702837
Bertrand G, Gross R, Ribes G et al (1990) P2 purinoceptor agonists stimulate somatostatin secretion from dog pancreas. Eur J Pharmacol 182(2):369–373
Hillaire-Buys D, Gross R, Parés-Herbuté N et al (1994) In vivo and in vitro effects of adenosine-5’-O-(2-thiodiphosphate) on pancreatic hormones in dogs. Pancreas 9(5):646–651
Salehi A, Qader SS, Grapengiesser E et al (2007) Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon. Regul Pept 144(1–3):43–49. doi:10.1016/j.regpep.2007.06.003
Lee YH, Lee SJ, Seo MH et al (2001) ATP-induced histamine release is in part related to phospholipase A2-mediated arachidonic acid metabolism in rat peritoneal mast cells. Arch Pharm Res 24(6):552–556
Bennett JP, Cockcroft S, Gomperts BD (1981) Rat mast cells permeabilized with ATP secrete histamine in response to calcium ions buffered in the micromolar range. J Physiol 317:335–345
Cockcroft S, Gomperts BD (1979) Activation and inhibition of calcium-dependent histamine secretion by ATP ions applied to rat mast cells. J Physiol 296:229–243
Jaffar ZH, Pearce FL (1990) Histamine secretion from mast cells stimulated with ATP. Agents Actions 30(1–2):64–66
Schulman ES, Glaum MC, Post T et al (1999) ATP modulates anti-IgE-induced release of histamine from human lung mast cells. Am J Respir Cell Mol Biol 20(3):530–537. doi:10.1165/ajrcmb.20.3.3387
Di Virgilio F (2007) Liaisons dangereuses: P2X7 and the inflammasome. Trends Pharmacol Sci 28(9):465–472. doi:10.1016/j.tips.2007.07.002
Ferrari D, Pizzirani C, Adinolfi E et al (2006) The P2X7 receptor: a key player in IL-1 processing and release. J Immunol 176(7):3877–3883
Piccini A, Carta S, Tassi S et al (2008) ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way. Proc Natl Acad Sci U S A 105(23):8067–8072. doi:10.1073/pnas.0709684105
Gicquel T, Robert S, Loyer P et al (2015) IL-1β production is dependent of the activation of purinergic receptors and NLRP3 pathway in human macrophages. FASEB J 29(10):4162–4173. doi:10.1096/fj.14-267393
Gicquel T, Victoni T, Fautrel A et al (2014) Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages. Clin Exp Pharmacol Physiol 41(4):279–286. doi:10.1111/1440-1681.12214
Kawano A, Tsukimoto M, Mori D et al (2012) Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages. Biochem Biophys Res Commun 420(1):102–107. doi:10.1016/j.bbrc.2012.02.122
Toki Y, Takenouchi T, Harada H et al (2015) Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death. Biochem Biophys Res Commun 458(4):771–776. doi:10.1016/j.bbrc.2015.02.011
Kojima S, Negishi Y, Tsukimoto M et al (2014) Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle. Toxicology 321:13–20. doi:10.1016/j.tox.2014.03.008
Pelegrin P, Barroso-Gutierrez C, Surprenant A (2008) P2X7 receptor differentially couples to distinct release pathways for IL-1 in mouse macrophage. J Immunol 180(11):7147–7157. doi:10.4049/jimmunol.180.11.7147
Asgari E, Le Friec G, Yamamoto H et al (2013) C3a modulates IL-1 secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. Blood 122(20):3473–3481. doi:10.1182/blood-2013-05-502229
Netea MG, Nold-Petry CA, Nold MF et al (2009) Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 113(10):2324–2335. doi:10.1182/blood-2008-03-146720
Pizzirani C, Ferrari D, Chiozzi P et al (2007) Stimulation of P2 receptors causes release of IL-1beta-loaded microvesicles from human dendritic cells. Blood 109(9):3856–3864. doi:10.1182/blood-2005-06-031377
Englezou PC, Rothwell SW, Ainscough JS et al (2015) P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages. Cytokine 74(2):293–304. doi:10.1016/j.cyto.2015.05.013
Sanz JM, Di Virgilio F (2000) Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells. J Immunol 164(9):4893–4898
Ferrari D, Chiozzi P, Falzoni S et al (1997) Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin. J Exp Med 185(3):579–582
Clark AK, Staniland AA, Marchand F et al (2010) P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide. J Neurosci 30(2):573–582. doi:10.1523/JNEUROSCI.3295-09.2010
Bianco F, Pravettoni E, Colombo A et al (2005) Astrocyte-derived ATP induces vesicle shedding and IL-1 release from microglia. J Immunol 174(11):7268–7277. doi:10.4049/jimmunol.174.11.7268
Kanjanamekanant K, Luckprom P, Pavasant P (2013) Mechanical stress-induced interleukin-1beta expression through adenosine triphosphate/P2X7 receptor activation in human periodontal ligament cells. J Periodontal Res 48(2):169–176. doi:10.1111/j.1600-0765.2012.01517.x
Carta S, Penco F, Lavieri R et al (2015) Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance. Proc Natl Acad Sci U S A 112(9):2835–2840. doi:10.1073/pnas.1424741112
Wilson HL, Varcoe RW, Stokes L et al (2007) P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells. Br J Pharmacol 151(1):115–127. doi:10.1038/sj.bjp.0707213
Wilson HL, Francis SE, Dower SK et al (2004) Secretion of intracellular IL-1 receptor antagonist (Type 1) is dependent on P2X7 receptor activation. J Immunol 173(2):1202–1208. doi:10.4049/jimmunol.173.2.1202
Glas R, Sauter NS, Schulthess FT et al (2009) Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival. Diabetologia 52(8):1579–1588. doi:10.1007/s00125-009-1349-0
Kouzaki H, Iijima K, Kobayashi T et al (2011) The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol 186(7):4375–4387. doi:10.4049/jimmunol.1003020
Martin U, Scholler J, Gurgel J et al (2009) Externalization of the leaderless cytokine IL-1 F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages. J Immunol 183(6):4021–4030. doi:10.4049/jimmunol.0803301
Gavala ML, Liu Y, Lenertz LY et al (2013) Nucleotide receptor P2RX7 stimulation enhances LPS-induced interferon-β production in murine macrophages. J Leukoc Biol 94(4):759–768. doi:10.1189/jlb.0712351
Schilling E, Hauschildt S (2012) Extracellular ATP induces P2X7-dependent nicotinamide phosphoribosyltransferase release in LPS-activated human monocytes. Innate Immun 18(5):738–744. doi:10.1177/1753425912439614
Erlinge D (1998) Extracellular ATP: a growth factor for vascular smooth muscle cells. Gen Pharmacol 31(1):1–8
Burnstock G (2013) Purinergic signalling: pathophysiology and therapeutic potential. Keio J Med 62(3):63–73
Neary JT, Zimmermann H (2009) Trophic functions of nucleotides in the central nervous system. Trends Neurosci 32(4):189–198. doi:10.1016/j.tins.2009.01.002
Grimm I, Ullsperger SN, Zimmermann H (2010) Nucleotides and epidermal growth factor induce parallel cytoskeletal rearrangements and migration in cultured adult murine neural stem cells. Acta Physiol (Oxf) 199(2):181–189. doi:10.1111/j.1748-1716.2010.02092.x
Grimm I, Messemer N, Stanke M et al (2009) Coordinate pathways for nucleotide and EGF signaling in cultured adult neural progenitor cells. J Cell Sci 122(14):2524–2533. doi:10.1242/jcs.044891
Mishra SK (2006) Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation. Development 133(4):675–684. doi:10.1242/dev.02233
Arthur DB, Georgi S, Akassoglou K et al (2006) Inhibition of apoptosis by P2Y2 receptor activation: novel pathways for neuronal survival. J Neurosci 26(14):3798–3804. doi:10.1523/JNEUROSCI.5338-05.2006
Henquin JC (2000) Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 49(11):1751–1760
