Abstract
Empathy deficit is a core feature of schizophrenia which may lead to social dysfunction. The present study was carried out to investigate functional and structural abnormalities associated with empathy in patients with schizophrenia using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM). A sample of 14 schizophrenia patients and 14 healthy control subjects matched for age, sex and education were examined with structural high-resolution T1-weighted MRI; fMRI images were obtained during empathy task in the same session. The analysis was carried out using SPM8 software. On behavioural assessment, schizophrenic patients (83.00±29.04) showed less scores for sadness compared to healthy controls (128.70±22.26) (p<0.001). fMRI results also showed reduced clusters of activation in the bilateral fusiform gyrus, left lingual gyrus, left middle and inferior occipital gyrus in schizophrenic subjects as compared to controls during empathy task. In the same brain areas, VBM results also showed reduced grey and white matter volumes. The present study provides an evidence for an association between structural alterations and disturbed functional brain activation during empathy task in persons affected with schizophrenia. These findings suggest a biological basis for social cognition deficits in schizophrenics.
Similar content being viewed by others
References
Achim AM, Ouellet R, Roy MA and Jackson PL 2011 Assessment of empathy in first-episode psychosis and meta-analytic comparison with previous studies in schizophrenia. Psychiatry Res. 190 3–8
Adolphs R 2002 Neural systems for recognizing emotion. Curr. Opin. Neurobiol. 212 169–177
Ananth H, Popescu I, Critchley HD, Good CD, Frackowiak RS and Dolan RJ 2002 Cortical and subcortical gray matter abnormalities in schizophrenia determined through structural magnetic resonance imaging with optimized volumetric voxelbased morphometry. Am. J. Psychiatry 159 1497–1505
Ashburner J 2010 VBM Tutorial. http://www.fil.ion.ucl.ac.uk/~john/misc/VBMclass10.Pdf
Ashburner J and Friston KJ 2000 Voxel-based morphometry-the methods. Neuroimage 11 805–821
Benedetti F, Bernasconi A, Bosia M, Cavallaro R, Dallaspezia S, Falini A, Poletti S, Radaelli D, et al. 2009 Functional and structural brain correlates of theory of mind and empathy deficits in schizophrenia. Schizophr. Res. 114 154–160
Bora E, Gökçen S and Veznedaroglu B 2008 Empathic abilities in people with schizophrenia. Psychiatry Res. 160 23–29
Davis M, Luce C and Kraus S 1994 The heritability of characteristics associated with dispositional empathy. J. Pers. 62 369–391
Davis M 1983 Measuring individual differences in empathy: Evidence for a multidimensional approach. J. Pers. Soc. Psychol. 44 113–126
Decety J and Moriguchi Y 2007. The empathic brain and its dysfunction in psychiatric populations: implications for intervention across different clinical conditions. BioPsychoSocial Med. 1–22
Derntl B, Finkelmeyer A, Toygar TK, Hulsmann A, Schneider F, Falkenberg DI and Habel U 2009 Generalized deficit in all core components of empathy in schizophrenia. Schizophr. Res. 108 197–206
Derntl B, Finkelmeyer A, Voss B, Eickhoff SB, Kellermann T, Schneider F and Habel U 2012 Neural correlates of the core facets of empathy in schizophrenia. Schizophr. Res. 136 70–81
Deshpande SN, Mathur MN, Das SK, Bhatia T, Sharma S and Nimgaonkar VL 1998 A Hindi version of the diagnostic interview for genetic studies. Schizophr. Bull. 24 489–493
Eickhoff SB, Stephan KE and Mohlberg H 2005 A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data. NeuroImage 25 1325–1335
Eisenberg N and Miller PA 1987 The relation of empathy to prosocial and related behaviors. Psychol. Bull. 101 91–119
Friston KJ and Worksley KJ 2005 Analysis of fMRI time series revisited again. Neuroimage 2 173–181
Haker H, Schimansky J, Jann S and Rossler W 2012 Self-reported empathic abilities in schizophrenia: A longitudinal perspective. Psychiatry Res. 200 1028–1031
Harvey PD, Patterson TL, Potter LS, Zhong K, Brecher M 2006 Improvement in social competence with short-term atypical antipsychotic treatment: a randomized, double-blind comparison of quetiapine versus risperidone for social competence, social cognition, and neuropsychological functioning. Am. J. Psychiatry 163 1918–1925
Harvey PO, Zaki J, Lee J, Ochsner K and Green MF 2013 Neural Substrates of Empathic Accuracy in People with Schizophrenia. Schizophr. Bull. 39 617–628
Henry JD, Bailey PE and Rendell PG 2008 Empathy, social functioning and schizotypy. Psychiatry Res. 160 15–22
Hulshoff Pol HE, Schnack HG, Bertens MGBC, van Haren NEM, van der Tweel I, Staal WG, Baaré WFC and Kahn RS 2002 Volume changes in gray matter in patients with schizophrenia. Am. J. Psychiatry 159 244–250
Lee J, Zaki J, Harvey PO, Ochsner K and Green MF 2011 Schizophrenia patients are impaired in empathic accuracy. Psychol. Med. 41 2297–2304
Lee SJ, Kang DH, Kim C, Gu BM, Park J, Choi C, Shin NY, Lee J-M, et al. 2010 Multi-level comparison of empathy in schizophrenia: an fMRI study of a cartoon task. Psychiatry Res. 181 121–129
Modi S, Khushu S, Bhattacharya M, Raj SB, Varshney A, Mandal MK 2008. Neurocognitive processing of socially relevant negative emotions – an fMRI study. In: European Congress of Radiology, Vienna, Austria: ECR.
Montag C, Heinz A, Kunz D and Gallinat J 2007 Self-reported empathic abilities in schizophrenia. Schizophr. Res. 92 85–89
Nurnberger JI Jr, Blehar MC and Kaufmann CA 1994 Diagnostic interview for genetic studies. Rationale, unique features and training. NIHM Genetics Initiative. Arch. Gen. Psychiatry 51 849–859
Ochsner KN, Knierim K, Ludlow DH, Hanelin J, Ramachandran T, Glover G and Mackey SC 2004 Reflecting upon feelings: an fMRI study of neural systems supporting the attribution of emotion to self and other. J. Cogn. Neurosci. 16 1746–1772
Shapleske J, Rossell SL, Chitnis XA, Suckling J, Simmons A, Bullmore ET, Woodruff PW and David AS 2002 A computational morphometric MRI study of schizophrenia: effects of hallucinations. Cereb. Cortex 12 1331–1341
Sigmundsson T, Suckling J, Maier M, Williams S, Bullmore E, Greenwood K, Fukuda R, Ron M, et al. 2001 Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. Am. J. Psychiatry 158 234–243
Smith MJ, Horan WP, Karpouzian TM, Abram SV, Cobia DJ and Csernansky JG 2012 Self-reported empathy deficits are uniquely associated with poor functioning in schizophrenia. Schizophr. Res. 137 196–202
Völlm BA, Taylor AN, Richardson P, Corcoran R, Stirling J, McKie S, Deakin JF and Elliott R 2006 Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task. Neuroimage 29 90–98
Acknowledgements
This work was supported by DRDO R&D Project No. INM-311(4.1), and funded in part by grant from the Fogarty International Centre, NIH The Impact of Yoga Supplementation on Cognitive Function Among Indian Outpatients Grant #1R01TW008289 to TB. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or other funding agencies.
Author information
Authors and Affiliations
Corresponding author
Additional information
Corresponding editor: Anant Bahadur Patel
[Singh S, Modi S, Goyal S, Kaur P, Singh N, Bhatia T, Deshpande SN and Khushu S 2015 Functional and structural abnormalities associated with empathy in patients with schizophrenia: An fMRI and VBM study. J. Biosci. 40 1–10] DOI 10.1007/s12038-015-9509-5
Rights and permissions
About this article
Cite this article
Singh, S., Modi, S., Goyal, S. et al. Functional and structural abnormalities associated with empathy in patients with schizophrenia: An fMRI and VBM study. J Biosci 40, 355–364 (2015). https://doi.org/10.1007/s12038-015-9509-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12038-015-9509-5