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The Role of ANK in Calcium Pyrophosphate Deposition Disease

  • Crystal Arthritis (MH Pillinger and SK Samuels, Section Editors)
  • Published:
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Abstract

The protein product of the progressive ankylosis gene, known as ANK, is a 492-amino acid multi-pass transmembrane protein. This protein is critical for the regulation of pyrophosphate, and gain of function ANK mutations is associated with calcium pyrophosphate deposition disease. Much about the structure, function, and regulation of ANK remain unstudied. This review of the current literature examines recent contributions to our understanding of ANK. We focus on new work on the function, binding partners, and regulators of ANK. A more complete understanding of this important protein may help to identify future therapeutic targets for the treatment of calcium pyrophosphate deposition disease.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. The Division of Rheumatology, Department of Medicine, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, WI, 53295-1000, USA

    Elizabeth Mitton-Fitzgerald, Claudia M. Gohr, Brittany Bettendorf & Ann K. Rosenthal

Authors
  1. Elizabeth Mitton-Fitzgerald
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  2. Claudia M. Gohr
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  3. Brittany Bettendorf
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  4. Ann K. Rosenthal
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Corresponding author

Correspondence to Claudia M. Gohr.

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EMF, CMG, BB, and AKR declare that they have no conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Mitton-Fitzgerald, E., Gohr, C.M., Bettendorf, B. et al. The Role of ANK in Calcium Pyrophosphate Deposition Disease. Curr Rheumatol Rep 18, 25 (2016). https://doi.org/10.1007/s11926-016-0574-z

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  • DOI: https://doi.org/10.1007/s11926-016-0574-z

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