Petit P, Bertrand G, Schmeer W et al (1989) Effects of extracellular adenine nucleotides on the electrical, ionic and secretory events in mouse pancreatic beta-cells. Br J Pharmacol 98(3):875–882
Léon C, Freund M, Latchoumanin O et al (2005) The P2Y1 receptor is involved in the maintenance of glucose homeostasis and in insulin secretion in mice. Purinergic Signal 1(2):145–151. doi:10.1007/s11302-005-6209-x
Tudurí E, Filiputti E, Carneiro EM et al (2008) Inhibition of Ca2+ signaling and glucagon secretion in mouse pancreatic alpha-cells by extracellular ATP and purinergic receptors. Am J Physiol Endocrinol Metab 294(5):E952–E960. doi:10.1152/ajpendo.00641.2007
Abbracchio MP, Burnstock G, Boeynaems J et al (2006) International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev 58(3):281–341. doi:10.1124/pr.58.3.3
Castillo CJ, Moro MA, Del Valle M et al (1992) Diadenosine tetraphosphate is co-released with ATP and catecholamines from bovine adrenal medulla. J Neurochem 59(2):723–732
Dinarello CA (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27(1):519–550. doi:10.1146/annurev.immunol.021908.132612
Di Virgilio F (2013) The therapeutic potential of modifying inflammasomes and NOD-like receptors. Pharmacol Rev 65(3):872–905. doi:10.1124/pr.112.006171
Schroder K, Tschopp J (2010) The inflammasomes. Cell 140(6):821–832. doi:10.1016/j.cell.2010.01.040
Church LD, Cook GP, McDermott MF (2008) Primer: inflammasomes and interleukin 1beta in inflammatory disorders. Nat Clin Pract Rheumatol 4(1):34–42. doi:10.1038/ncprheum0681
Gudipaty L, Munetz J, Verhoef PA et al (2003) Essential role for Ca2+ in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells. Am J Physiol Cell Physiol 285(2):C286–C299. doi:10.1152/ajpcell.00070.2003
Di Virgilio F, Chiozzi P, Ferrari D et al (2001) Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 97(3):587–600
Choi AJS, Ryter SW (2014) Inflammasomes: molecular regulation and implications for metabolic and cognitive diseases. Mol Cell 37(6):441–448. doi:10.14348/molcells.2014.0104
Ferrari D, Chiozzi P, Falzoni S et al (1997) Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J Immunol 159(3):1451–1458
Surprenant A, Rassendren F, Kawashima E et al (1996) The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science 272(5262):735–738
Di Virgilio F (1995) The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death. Immunol Today 16(11):524–528. doi:10.1016/0167-5699(95)80045-X
Franceschini A, Capece M, Chiozzi P et al (2015) The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein. FASEB J 29(6):2450–2461. doi:10.1096/fj.14-268714
Arend WP (2002) The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev 13(4–5):323–340. doi:10.1016/S1359-6101(02)00020-5
Dinarello CA (2007) Historical insights into cytokines. Eur J Immunol 37(Suppl 1):S34–S45. doi:10.1002/eji.200737772
Novick D, Kim S, Kaplanski G et al (2013) Interleukin-18, more than a Th1 cytokine. Semin Immunol 25(6):439–448. doi:10.1016/j.smim.2013.10.014
Grahnert A, Grahnert A, Klein C et al (2011) Review: NAD+: a modulator of immune functions. Innate Immun 17(2):212–233. doi:10.1177/1753425910361989
Osipchuk Y, Cahalan M (1992) Cell-to-cell spread of calcium signals mediated by ATP receptors in mast cells. Nature 359(6392):241–244. doi:10.1038/359241a0
Yang S, Cheek DJ, Westfall DP et al (1994) Purinergic axis in cardiac blood vessels. Agonist-mediated release of ATP from cardiac endothelial cells. Circ Res 74(3):401–407
Bodin P, Burnstock G (1996) ATP-stimulated release of ATP by human endothelial cells. J Cardiovasc Pharmacol 27(6):872–875
