Effects of adenosine on liver cell damage induced by carbon tetrachloride
References (43)
- et al.
Archs Biochem. Biophys.
(1978) - et al.
Biochem. Pharmac.
(1980) - et al.
Biochem. Pharmac.
(1979) - et al.
J. Lipid. Res.
(1961) J. Lipid Res.
(1965)- et al.
J. biol. Chem.
(1960) - et al.
- et al.
J. biol. Chem.
(1957) - et al.
Biochem. Pharmac.
(1975) - et al.
J. Lipid Res.
(1962)
J. biol. Chem.
Archs Biochem. Biophys.
Biochem. Pharmac.
Biochem. biophys. Res. Commun.
J. biol. Chem.
J. biol. Chem.
Biochem. Pharmac.
Archs. environ. Hlth
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Involvement of cell oxidant status and redox state in the increased non-enzymatic ethanol oxidation by the regenerating rat liver
2019, Biochemical PharmacologyCitation Excerpt :In the same acid extracts, neutralized with 4 mol • L−1 K2CO3, the redox-pair metabolites: lactate, pyruvate, α-glycerophosphate, dihydroxyacetone phosphate, β-hydroxybutyrate, and acetoacetate, were enzymatically determined, as described before [29,30]. The amount of aldehydic products generated by lipid peroxidation was quantified in the cytosolic fraction through the technique using the thiobarbituric acid reaction (TBARS), as previously modified [31]. Cytoplasmic and mitochondrial NAD/NADH ratios were calculated as follows: NAD/NADH = [oxidized substrate]/[reduced substrate] × 1/Keq, taking into account equilibrium constants for lactate, α-glycerophosphate, and β-hydroxybutyrate dehydrogenases [32].
An Adenosine Derivative Compound as a Hepatoprotective Agent
2017, Liver Pathophysiology: Therapies and AntioxidantsNeuroprotective effect of thalidomide on MPTP-induced toxicity
2015, NeuroToxicologyCitation Excerpt :MAO activity was expressed as μmol of 4-HOQ formed/1 h incubation per g of tissue wet weight. The amount of aldehydic products generated by lipoperoxidation was determined by the thiobarbituric acid reactive substances (TBARS) (Buege and Aust, 1978) in 10 brain ST and SN per group, modified as previously reported (Hernandez-Munoz et al., 1984). Briefly, homogenate preparation for the MAO-B determination, was taken 1 mg of protein per sample, was diluted in Tris–HCl (150 mM, pH 7.4) buffer.
α-Tocopherol administration blocks adaptive changes in cell NADH/NAD<sup>+</sup> redox state and mitochondrial function leading to inhibition of gastric mucosa cell proliferation in rats
2013, Free Radical Biology and MedicineCitation Excerpt :In isolated mitochondria from our experimental groups, the following enzymatic activities were measured: cytochrome c oxidase (Cox; EC 1.9.3.1) was determined by the method described by Rafael [22] and succinate dehydrogenase (SDH; EC 1.2.1.16) according to the technique of King [23]. The activity of two mitochondrial matrix enzymes, malate dehydrogenase (MDH; EC 1.1.1.37) and isocitrate dehydrogenase (IDH; EC 1.1.1.42), was assessed by methods reported elsewhere [24,25]. Mitochondrial levels of ROS were estimated through the method described by Viarengo et al. [26], using the fluorescence signal generated by ROS reacting with 2′,7′-dichlorodihydrofluorescein diacetate (Molecular Probes).
Prevention of in vitro hepatic stellate cells activation by the adenosine derivative compound IFC305
2010, Biochemical PharmacologyCitation Excerpt :We have determined that adenosine reverses experimental cirrhosis by enhancing liver collagenolytic activity, stimulating hepatocyte proliferative capacities, as well as accelerating normalization of parameters indicative of liver function and reducing levels of oxidative stress. Adenosine's beneficial effects have been associated with a cell redox state modulation, maintenance of liver energy availability, and an adequate mitochondrial function of hepatic cells [8–13]. Recently, we synthesized the aspartate salt of adenosine IFC305, which has a longer half-life in the liver and its beneficial effects on CCl4-induced cirrhosis in rats are achieved with a lower dose [14].
Food restricted schedules promote differential lipoperoxidative activity in rat hepatic subcellular fractions
2007, Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology