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Modeling Human Craniofacial Disorders in Xenopus

  • Xenopus and Zebrafish Models for Pathobiology (W Goessling and A Zorn, Section Editors)
  • Published:
Current Pathobiology Reports

Abstract

Purpose of Review

Craniofacial disorders are among the most common human birth defects and present an enormous health care and social burden. The development of animal models has been instrumental to investigate fundamental questions in craniofacial biology, and this knowledge is critical to understand the etiology and pathogenesis of these disorders.

Recent Findings

The vast majority of craniofacial disorders arise from abnormal development of the neural crest, a multipotent and migratory cell population. Therefore, defining the pathogenesis of these conditions starts with a deep understanding of the mechanisms that preside over neural crest formation and its role in craniofacial development.

Summary

This review discusses several studies using Xenopus embryos to model human craniofacial conditions and emphasizes the strength of this system to inform important biological processes as they relate to human craniofacial development and disease.

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Acknowledgements

Work in the Saint-Jeannet Lab is supported by the National Institutes of Health (NIH), grant numbers R01DE25806 and R01DE25468.

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  1. Department of Basic Science & Craniofacial Biology, College of Dentistry, New York University, 345 East 24th Street, New York, NY, 10010, USA

    Aditi Dubey & Jean-Pierre Saint-Jeannet

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  1. Aditi Dubey
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  2. Jean-Pierre Saint-Jeannet
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Correspondence to Jean-Pierre Saint-Jeannet.

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A.D. and J.-P.S.-J. declare that they have no competing interests.

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This article is part of the Topical Collection on Xenopus and Zebrafish Models for Pathobiology

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Dubey, A., Saint-Jeannet, JP. Modeling Human Craniofacial Disorders in Xenopus . Curr Pathobiol Rep 5, 79–92 (2017). https://doi.org/10.1007/s40139-017-0128-8

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