Newman EA (2001) Propagation of intercellular calcium waves in retinal astrocytes and Müller cells. J Neurosci 21(7):2215–2223
Pearson RA, Dale N, Llaudet E et al (2005) ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation. Neuron 46(5):731–744. doi:10.1016/j.neuron.2005.04.024
Frayling C, Britton R, Dale N (2011) ATP-mediated glucosensing by hypothalamic tanycytes. J Physiol 589(Pt 9):2275–2286. doi:10.1113/jphysiol.2010.202051
Weissman TA, Riquelme PA, Ivic L et al (2004) Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex. Neuron 43(5):647–661. doi:10.1016/j.neuron.2004.08.015
Dou Y, Wu H, Li H et al (2012) Microglial migration mediated by ATP-induced ATP release from lysosomes. Cell Res 22(6):1022–1033. doi:10.1038/cr.2012.10
Gylfe E, Grapengiesser E, Dansk H et al (2012) The neurotransmitter ATP triggers Ca2+ responses promoting coordination of pancreatic islet oscillations. Pancreas 41(2):258–263. doi:10.1097/MPA.0b013e3182240586
Hellman B, Dansk H, Grapengiesser E (2004) Pancreatic beta-cells communicate via intermittent release of ATP. Am J Physiol Endocrinol Metab 286(5):E759–E765. doi:10.1152/ajpendo.00452.2003
Kawano A, Kadomatsu R, Ono M et al (2015) Autocrine regulation of UVA-induced IL-6 production via release of ATP and activation of P2Y receptors. PLoS ONE 10(6), e0127919. doi:10.1371/journal.pone.0127919
Pannasch U, Rouach N (2013) Emerging role for astroglial networks in information processing: from synapse to behavior. Trends Neurosci 36(7):405–417. doi:10.1016/j.tins.2013.04.004
Arcuino G, Lin JH, Takano T et al (2002) Intercellular calcium signaling mediated by point-source burst release of ATP. Proc Natl Acad Sci U S A 99(15):9840–9845. doi:10.1073/pnas.152588599
Agulhon C, Sun M, Murphy T et al (2012) Calcium signaling and gliotransmission in normal vs. reactive astrocytes. Front Pharmacol 3:139. doi:10.3389/fphar.2012.00139
Rossi DJ, Brady JD, Mohr C (2007) Astrocyte metabolism and signaling during brain ischemia. Nat Neurosci 10(11):1377–1386. doi:10.1038/nn2004
Melani A, Corti F, Stephan H et al (2012) Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum. Exp Neurol 233(1):193–204. doi:10.1016/j.expneurol.2011.09.036
Beigi R, Kobatake E, Aizawa M et al (1999) Detection of local ATP release from activated platelets using cell surface-attached firefly luciferase. Am J Physiol 276(1 Pt 1):C267–C278
Di Virgilio F, Vuerich M (2015) Purinergic signaling in the immune system. Auton Neurosci 191:117–123. doi:10.1016/j.autneu.2015.04.011
Riteau N, Baron L, Villeret B et al (2012) ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation. Cell Death Dis 3, e403. doi:10.1038/cddis.2012.144
Rossi L, Salvestrini V, Ferrari D et al (2012) The sixth sense: hematopoietic stem cells detect danger through purinergic signaling. Blood 120(12):2365–2375. doi:10.1182/blood-2012-04-422378
Alves LA, Bezerra RJS, Faria RX et al (2013) Physiological roles and potential therapeutic applications of the P2X7 receptor in inflammation and pain. Molecules 18(9):10953–10972. doi:10.3390/molecules180910953
Arulkumaran N, Unwin RJ, Tam FW (2011) A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases. Expert Opin Investig Drugs 20(7):897–915. doi:10.1517/13543784.2011.578068
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Zimmermann, H. Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release. Purinergic Signalling 12, 25–57 (2016). https://doi.org/10.1007/s11302-015-9483-2
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DOI: https://doi.org/10.1007/s11302-015-9483-2