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Diabetes and Its Effect on Bone and Fracture Healing

  • Bone and Diabetes (AV Schwartz and P Vestergaard, Section Editors)
  • Published:
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Abstract

Diabetes mellitus is a metabolic disorder that increases fracture risk, interferes with bone formation, and impairs fracture healing. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) both increase fracture risk and have several common features that affect the bone including hyperglycemia and increased advanced glycation end product (AGE) formation, reactive oxygen species (ROS) generation, and inflammation. These factors affect both osteoblasts and osteoclasts leading to increased osteoclasts and reduced numbers of osteoblasts and bone formation. In addition to fracture healing, T1DM and T2DM impair bone formation under conditions of perturbation such as bacteria-induced periodontal bone loss by increasing osteoblast apoptosis and reducing expression of factors that stimulate osteoblasts such as BMPs and growth factors.

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Authors and Affiliations

  1. Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Hongli Jiao, E. Xiao & Dana T. Graves

  2. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, 100081, China

    E. Xiao & Dana T. Graves

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  1. Hongli Jiao
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  2. E. Xiao
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  3. Dana T. Graves
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Correspondence to Dana T. Graves.

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This article is part of the Topical Collection on Bone and Diabetes

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Jiao, H., Xiao, E. & Graves, D.T. Diabetes and Its Effect on Bone and Fracture Healing. Curr Osteoporos Rep 13, 327–335 (2015). https://doi.org/10.1007/s11914-015-0286-8

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  • DOI: https://doi.org/10.1007/s11914-015-0286-8

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