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Role of Marrow Adipocytes in Regulation of Energy Metabolism and Bone Homeostasis

  • Bone Marrow and Adipose Tissue (G Duque and B Lecka-Czernik, Section Editors)
  • Published:
Current Osteoporosis Reports Aims and scope Submit manuscript

Abstract

Purpose of review

The goal of this review is to gain a better understanding of marrow adipocyte development, its regulation of energy, and its characterization responsible for bone homeostasis.

Recent findings

Despite major advances in uncovering the complex association of bone-fat in the marrow, the underlying basic biological process of adipose tissue development, as well as its interaction with bone homeostasis in pathophysiological conditions, is still not well understood.

Summary

This review identifies many pro- and anti-osteogenic factors secreted by adipocytes to play a role in the manipulating the fate of mesenchymal stem cells as well as the osteoblastic activity during bone remodeling. It also addresses the function of adipose tissue capable of negative regulation of the hematopoietic microenvironment to influence the bone quantity and the nature of bone homeostasis.

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Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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  1. Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road Grafton, Auckland, New Zealand

    Jillian Cornish, Tao Wang & Jian-ming Lin

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  1. Jillian Cornish
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Correspondence to Jillian Cornish.

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Jillian Cornish, Tao Wang, and Jian-Ming Lin declare no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Bone Marrow and Adipose Tissue

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Cornish, J., Wang, T. & Lin, Jm. Role of Marrow Adipocytes in Regulation of Energy Metabolism and Bone Homeostasis. Curr Osteoporos Rep 16, 116–122 (2018). https://doi.org/10.1007/s11914-018-0425-0

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