Mode of action of the herbicide, 3-amino-1,2,4-triazole(amitrole): Inhibition of an enzyme of histidine biosynthesis

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Abstract

The herbicide 3-amino-1,2,4-triazole (amitrole) is shown to inhibit imidazoleglycerol phosphate dehydratase, an enzyme of histidine biosynthesis, in Salmonella typhimurium. Amitrole also appears to inhibit purine synthesis. Inhibition of the bacteria by amitrole is potentiated by triazolealanine, a histidine analogue, that prevents derepression of the histidine biosynthetic enzymes. The mode of action of the herbicide is discussed in view of these findings.

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