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Bcl-3, a multifaceted modulator of NF-κB-mediated gene transcription

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Abstract

The transcription factor, NF-κB (nuclear factor-κB) and associated regulatory factors make up a multi-component signaling pathway that regulates a wide range of biological processes, including cell survival, proliferation, differentiation, stress response, and death, as well as immunity and inflammation. Aberrant NF-κB pathway activity is known to be associated with a host of diseases, including immune deficiencies, inflammatory disorders, and cancer. Recent advances in our understanding of the inner workings of the NF-κB pathway have led to the development of new therapeutic strategies for the treatment of these diseases. In this review, we focus on the regulation of the NF-κB pathway by Bcl-3 (B cell leukemia-3), a nuclear member of the IκB (inhibitor of NF-κB) family. Both the regulation and the function of Bcl-3 will be discussed.

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  1. Department of Pathology and Laboratory of Medicine, School of Medicine, University of Pennsylvania, 713 Stellar Chance Labs. 422 Curie Blvd., Philadelphia, PA, 19104, USA

    Scott Palmer & Youhai H. Chen

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Correspondence to Youhai H. Chen.

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Palmer, S., Chen, Y.H. Bcl-3, a multifaceted modulator of NF-κB-mediated gene transcription. Immunol Res 42, 210–218 (2008). https://doi.org/10.1007/s12026-008-8075-4

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